ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis
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Title
ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis
Authors
Keywords
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Journal
ONCOGENE
Volume 36, Issue 14, Pages 1925-1938
Publisher
Springer Nature
Online
2016-10-03
DOI
10.1038/onc.2016.358
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Note: Only part of the references are listed.- The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL
- (2016) Christin Ungewiss et al. Scientific Reports
- The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers
- (2015) S T Kundu et al. ONCOGENE
- Cancer statistics, 2014
- (2014) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
- (2014) Katherine A. Hoadley et al. CELL
- Molecular Pathways: Linking Tumor Microenvironment to Epithelial-Mesenchymal Transition in Metastasis
- (2014) H.-Y. Jung et al. CLINICAL CANCER RESEARCH
- ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism
- (2014) Yanan Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization
- (2014) G Canesin et al. ONCOGENE
- A pan-cancer proteomic perspective on The Cancer Genome Atlas
- (2014) Rehan Akbani et al. Nature Communications
- Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
- (2014) Limo Chen et al. Nature Communications
- LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
- (2013) T. R. Cox et al. CANCER RESEARCH
- Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas
- (2013) M. W. Pickup et al. CANCER RESEARCH
- Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling
- (2013) H. E. Barker et al. MOLECULAR CANCER RESEARCH
- Human Lung Epithelial Cells Progressed to Malignancy through Specific Oncogenic Manipulations
- (2013) Mitsuo Sato et al. MOLECULAR CANCER RESEARCH
- A Synthetic Matrix with Independently Tunable Biochemistry and Mechanical Properties to Study Epithelial Morphogenesis and EMT in a Lung Adenocarcinoma Model
- (2012) B. J. Gill et al. CANCER RESEARCH
- An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
- (2012) L. A. Byers et al. CLINICAL CANCER RESEARCH
- ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
- (2012) Young-Ho Ahn et al. JOURNAL OF CLINICAL INVESTIGATION
- Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition
- (2012) Jennifer L. Leight et al. MOLECULAR BIOLOGY OF THE CELL
- LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution
- (2011) H. E. Barker et al. CANCER RESEARCH
- The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice
- (2011) Yanan Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer
- (2011) Ann-Marie Baker et al. JNCI-Journal of the National Cancer Institute
- Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas
- (2011) Ping Zhan et al. MEDICAL ONCOLOGY
- An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
- (2011) Philip A. Gregory et al. MOLECULAR BIOLOGY OF THE CELL
- Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
- (2011) V Davalos et al. ONCOGENE
- Dynamic interplay between the collagen scaffold and tumor evolution
- (2010) Mikala Egeblad et al. CURRENT OPINION IN CELL BIOLOGY
- miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1
- (2010) J. D. Roybal et al. MOLECULAR CANCER RESEARCH
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
- (2010) Vivian Barry-Hamilton et al. NATURE MEDICINE
- LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
- (2010) Y. Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway
- (2009) Liang Peng et al. CARCINOGENESIS
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
- (2009) Kandice R. Levental et al. CELL
- Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
- (2009) D. L. Gibbons et al. GENES & DEVELOPMENT
- Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells
- (2009) Peter Hollosi et al. INTERNATIONAL JOURNAL OF CANCER
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
- (2009) Ulrich Wellner et al. NATURE CELL BIOLOGY
- Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma
- (2009) Don L. Gibbons et al. PLoS One
- Lysyl Oxidase-Like 2 as a New Poor Prognosis Marker of Squamous Cell Carcinomas
- (2008) H. Peinado et al. CANCER RESEARCH
- Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
- (2008) Jing Yang et al. DEVELOPMENTAL CELL
- The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
- (2008) Philip A. Gregory et al. NATURE CELL BIOLOGY
- Micromanagers of malignancy: role of microRNAs in regulating metastasis
- (2008) Li Ma et al. TRENDS IN GENETICS
- Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–β Signaling
- (2007) Yasushi Shintani et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
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