- Home
- Publications
- Publication Search
- Publication Details
Title
Epigenetic factor competition reshapes the EMT landscape
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 42, Pages -
Publisher
Proceedings of the National Academy of Sciences
Online
2022-10-11
DOI
10.1073/pnas.2210844119
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis
- (2022) Yun Zhang et al. NATURE CELL BIOLOGY
- Epigenetic cell memory: The gene’s inner chromatin modification circuit
- (2022) Simone Bruno et al. PLoS Computational Biology
- Identifying Competition Phenotypes in Synthetic Biochemical Circuits
- (2022) M. Ali Al-Radhawi et al. IEEE Control Systems Letters
- Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction
- (2021) Yiran Guo et al. TRENDS IN GENETICS
- Not just a writer: PRC2 as a chromatin reader
- (2021) Michael Uckelmann et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution
- (2021) Christopher M. Weber et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors
- (2021) Shilpa S. Dhar et al. Oncotarget
- Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs
- (2021) Tomás Alarcón et al. PLoS Computational Biology
- Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin
- (2021) Wei Zhao et al. iScience
- Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks
- (2021) Amel Chaouch et al. MOLECULAR CELL
- Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation
- (2020) Delphine Douillet et al. NATURE GENETICS
- Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
- (2020) Wenqing Ren et al. Nature Communications
- EZH2: a novel target for cancer treatment
- (2020) Ran Duan et al. Journal of Hematology & Oncology
- Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT
- (2020) Wen Jia et al. Oncotarget
- Small molecule inhibitors of the prostate cancer target KMT2D
- (2020) Qi Yu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- EZH2-Targeted Therapies in Cancer: Hype or a Reality
- (2020) Marie-Lisa Eich et al. CANCER RESEARCH
- A mathematical model exhibiting the effect of DNA methylation on the stability boundary in cell-fate networks
- (2020) Tianchi Chen et al. Epigenetics
- A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation
- (2020) Jeannette Reinig et al. Nature Communications
- H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone
- (2020) Sima Khazaei et al. Cancer Discovery
- COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer
- (2019) Richard J. Fagan et al. CANCER LETTERS
- Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
- (2019) Kim Sneppen et al. Nature Communications
- Redistribution of EZH 2 promotes malignant phenotypes by rewiring developmental programmes
- (2019) Thomas Mortimer et al. EMBO REPORTS
- Quantifying the interplay between genetic and epigenetic regulations in stem cell development
- (2019) Yunbin Zhang et al. NEW JOURNAL OF PHYSICS
- A gene regulatory network to control EMT programs in development and disease
- (2019) Hassan Fazilaty et al. Nature Communications
- The Bivalent Genome: Characterization, Structure, and Regulation
- (2019) Enrique Blanco et al. TRENDS IN GENETICS
- Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution
- (2019) Loukia G. Karacosta et al. Nature Communications
- MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
- (2018) Shilpa S. Dhar et al. MOLECULAR CELL
- KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function
- (2018) Kinisha Gala et al. ONCOGENE
- PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools
- (2018) Huaiyu Mi et al. NUCLEIC ACIDS RESEARCH
- MLL3 enhances the transcription of PD-L1 and regulates anti-tumor immunity
- (2018) Wei Xiong et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Histone H3 lysine 4 methyltransferase KMT2D
- (2017) Eugene Froimchuk et al. GENE
- The Regulatory Capacity of Bivalent Genes—A Theoretical Approach
- (2017) Torsten Thalheim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification
- (2017) Deqing Hu et al. MOLECULAR CELL
- Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity
- (2017) Daniel Holoch et al. TRENDS IN BIOCHEMICAL SCIENCES
- PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs
- (2017) Yongli Shan et al. Nature Communications
- The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition
- (2017) Joseph H. Taube et al. Oncotarget
- Resource Competition Shapes the Response of Genetic Circuits
- (2017) Yili Qian et al. ACS Synthetic Biology
- Interrogating the topological robustness of gene regulatory circuits by randomization
- (2017) Bin Huang et al. PLoS Computational Biology
- Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma
- (2016) J. B. N. Dawkins et al. CANCER RESEARCH
- EMT: 2016
- (2016) M. Angela Nieto et al. CELL
- KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
- (2016) Siang-Yun Ang et al. DEVELOPMENT
- The interaction of PRC2 with RNA or chromatin is mutually antagonistic
- (2016) Manuel Beltran et al. GENOME RESEARCH
- A model for competition for ribosomes in the cell
- (2016) Alon Raveh et al. Journal of the Royal Society Interface
- Targeting EZH2 in cancer
- (2016) Kimberly H Kim et al. NATURE MEDICINE
- Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain
- (2016) Feng Tie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition
- (2016) Chaochen Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetic balance of gene expression by Polycomb and COMPASS families
- (2016) Andrea Piunti et al. SCIENCE
- Single-molecule decoding of combinatorially modified nucleosomes
- (2016) E. Shema et al. SCIENCE
- Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
- (2016) C. Lu et al. SCIENCE
- Nanog, Oct4 and Tet1 interplay in establishing pluripotency
- (2016) Victor Olariu et al. Scientific Reports
- Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer
- (2016) Anne Laugesen et al. Cold Spring Harbor Perspectives in Medicine
- MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer
- (2016) Christie C. Sze et al. Cold Spring Harbor Perspectives in Medicine
- An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells
- (2016) Marius Walter et al. eLife
- PRC2 mediated H3K27 methylations in cellular identity and cancer
- (2015) Eric Conway et al. CURRENT OPINION IN CELL BIOLOGY
- Chromatin signatures of cancer
- (2015) Marc A. Morgan et al. GENES & DEVELOPMENT
- Loss of HP1 causes depletion of H3K27me3 from facultative heterochromatin and gain of H3K27me2 at constitutive heterochromatin
- (2015) Kirsty Jamieson et al. GENOME RESEARCH
- Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
- (2015) Jiyuan Zhang et al. NATURE MEDICINE
- Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth
- (2015) Evelina Y. Basenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory
- (2014) Philipp A. Steffen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity
- (2013) Christine L. Chaffer et al. CELL
- Tristability in Cancer-Associated MicroRNA-TF Chimera Toggle Switch
- (2013) Mingyang Lu et al. JOURNAL OF PHYSICAL CHEMISTRY B
- The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers
- (2013) D. Hu et al. MOLECULAR AND CELLULAR BIOLOGY
- MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination
- (2013) M. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
- (2013) James P Reddington et al. GENOME BIOLOGY
- The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis
- (2012) Ali Shilatifard Annual Review of Biochemistry
- Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation
- (2012) W. Yuan et al. SCIENCE
- Epigenetic reprogramming and post-transcriptional regulation during the epithelial–mesenchymal transition
- (2012) Chung-Yin Wu et al. TRENDS IN GENETICS
- Antagonism between MES-4 and Polycomb Repressive Complex 2 Promotes Appropriate Gene Expression in C. elegans Germ Cells
- (2012) Laura J. Gaydos et al. Cell Reports
- Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in Arabidopsis thaliana
- (2012) Angelique Deleris et al. PLoS Genetics
- A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
- (2011) Leonardo Salmena et al. CELL
- Enhancer-PRE communication contributes to the expansion of gene expression domains in proliferating primordia
- (2011) L. Perez et al. DEVELOPMENT
- Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks
- (2011) Frank W. Schmitges et al. MOLECULAR CELL
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
- (2010) Diego Pasini et al. NUCLEIC ACIDS RESEARCH
- CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing
- (2009) F. Tie et al. DEVELOPMENT
- Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
- (2008) D. Pasini et al. GENES & DEVELOPMENT
- Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS
- (2008) M. Wu et al. MOLECULAR AND CELLULAR BIOLOGY
- Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors
- (2008) Fabio Mohn et al. MOLECULAR CELL
- Modelling and analysis of gene regulatory networks
- (2008) Guy Karlebach et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started