Dynamical hallmarks of cancer: Phenotypic switching in melanoma and epithelial-mesenchymal plasticity

A cell fate reprogramming strategy reverses epithelial-to-mesenchymal transition of lung cancer cells while avoiding hybrid states

(2023) Namhee Kim et al.   CANCER RESEARCH

The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition

(2023) Ayalur Raghu Subbalakshmi et al.   Journal of Biological Engineering

The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance

(2023) Serena Diazzi et al.   Oncogenesis

Involvement of Epithelial–Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity

(2023) Sarah M. Groves et al.   Cancers

Boolean modeling of mechanosensitive epithelial to mesenchymal transition and its reversal

(2023) Emmalee Sullivan et al.   iScience

Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells

(2023) Yogesh Goyal et al.   NATURE

Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity

(2023) Seemadri Subhadarshini et al.   Journal for ImmunoTherapy of Cancer

Interconnected high-dimensional landscapes of epithelial–mesenchymal plasticity and stemness in cancer

(2022) Sarthak Sahoo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Roadmap on plasticity and epigenetics in cancer

(2022) Jasmine Foo et al.   PHYSICAL BIOLOGY

Synthetic multistability in mammalian cells

(2022) Ronghui Zhu et al.   SCIENCE

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

CTCF Expression and Dynamic Motif Accessibility Modulates Epithelial–Mesenchymal Gene Expression

(2022) Kelsey S. Johnson et al.   Cancers

Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation

(2022) Qing Zhang et al.   Science China-Life Sciences

Phenotypic plasticity during metastatic colonization

(2022) Charly Jehanno et al.   TRENDS IN CELL BIOLOGY

Epigenetic cell memory: The gene’s inner chromatin modification circuit

(2022) Simone Bruno et al.   PLoS Computational Biology

Computational Model of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes

(2022) Arran Hodgkinson et al.   Frontiers in Oncology

Nrf2 Modulates the Hybrid Epithelial/Mesenchymal Phenotype and Notch Signaling During Collective Cancer Migration

(2022) Samuel A. Vilchez Mercedes et al.   Frontiers in Molecular Biosciences

Emergence of hybrid states of stem-like cancer cells correlates with poor prognosis in oral cancer

(2022) Kavya Vipparthi et al.   iScience

Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning

(2022) Daniel B. Burkhardt et al.   Cancer Discovery

Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer

(2022) Meredith S. Brown et al.   Science Advances

Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis

(2022) Maalavika Pillai et al.   Frontiers in Oncology

Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFβ1 Promotes Tumour Growth

(2022) Mafalda Santos et al.   Biology-Basel

Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial—ECOG-ACRIN EA6134

(2022) Michael B. Atkins et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigenetic factor competition reshapes the EMT landscape

(2022) M. Ali Al-Radhawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of epithelial mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

(2022) Kishore Hari et al.   eLife

Network topology metrics explaining enrichment of hybrid epithelial/mesenchymal phenotypes in metastasis

(2022) Mubasher Rashid et al.   PLoS Computational Biology

Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanoma

(2022) Maalavika Pillai et al.   iScience

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

(2021) Sumaiyah K. Rehman et al.   CELL

MITF reprograms the extracellular matrix and focal adhesion in melanoma

(2021) Ramile Dilshat et al.   eLife

Non‐genetic heterogeneity, altered cell fate and differentiation therapy

(2021) Alexander C Lewis et al.   EMBO Molecular Medicine

Variability within rare cell states enables multiple paths toward drug resistance

(2021) Benjamin L. Emert et al.   NATURE BIOTECHNOLOGY

Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing

(2021) Abhijeet P. Deshmukh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer

(2021) Julienne L. Carstens et al.   Cell Reports

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer

(2021) Lakshya Chauhan et al.   eLife

A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2

(2021) Youyuan Deng et al.   Cancers

αvβ3 Integrin induces partial EMT independent of TGF-β signaling

(2021) Yoshinobu Kariya et al.   Communications Biology

Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

(2021) Oskar Marin-Bejar et al.   CANCER CELL

Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation

(2021) Nathaniel R. Campbell et al.   DEVELOPMENTAL CELL

Dynamic EMT: a multi‐tool for tumor progression

(2021) Simone Brabletz et al.   EMBO JOURNAL

Calcium signaling induces a partial EMT

(2021) Robert J Norgard et al.   EMBO REPORTS

Developmental chromatin programs determine oncogenic competence in melanoma

(2021) Arianna Baggiolini et al.   SCIENCE

An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability

(2021) Corey E. Hayford et al.   PLOS BIOLOGY

Dynamic self-reinforcement of gene expression determines acquisition of cellular mechanical memory

(2021) Christopher C. Price et al.   BIOPHYSICAL JOURNAL

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype

(2021) Sarthak Sahoo et al.   Frontiers in Immunology

Circulating Tumor Cell Clusters Are Cloaked with Platelets and Correlate with Poor Prognosis in Unresectable Pancreatic Cancer

(2021) Minji Lim et al.   Cancers

Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma

(2021) Maalavika Pillai et al.   iScience

Cooperative behaviour and phenotype plasticity evolve during melanoma progression

(2020) Emily J Rowling et al.   Pigment Cell & Melanoma Research

Hybrid epithelial-mesenchymal phenotypes are controlled by microenvironmental factors

(2020) Gianluca Selvaggio et al.   CANCER RESEARCH

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Treatment Options for Advanced Melanoma After Anti-PD-1 Therapy

(2020) Nalan Akgul Babacan et al.   Current Oncology Reports

Context specificity of the EMT transcriptional response

(2020) David P. Cook et al.   Nature Communications

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

(2020) Yapeng Su et al.   Nature Communications

Gene Networks with Transcriptional Bursting Recapitulate Rare Transient Coordinated High Expression States in Cancer

(2020) Lea Schuh et al.   Cell Systems

Primary Resistance to PD-1-Based Immunotherapy—A Study in 319 Patients with Stage IV Melanoma

(2020) Teresa Amaral et al.   Cancers

Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors

(2020) Sydney M. Shaffer et al.   CELL

Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters

(2020) Christian Umkehrer et al.   NATURE BIOTECHNOLOGY

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

(2020) Jasper Wouters et al.   NATURE CELL BIOLOGY

Identifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach

(2020) Kishore Hari et al.   npj Systems Biology and Applications

Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells

(2020) Cinzia Donato et al.   Cell Reports

NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype

(2020) Ayalur Raghu Subbalakshmi et al.   Frontiers in Oncology

Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology

(2020) Satwik Pasani et al.   Journal of Clinical Medicine

Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients

(2020) Zhen Lin et al.   Frontiers in Oncology

Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment

(2019) Xuefei Li et al.   Frontiers in Oncology

An enriched network motif family regulates multistep cell fate transitions with restricted reversibility

(2019) Yujie Ye et al.   PLoS Computational Biology

Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition

(2019) Yoko Katsuno et al.   Science Signaling

Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells

(2019) Jian Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation

(2019) Jason E. Long et al.   CELL DEATH AND DIFFERENTIATION

Defining the Hallmarks of Metastasis

(2019) Danny R. Welch et al.   CANCER RESEARCH

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

(2019) Anne C. Rios et al.   CANCER CELL

Single-cell Analysis Reveals a Preexisting Drug-Resistant Subpopulation in the Luminal Breast Cancer Subtype

(2019) Marta Prieto-Vila et al.   CANCER RESEARCH

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma

(2019) Monica Fedele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melanoma Progression Inhibits Pluripotency and Differentiation of Melanoma-Derived iPSCs Produces Cells with Neural-like Mixed Dysplastic Phenotype

(2019) Edgardo Castro-Pérez et al.   Stem Cell Reports

Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer

(2019) Bhatia et al.   Journal of Clinical Medicine

A biophysical model uncovers the size distribution of migrating cell clusters across cancer types

(2019) Federico Bocci et al.   CANCER RESEARCH

Heterophylly: Phenotypic Plasticity of Leaf Shape in Aquatic and Amphibious Plants

(2019) Gaojie Li et al.   Plants-Basel

Anticipating critical transitions in epithelial–hybrid-mesenchymal cell-fate determination

(2019) Sukanta Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution

(2019) Loukia G. Karacosta et al.   Nature Communications

A Nonquiescent “Idling” Population State in Drug-Treated, BRAF -Mutated Melanoma

(2018) B. Bishal Paudel et al.   BIOPHYSICAL JOURNAL

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

Long-Term Outcomes in Patients With BRAF V600–Mutant Metastatic Melanoma Who Received Dabrafenib Combined With Trametinib

(2018) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

(2018) Yejing Ge et al.   NATURE REVIEWS GENETICS

Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing

(2018) Zsofia Miskolczi et al.   ONCOGENE

Topography of epithelial–mesenchymal plasticity

(2018) Francesc Font-Clos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

(2018) Biwei Yang et al.   Nature Communications

Immunotherapy Resistance by Inflammation-Induced Dedifferentiation

(2018) Arnav Mehta et al.   Cancer Discovery

Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT

(2018) Joseph Cursons et al.   Cell Systems

Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity

(2018) Mohit Kumar Jolly et al.   Frontiers in Oncology

Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment

(2018) Kotryna Seip et al.   CANCER LETTERS

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome

(2018) Nataly Stylianou et al.   ONCOGENE

Immunomodulatory effects of BRAF and MEK inhibitors: Implications for Melanoma therapy

(2018) Marvin Kuske et al.   PHARMACOLOGICAL RESEARCH

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

(2018) Tyler Risom et al.   Nature Communications

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

(2018) Federico Bocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

(2018) Sébastien Corre et al.   Nature Communications

Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

(2018) Toni Celià-Terrassa et al.   Nature Communications

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

The GRHL2/ZEB Feedback Loop-A Key Axis in the Regulation of EMT in Breast Cancer

(2017) Steven M. Mooney et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine

(2017) Liang Cheng et al.   MODERN PATHOLOGY

EMT and MET: necessary or permissive for metastasis?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

(2017) Mohammad Fallahi‐Sichani et al.   Molecular Systems Biology

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance

(2017) Yapeng Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

(2017) Deepika Neelakantan et al.   Nature Communications

Microenvironment-derived factors driving metastatic plasticity in melanoma

(2017) Isabella S. Kim et al.   Nature Communications

Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features

(2017) Hiroki Sato et al.   Scientific Reports

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Controlled Three-Dimensional Tumor Microenvironments Recapitulate Phenotypic Features and Differential Drug Response in Early vs Advanced Stage Breast Cancer

(2017) Manjulata Singh et al.   ACS Biomaterials-Science & Engineering

Controlled Three-Dimensional Tumor Microenvironments Recapitulate Phenotypic Features and Differential Drug Response in Early vs Advanced Stage Breast Cancer

(2017) Manjulata Singh et al.   ACS Biomaterials Science & Engineering

Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity

(2016) Akshata R. Udyavar et al.   CANCER RESEARCH

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

(2016) Marcelo Boareto et al.   Journal of the Royal Society Interface

Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

(2016) Paolo A Ascierto et al.   LANCET ONCOLOGY

Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2

(2016) Jason A. Somarelli et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis

(2016) D H Peng et al.   ONCOGENE

Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape

(2016) Qin Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

(2016) Michael Ramirez et al.   Nature Communications

Stability of the hybrid epithelial/mesenchymal phenotype

(2016) Mohit Kumar Jolly et al.   Oncotarget

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma

(2016) Adrian Biddle et al.   EBioMedicine

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification

(2016) Vin Yee Chung et al.   Scientific Reports

Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis

(2015) M. Ruscetti et al.   CANCER RESEARCH

Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival

(2015) M. J. Schliekelman et al.   CANCER RESEARCH

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

(2015) M. H. Kim et al.   EMBO JOURNAL

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial

(2015) Georgina V Long et al.   LANCET

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

HDAC inhibition impedes epithelial–mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer

(2015) M Ruscetti et al.   ONCOGENE

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

(2015) Rachel Ramsdale et al.   Science Signaling

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

(2015) Stefanie Riesenberg et al.   Nature Communications

OVOL guides the epithelial-hybrid-mesenchymal transition

(2015) Dongya Jia et al.   Oncotarget

An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

(2015) Tian Hong et al.   PLoS Computational Biology

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

(2015) Rachel Ramsdale et al.   Science Signaling

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.

(2015) Mickaël Ohanna et al.   Oncotarget

Single-cell gene expression signatures reveal melanoma cell heterogeneity

(2014) M Ennen et al.   ONCOGENE

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

(2014) L Jiang et al.   ONCOGENE

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition

(2013) Xiao-Jun Tian et al.   BIOPHYSICAL JOURNAL

Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells

(2013) Jian Guan et al.   CANCER LETTERS

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

Tristability in Cancer-Associated MicroRNA-TF Chimera Toggle Switch

(2013) Mingyang Lu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

(2013) Hernan Roca et al.   PLoS One

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

(2013) R Y-J Huang et al.   Cell Death & Disease

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

(2013) Mizuki Yamamoto et al.   Nature Communications

All-trans retinoic acid activates E-cadherin expression via promoter hypomethylation in the human colon carcinoma HCT116 cells

(2012) Young-Ju Woo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

(2012) Alexandria M Haslehurst et al.   BMC CANCER

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

(2012) Jennifer Landsberg et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo

(2012) J. A. Somarelli et al.   RNA

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative

(2011) A. Biddle et al.   CANCER RESEARCH

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

(2011) Nicole Vincent Jordan et al.   CELL CYCLE

An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   MOLECULAR BIOLOGY OF THE CELL

Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

(2011) A. J. Armstrong et al.   MOLECULAR CANCER RESEARCH

Understanding gene circuits at cell-fate branch points for rational cell reprogramming

(2010) Joseph X. Zhou et al.   TRENDS IN GENETICS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Cancer attractors: A systems view of tumors from a gene network dynamics and developmental perspective

(2009) Sui Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States

(2008) K. S. Hoek et al.   CANCER RESEARCH

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

(2008) N. Dumont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistable Decision Switches for Flexible Control of Epigenetic Differentiation

(2008) Raúl Guantes et al.   PLoS Computational Biology