Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

RACIPE: a computational tool for modeling gene regulatory circuits using randomization

(2018) Bin Huang et al.   BMC Systems Biology

Mathematical modeling of cancer metabolism

(2018) Miguel Ángel Medina   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

From correlation to causation: analysis of metabolomics data using systems biology approaches

(2018) Antonio Rosato et al.   Metabolomics

Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells

(2018) Tariq Shah et al.   NMR IN BIOMEDICINE

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

(2018) Ilenia Pacella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

(2018) Dongya Jia et al.   Cells

Genome scale metabolic modeling of cancer

(2017) Avlant Nilsson et al.   METABOLIC ENGINEERING

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

(2017) Woosung Chung et al.   Nature Communications

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence

(2017) Katherine R. Singleton et al.   Cell Reports

Interrogating the topological robustness of gene regulatory circuits by randomization

(2017) Bin Huang et al.   PLoS Computational Biology

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism

(2017) Daniel C. Zielinski et al.   Scientific Reports

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling

(2016) X Tang et al.   ONCOGENE

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

HIF2 -Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

(2015) B. Qiu et al.   Cancer Discovery

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype

(2014) B Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutamate enrichment as new diagnostic opportunity in breast cancer

(2014) Jan Budczies et al.   INTERNATIONAL JOURNAL OF CANCER

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

(2014) K. Yizhak et al.   Molecular Systems Biology

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Bacterial Persister Cell Formation and Dormancy

(2013) Thomas K. Wood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion

(2013) T. R. Donti et al.   Disease Models & Mechanisms

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

(2013) Atsushi Terunuma et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

(2012) Jin Zhang et al.   Cell Stem Cell

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

Predicting selective drug targets in cancer through metabolic networks

(2011) O. Folger et al.   Molecular Systems Biology

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

Flux balance analysis of biological systems: applications and challenges

(2009) K. Raman et al.   BRIEFINGS IN BIOINFORMATICS

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Imagable 4T1 model for the study of late stage breast cancer

(2008) Kai Tao et al.   BMC CANCER

Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1  Differentially in Cancer and Ischemia

(2008) A. A. Qutub et al.   MOLECULAR AND CELLULAR BIOLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE