Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology
Authors
Keywords
-
Journal
Journal of Clinical Medicine
Volume 10, Issue 1, Pages 60
Publisher
MDPI AG
Online
2020-12-28
DOI
10.3390/jcm10010060
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Multistability in the epithelial-mesenchymal transition network
- (2020) Ying Xin et al. BMC BIOINFORMATICS
- cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer
- (2020) Yuchao He et al. STEM CELLS
- A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells
- (2020) Shubham Tripathi et al. PLoS Computational Biology
- A Novel Approach for Quantifying Cancer Cells Showing Hybrid Epithelial/Mesenchymal States in Large Series of Tissue Samples: Towards a New Prognostic Marker
- (2020) Louis Godin et al. Cancers
- Hybrid Stem Cell States: Insights Into the Relationship Between Mammary Development and Breast Cancer Using Single-Cell Transcriptomics
- (2020) Tasha Thong et al. Frontiers in Cell and Developmental Biology
- Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT
- (2020) Wen Jia et al. Oncotarget
- Identifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach
- (2020) Kishore Hari et al. npj Systems Biology and Applications
- OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease, and Reprogramming
- (2020) Kritika Saxena et al. CELLS TISSUES ORGANS
- In vitro and in vivo characterization of cancer stem cell subpopulations in oral squamous cell carcinoma
- (2020) Nádia Ghinelli Amôr et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- Multi-stability in cellular differentiation enabled by a network of three mutually repressing master regulators
- (2020) Atchuta Srinivas Duddu et al. Journal of the Royal Society Interface
- Inference and multiscale model of epithelial-to-mesenchymal transition via single-cell transcriptomic data
- (2020) Yutong Sha et al. NUCLEIC ACIDS RESEARCH
- Local and global features of genetic networks supporting a phenotypic switch
- (2020) Aseel Shomar et al. PLoS One
- TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis
- (2020) Michaela Galoczova et al. VIRCHOWS ARCHIV
- Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells
- (2019) Cornelia Kröger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
- (2019) Dongya Jia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defining the Hallmarks of Metastasis
- (2019) Danny R. Welch et al. CANCER RESEARCH
- An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance
- (2019) Shengnan Xu et al. Journal of Clinical Medicine
- Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response
- (2019) Dongya Jia et al. Journal of Clinical Medicine
- Morphological State Transition Dynamics in EGF-Induced Epithelial to Mesenchymal Transition
- (2019) Vimalathithan Devaraj et al. Journal of Clinical Medicine
- Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
- (2019) Toni Celià-Terrassa et al. Cold Spring Harbor Perspectives in Medicine
- Cancer stem‐like cells with hybrid epithelial/mesenchymal phenotype leading the collective invasion
- (2019) Qianghua Quan et al. CANCER SCIENCE
- Topography of epithelial–mesenchymal plasticity
- (2018) Francesc Font-Clos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling
- (2018) Federico Bocci et al. Oncotarget
- Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling
- (2018) Justin A. Colacino et al. Stem Cell Reports
- Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity
- (2018) Mohit Kumar Jolly et al. Frontiers in Oncology
- Identification of the tumour transition states occurring during EMT
- (2018) Ievgenia Pastushenko et al. NATURE
- Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
- (2018) Mohit Kumar Jolly et al. PHARMACOLOGY & THERAPEUTICS
- High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling
- (2018) Donghyeok Kim et al. Cell Death & Disease
- Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers
- (2018) Ian MacFawn et al. MOLECULAR IMMUNOLOGY
- Beating tumour drug resistance: “Lamarckian” induction in the spotlight
- (2018) Carla Daniela Robles-Espinoza Pigment Cell & Melanoma Research
- Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
- (2018) Federico Bocci et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
- (2018) Toni Celià-Terrassa et al. Nature Communications
- EMT and MET: necessary or permissive for metastasis?
- (2017) Mohit Kumar Jolly et al. Molecular Oncology
- Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells
- (2017) Brian Bierie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
- (2017) Bogdan-Tiberius Preca et al. Oncotarget
- Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features
- (2017) Hiroki Sato et al. Scientific Reports
- Interrogating the topological robustness of gene regulatory circuits by randomization
- (2017) Bin Huang et al. PLoS Computational Biology
- Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells
- (2016) Wei Chen et al. CARCINOGENESIS
- Distinctive properties of metastasis-initiating cells
- (2016) Toni Celià-Terrassa et al. GENES & DEVELOPMENT
- Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2
- (2016) Jason A. Somarelli et al. MOLECULAR AND CELLULAR BIOLOGY
- Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-Mesenchymal Transition: Effects on Anoikis
- (2016) J. C. Farris et al. MOLECULAR CANCER RESEARCH
- Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome
- (2016) Satyendra C. Tripathi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stability of the hybrid epithelial/mesenchymal phenotype
- (2016) Mohit Kumar Jolly et al. Oncotarget
- Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition
- (2016) Valentine Comaills et al. Cell Reports
- GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification
- (2016) Vin Yee Chung et al. Scientific Reports
- A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells
- (2015) Bogdan-Tiberius Preca et al. INTERNATIONAL JOURNAL OF CANCER
- HDAC inhibition impedes epithelial–mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer
- (2015) M Ruscetti et al. ONCOGENE
- Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival
- (2015) Anne Grosse-Wilde et al. PLoS One
- Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
- (2015) Aaron Goldman et al. Nature Communications
- Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model
- (2015) Mohit Kumar Jolly et al. Oncotarget
- An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States
- (2015) Tian Hong et al. PLoS Computational Biology
- Mammary Morphogenesis and Regeneration Require the Inhibition of EMT at Terminal End Buds by Ovol2 Transcriptional Repressor
- (2014) Kazuhide Watanabe et al. DEVELOPMENTAL CELL
- Towards elucidating the connection between epithelial-mesenchymal transitions and stemness
- (2014) M. K. Jolly et al. Journal of the Royal Society Interface
- Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts
- (2014) Suling Liu et al. Stem Cell Reports
- Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog
- (2013) Violetta Karwacki-Neisius et al. Cell Stem Cell
- Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells
- (2013) Yujie Liu et al. PLoS One
- MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination
- (2013) M. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition
- (2013) M. Hafner et al. RNA
- Non-Darwinian dynamics in therapy-induced cancer drug resistance
- (2013) Angela Oliveira Pisco et al. Nature Communications
- Suppression of the Epithelial-Mesenchymal Transition by Grainyhead-like-2
- (2012) B. Cieply et al. CANCER RESEARCH
- Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
- (2012) Toni Celià-Terrassa et al. JOURNAL OF CLINICAL INVESTIGATION
- LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance
- (2012) Melissa L. Wilbert et al. MOLECULAR CELL
- Autoregulation of microRNA biogenesis by let-7 and Argonaute
- (2012) Dimitrios G. Zisoulis et al. NATURE
- Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis
- (2012) P Dong et al. ONCOGENE
- Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer
- (2011) R. Roylance et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer
- (2011) N. J. Birkbak et al. CANCER RESEARCH
- Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative
- (2011) A. Biddle et al. CANCER RESEARCH
- Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells
- (2010) X. Yang et al. CANCER RESEARCH
- Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions
- (2010) Thorold W. Theunissen et al. CURRENT BIOLOGY
- The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?
- (2010) Simone Brabletz et al. EMBO REPORTS
- Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells
- (2010) Dejuan Kong et al. PLoS One
- BioNumbers—the database of key numbers in molecular and cell biology
- (2009) Ron Milo et al. NUCLEIC ACIDS RESEARCH
- Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
- (2009) Caihong Qiu et al. NUCLEIC ACIDS RESEARCH
- A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition
- (2008) C. P. Bracken et al. CANCER RESEARCH
- Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth
- (2008) T. Tsuji et al. CANCER RESEARCH
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
- (2008) S.-M. Park et al. GENES & DEVELOPMENT
- Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
- (2008) Anne-Pierre Morel et al. PLoS One
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started