EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination

(2016) Tongchao Li et al.   PLoS Genetics

Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

(2015) Nicholas McGranahan et al.   CANCER CELL

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation

(2015) D. J. Drasin et al.   CANCER RESEARCH

The Eya1 Phosphatase Promotes Shh Signaling during Hindbrain Development and Oncogenesis

(2015) Adriana Eisner et al.   DEVELOPMENTAL CELL

The SIX1-EYA transcriptional complex as a therapeutic target in cancer

(2015) Melanie A Blevins et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Twist1 and Snail Link Hedgehog Signaling to Tumor-Initiating Cell-Like Properties and Acquired Chemoresistance Independently of ABC Transporters

(2015) Ying Kong et al.   STEM CELLS

LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway

(2015) Mingli Zhou et al.   STEM CELLS

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

(2015) Annelies Gonnissen et al.   Oncotarget

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

(2015) Dongsheng Gu et al.   Cancers

Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis

(2014) Deepika Neelakantan et al.   Cell Adhesion & Migration

Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

(2013) A. Jimeno et al.   CLINICAL CANCER RESEARCH

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling

(2013) Karol Lu et al.   DEVELOPMENTAL BIOLOGY

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

(2013) Scott X. Atwood et al.   NATURE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer

(2012) N. P. A. Devika Gunasinghe et al.   CANCER AND METASTASIS REVIEWS

Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog-Induced Transformation of Neural Cells

(2011) L. E. C. Wanshura et al.   CANCER RESEARCH

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

Hedgehog Signaling: Networking to Nurture a Promalignant Tumor Microenvironment

(2011) L. G. Harris et al.   MOLECULAR CANCER RESEARCH

Hedgehog Signaling in the Normal and Neoplastic Mammary Gland

(2010) Adriana P. Visbal et al.   CURRENT DRUG TARGETS

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site

(2010) Henry R. Maun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review: Targeting the Hedgehog pathway in cancer

(2010) Sachin Gupta et al.   Therapeutic Advances in Medical Oncology

Hedgehog signalling in breast cancer

(2009) M. Kasper et al.   CARCINOGENESIS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling

(2009) Douglas S. Micalizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL