Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation

Distinct actin-dependent nanoscale assemblies underlie the dynamic and hierarchical organization of E-cadherin

(2021) Rumamol Chandran et al.   CURRENT BIOLOGY

Homophilic and heterophilic cadherin bond rupture forces in homo- or hetero-cellular systems measured by AFM-based single-cell force spectroscopy

(2021) Prem Kumar Viji Babu et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Activated nanoscale actin-binding domain motion in the catenin–cadherin complex revealed by neutron spin echo spectroscopy

(2021) Bela Farago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting differential effects of actomyosin contractility to control cell sorting among breast cancer cells

(2021) Alexander J. Devanny et al.   MOLECULAR BIOLOGY OF THE CELL

Anisotropic stiffness gradient-regulated mechanical guidance drives directional migration of cancer cells

(2020) Haihui Zhang et al.   Acta Biomaterialia

Comparative effects of N-cadherin protein and peptide fragments on mesenchymal stem cell mechanotransduction and paracrine function

(2020) Ellen C. Qin et al.   BIOMATERIALS

Spatiotemporal regulation of ∆Np63 by TGFβ-regulated miRNAs is essential for cancer metastasis

(2020) Ngoc H. B. Bui et al.   CANCER RESEARCH

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Leader Position of Mesenchymal Cells Expressing N-Cadherin in the Collective Migration of Epithelial Cancer

(2020) Inés Saénz-de-Santa-María et al.   Cells

Indirect co-culture of lung carcinoma cells with hyperthermia-treated mesenchymal stem cells influences tumor spheroid growth in a collagen-based 3-dimensional microfluidic model

(2020) Nandini Dhiman et al.   CYTOTHERAPY

Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer

(2019) Qinglei Gao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

(2019) Hyun Ju Hwang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors

(2019) Kyra Campbell et al.   Nature Communications

Biomaterial substrate-derived compact cellular spheroids mimicking the behavior of pancreatic cancer and microenvironment

(2019) Chui-Wei Wong et al.   BIOMATERIALS

Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas

(2019) Cuixia Yang et al.   ONCOGENE

Mechanisms of 3D cell migration

(2019) Kenneth M. Yamada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid

(2019) Yuji Nashimoto et al.   BIOMATERIALS

Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects

(2019) Taimoor H. Qazi et al.   BIOMATERIALS

Cancer stem‐like cells with hybrid epithelial/mesenchymal phenotype leading the collective invasion

(2019) Qianghua Quan et al.   CANCER SCIENCE

Co-culture of tumor spheroids and monocytes in a collagen matrix-embedded microfluidic device to study the migration of breast cancer cells

(2018) Tianying Yuan et al.   CHINESE CHEMICAL LETTERS

EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration

(2018) Nicole M. Aiello et al.   DEVELOPMENTAL CELL

Michael Abercrombie: contact inhibition of locomotion and more

(2018) Alice Roycroft et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Fibrotic microtissue array to predict anti-fibrosis drug efficacy

(2018) Mohammadnabi Asmani et al.   Nature Communications

Dose and Timing of N-Cadherin Mimetic Peptides Regulate MSC Chondrogenesis within Hydrogels

(2018) Mi Y. Kwon et al.   Advanced Healthcare Materials

Substrate Stiffness Coupling TGF-β1 Modulates Migration and Traction Force of MDA-MB-231 Human Breast Cancer Cells in Vitro

(2018) Feng Lin et al.   ACS Biomaterials-Science & Engineering

Substrate Stiffness Coupling TGF-β1 Modulates Migration and Traction Force of MDA-MB-231 Human Breast Cancer Cells in Vitro

(2018) Feng Lin et al.   ACS Biomaterials Science & Engineering

Contractility of Airway Smooth Muscle Cell in Response to Zinc Oxide Nanoparticles by Traction Force Microscopy

(2018) Feng Lin et al.   ANNALS OF BIOMEDICAL ENGINEERING

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

(2018) Medhavi Vishwakarma et al.   Nature Communications

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

(2018) Federico Bocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolving the cadherin–F-actin connection

(2017) Mitchell K. L. Han et al.   NATURE CELL BIOLOGY

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Mechanobiology of collective cell behaviours

(2017) Benoit Ladoux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breast tumor cell-specific knockout ofTwist1inhibits cancer cell plasticity, dissemination, and lung metastasis in mice

(2017) Yixiang Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life is 3D: Boosting Spheroid Function for Tissue Engineering

(2017) Matthias W. Laschke et al.   TRENDS IN BIOTECHNOLOGY

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A collective route to metastasis: Seeding by tumor cell clusters

(2016) K. J. Cheung et al.   SCIENCE

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Converging and Unique Mechanisms of Mechanotransduction at Adhesion Sites

(2016) Mitchell K.L. Han et al.   TRENDS IN CELL BIOLOGY

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

Tumor Budding: The Name is EMT. Partial EMT.

(2016) Alexandru Grigore et al.   Journal of Clinical Medicine

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program

(2015) Tuyen T. Dang et al.   CANCER RESEARCH

Inter-Cellular Forces Orchestrate Contact Inhibition of Locomotion

(2015) John R. Davis et al.   CELL

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

(2015) Sun-Ah Kim et al.   EXPERIMENTAL CELL RESEARCH

The evolutionary history of lethal metastatic prostate cancer

(2015) Gunes Gundem et al.   NATURE

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization

(2014) Srinivasa Raju Datla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface

(2014) P Bronsert et al.   JOURNAL OF PATHOLOGY

Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells

(2014) M. Reffay et al.   NATURE CELL BIOLOGY

Structural and energetic determinants of adhesive binding specificity in type I cadherins

(2014) Jeremie Vendome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chase-and-run between adjacent cell populations promotes directional collective migration

(2013) Eric Theveneau et al.   NATURE CELL BIOLOGY

Epithelial bridges maintain tissue integrity during collective cell migration

(2013) Sri Ram Krishna Vedula et al.   NATURE MATERIALS

Cellular Traction Force Reconstruction Based on a Self-adaptive Filtering Scheme

(2012) Jianyong Huang et al.   Cellular and Molecular Bioengineering

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility

(2012) Mei Rosa Ng et al.   JOURNAL OF CELL BIOLOGY

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Emerging modes of collective cell migration induced by geometrical constraints

(2012) S. R. K. Vedula et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E–N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells

(2011) Beate K. Straub et al.   JOURNAL OF CELL BIOLOGY

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Single-Cell Adhesion Tests against Functionalized Microspheres Arrayed on AFM Cantilevers Confirm Heterophilic E- and N-Cadherin Binding

(2010) Chawin Ounkomol et al.   BIOPHYSICAL JOURNAL

High-efficiency cell–substrate displacement acquisition via digital image correlation method using basis functions

(2010) Jianyong Huang et al.   OPTICS AND LASERS IN ENGINEERING

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

(2009) F van Zijl et al.   ONCOGENE