The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

In Situ Monitoring of Bacteria under Antimicrobial Stress Using 31P Solid-State NMR

(2019) Sarah Overall et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function

(2019) Elizabeth Calzada et al.   Nature Communications

Assembly of the complexes of oxidative phosphorylation triggers the remodeling of cardiolipin

(2019) Yang Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the links between lipid geometry and mitochondrial fission: Emerging concepts

(2019) Ashutosh Agrawal et al.   MITOCHONDRION

A critical appraisal of the tafazzin knockdown mouse model of Barth syndrome: what have we learned about pathogenesis and potential treatments?

(2019) Mindong Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular Dynamics Analysis of Cardiolipin and Monolysocardiolipin on Bilayer Properties

(2018) Kevin J. Boyd et al.   BIOPHYSICAL JOURNAL

Cardiolipin-targeted peptides rejuvenate mitochondrial function, remodel mitochondria, and promote tissue regeneration during aging

(2018) Hazel H. Szeto et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Stealth Peptides Target Cellular Powerhouses to Fight Rare and Common Age-Related Diseases

(2018) Hazel H. Szeto   PROTEIN AND PEPTIDE LETTERS

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer’s disease

(2017) P. Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Buckling Under Pressure: Curvature-Based Lipid Segregation and Stability Modulation in Cardiolipin-Containing Bilayers

(2017) Kevin J. Boyd et al.   LANGMUIR

Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy

(2017) Nikita Ikon et al.   LIPIDS

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

The ionization properties of cardiolipin and its variants in model bilayers

(2016) Murugappan Sathappa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Loss of protein association causes cardiolipin degradation in Barth syndrome

(2016) Yang Xu et al.   Nature Chemical Biology

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Novel advances in shotgun lipidomics for biology and medicine

(2016) Miao Wang et al.   PROGRESS IN LIPID RESEARCH

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

The complex nature of calcium cation interactions with phospholipid bilayers

(2016) Adéla Melcrová et al.   Scientific Reports

Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia

(2015) Alexander V. Birk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiolipin Interactions with Proteins

(2015) Joan Planas-Iglesias et al.   BIOPHYSICAL JOURNAL

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Naja naja oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic Three-Fingered Cytotoxins

(2015) Sardar E. Gasanov et al.   PLoS One

Structural and mechanical properties of cardiolipin lipid bilayers determined using neutron spin echo, small angle neutron and X-ray scattering, and molecular dynamics simulations

(2015) Jianjun Pan et al.   Soft Matter

Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes

(2015) Ya-Wen Lu et al.   Frontiers in Genetics

Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

(2014) M-S Hwang et al.   CELL DEATH AND DIFFERENTIATION

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols

(2013) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes

(2013) Eugenia Mileykovskaya et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Unremodeled and Remodeled Cardiolipin Are Functionally Indistinguishable in Yeast

(2013) Matthew G. Baile et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Membrane interactions of two arginine-rich peptides with different cell internalization capacities

(2012) Astrid Walrant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and dynamics of the two amphipathic arginine-rich peptides RW9 and RL9 in a lipid environment investigated by solid-state NMR and MD simulations

(2012) Kristina Witte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

Lipid packing variations induced by pH in cardiolipin-containing bilayers: The driving force for the cristae-like shape instability

(2011) Nada Khalifat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cytochrome c-Lipid Interactions: New Insights from Resonance Energy Transfer

(2010) Valeriya M. Trusova et al.   BIOPHYSICAL JOURNAL

Automated Lipid Identification and Quantification by Multidimensional Mass Spectrometry-Based Shotgun Lipidomics

(2009) Kui Yang et al.   ANALYTICAL CHEMISTRY

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

(2009) Ruthven N.A.H. Lewis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

Monitoring Biophysical Properties of Lipid Membranes by Environment-Sensitive Fluorescent Probes

(2009) Alexander P. Demchenko et al.   BIOPHYSICAL JOURNAL

Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia

(2009) Andrea Kopp Lugli et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Magic-angle phosphorus NMR of functional mitochondria: in situ monitoring of lipid response under apoptotic-like stress

(2009) Marc-Antoine Sani et al.   FASEB JOURNAL

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

(2009) Valerian E. Kagan et al.   FREE RADICAL BIOLOGY AND MEDICINE

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AFM and FTIR Spectroscopy Investigation of the Inverted Hexagonal Phase of Cardiolipin

(2009) Andrea Alessandrini et al.   JOURNAL OF PHYSICAL CHEMISTRY B

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Microfluidics-based electrospray ionization enhances the intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry: development of an automated high-throughput platform for shotgun lipidomics

(2008) Xianlin Han et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Quaternary Structure of the Mitochondrial TIM23 Complex Reveals Dynamic Association between Tim23p and Other Subunits

(2007) Nathan N. Alder et al.   MOLECULAR BIOLOGY OF THE CELL