Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

NAB-paclitaxel and gemcitabine in metastatic pancreatic ductal adenocarcinoma (PDAC): from clinical trials to clinical practice

(2016) Ferdinando De Vita et al.   BMC CANCER

Therapeutic potential of taxanes in the treatment of metastatic pancreatic cancer

(2016) Radmila Lemstrova et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells

(2016) Benjamin K. Robinson et al.   Biology Open

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis

(2015) Cole R Drifka et al.   MODERN PATHOLOGY

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Addressing the challenges of pancreatic cancer: Future directions for improving outcomes

(2015) Manuel Hidalgo et al.   PANCREATOLOGY

Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis

(2015) Susan Morvaridi et al.   Scientific Reports

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Role of three-dimensional matrix stiffness in regulating the chemoresistance of hepatocellular carcinoma cells

(2014) Chang Liu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Acquisition of epithelial–mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells

(2014) Q Yang et al.   BRITISH JOURNAL OF CANCER

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

(2014) M Bartucci et al.   ONCOGENE

Desmoplasia and Chemoresistance in Pancreatic Cancer

(2014) Marvin Schober et al.   Cancers

Stromal disrupting effects of nab-paclitaxel in pancreatic cancer

(2013) R Alvarez et al.   BRITISH JOURNAL OF CANCER

Pancreas-Specific Cre Driver Lines and Considerations for Their Prudent Use

(2013) Mark A. Magnuson et al.   Cell Metabolism

The Winning Formulation: The Development of Paclitaxel in Pancreatic Cancer

(2013) W. W. Ma et al.   CLINICAL CANCER RESEARCH

Substrate stiffness regulates solubility of cellular vimentin

(2013) Maria E. Murray et al.   MOLECULAR BIOLOGY OF THE CELL

Genetically engineered mouse models of pancreatic adenocarcinoma

(2013) Carmen Guerra et al.   Molecular Oncology

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators

(2013) Xiaocan Guo et al.   Cell and Bioscience

Role of Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Is Tumor Budding the Missing Link?

(2013) Eva Karamitopoulou   Frontiers in Oncology

In This Issue

(2012)   CELL

The nanomechanical signature of breast cancer

(2012) Marija Plodinec et al.   Nature Nanotechnology

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

Epithelial to mesenchymal transition (EMT) biomarkers – E-cadherin, beta-catenin, APC and Vimentin – in oral squamous cell carcinogenesis and transformation

(2012) S.Y. Chaw et al.   ORAL ONCOLOGY

Down-Regulation of Yes Associated Protein 1 Expression Reduces Cell Proliferation and Clonogenicity of Pancreatic Cancer Cells

(2012) Caroline H. Diep et al.   PLoS One

Mouse models of pancreatic cancer

(2012) Marta Herreros-Villanueva   WORLD JOURNAL OF GASTROENTEROLOGY

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Experimental validation of atomic force microscopy-based cell elasticity measurements

(2011) Andrew R Harris et al.   NANOTECHNOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

BoneJ: Free and extensible bone image analysis in ImageJ

(2010) Michael Doube et al.   BONE

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

(2009) T. Arumugam et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Kinetic Investigation of the Inhibitory Effect of Gemcitabine on DNA Polymerization Catalyzed by Human Mitochondrial DNA Polymerase

(2008) Jason D. Fowler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY