Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing

Targeting invasive properties of melanoma cells

(2017) Imanol Arozarena et al.   FEBS Journal

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

(2017) Helen L. Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Risk-based Breast Cancer Screening

(2017) Christoph I. Lee et al.   MEDICAL CLINICS OF NORTH AMERICA

The Slow Cycling Phenotype: A Growing Problem for Treatment Resistance in Melanoma

(2017) Antonio Ahn et al.   MOLECULAR CANCER THERAPEUTICS

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

(2016) Michael P. Smith et al.   CANCER CELL

Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies

(2016) Min Hwan Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Integrin signalling regulates YAP and TAZ to control skin homeostasis

(2016) Ahmed Elbediwy et al.   DEVELOPMENT

Heatmapper: web-enabled heat mapping for all

(2016) Sasha Babicki et al.   NUCLEIC ACIDS RESEARCH

YAP and TAZ Take Center Stage in Cancer

(2015) Kun Zhang et al.   BIOCHEMISTRY

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest

(2015) L. J. Manderfield et al.   DEVELOPMENT

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

(2015) Nikki R. Paul et al.   JOURNAL OF CELL BIOLOGY

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy

(2015) Claudia Wellbrock et al.   Pigment Cell & Melanoma Research

The mechanical microenvironment in cancer: How physics affects tumours

(2015) Anika Nagelkerke et al.   SEMINARS IN CANCER BIOLOGY

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy

(2015) Helena Cirenajwis et al.   Oncotarget

Independent replication of a melanoma subtype gene signature and evaluation of its prognostic value and biological correlates in a population cohort

(2015) Jérémie Nsengimana et al.   Oncotarget

Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma

(2015) Linli Zhou et al.   Journal of Cancer

Physical, Spatial, and Molecular Aspects of Extracellular Matrix ofIn VivoNiches and Artificial Scaffolds Relevant to Stem Cells Research

(2015) Maria Akhmanova et al.   Stem Cells International

The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors

(2014) John E. Mahoney et al.   DEVELOPMENTAL CELL

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNF 

(2014) M. P. Smith et al.   Cancer Discovery

Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion

(2014) Anna Chapman et al.   Cell Reports

Melanoma Cells Revive an Embryonic Transcriptional Network to Dictate Phenotypic Heterogeneity

(2014) Niels Vandamme et al.   Frontiers in Oncology

Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma

(2013) Flore Nallet-Staub et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

(2012) Makiko Fujii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

(2012) Michael P. Smith et al.   JNCI-Journal of the National Cancer Institute

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf

(2011) Kerrie L. Taylor et al.   DEVELOPMENT

Different patterns of fibronectin and tenascin-C splice variants expression in primary and metastatic melanoma lesions

(2011) Katharina Frey et al.   EXPERIMENTAL DERMATOLOGY

Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance

(2011) Edward H. Flach et al.   MOLECULAR PHARMACEUTICS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance

(2010) Emi K. Nishimura et al.   Cell Stem Cell

Gene Expression Profiling-Based Identification of Molecular Subtypes in Stage IV Melanomas with Different Clinical Outcome

(2010) G. Jonsson et al.   CLINICAL CANCER RESEARCH

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination

(2009) S. Pinner et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Inhibition of PAX3 by TGF-β Modulates Melanocyte Viability

(2008) Guang Yang et al.   MOLECULAR CELL

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

(2008) Claudia Wellbrock et al.   PLoS One