Non‐genetic heterogeneity, altered cell fate and differentiation therapy
Published 2021 View Full Article
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Title
Non‐genetic heterogeneity, altered cell fate and differentiation therapy
Authors
Keywords
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Journal
EMBO Molecular Medicine
Volume 13, Issue 3, Pages -
Publisher
EMBO
Online
2021-02-09
DOI
10.15252/emmm.202012670
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Note: Only part of the references are listed.- Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis
- (2020) Xiaotian Zhang et al. BLOOD
- Driver mutations in acute myeloid leukemia
- (2020) Ashwin Kishtagari et al. CURRENT OPINION IN HEMATOLOGY
- Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing
- (2020) Shamika Ketkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia
- (2020) Hannah J. Uckelmann et al. SCIENCE
- Tracing tumorigenesis in a solid tumor model at single-cell resolution
- (2020) Samantha D. Praktiknjo et al. Nature Communications
- DNA methylation disruption reshapes the hematopoietic differentiation landscape
- (2020) Franco Izzo et al. NATURE GENETICS
- Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness
- (2020) Elizabeth L. Ostrander et al. Stem Cell Reports
- Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
- (2020) Kiyomi Morita et al. Nature Communications
- Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
- (2019) Madison J. Kelly et al. Nature Communications
- Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis
- (2019) Matthew A. Loberg et al. LEUKEMIA
- Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
- (2019) Peter van Galen et al. CELL
- Understanding cell fate control by continuous single-cell quantification
- (2019) Dirk Loeffler et al. BLOOD
- Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia
- (2019) Daniel A. Pollyea et al. LEUKEMIA
- Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
- (2019) Anna M. Paczulla et al. NATURE
- Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
- (2019) Charles C. Bell et al. Nature Communications
- Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
- (2019) Mark D. McKenzie et al. Cell Stem Cell
- Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis
- (2019) Yorick Post et al. Cell Stem Cell
- Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells
- (2019) Dirk Loeffler et al. NATURE
- Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis
- (2019) Kyoko Ito et al. Cell Reports
- m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
- (2019) Yuanming Cheng et al. Cell Reports
- Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
- (2019) Theodore P. Braun et al. Nature Communications
- Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia
- (2019) Gail J. Roboz et al. BLOOD
- Principles and mechanisms of non-genetic resistance in cancer
- (2019) Charles C. Bell et al. BRITISH JOURNAL OF CANCER
- Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia
- (2019) Szymon Klossowski et al. JOURNAL OF CLINICAL INVESTIGATION
- Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma
- (2018) Joydeep Mukherjee et al. CANCER RESEARCH
- Toward Minimal Residual Disease-Directed Therapy in Melanoma
- (2018) Florian Rambow et al. CELL
- Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation
- (2018) Jason D. Buenrostro et al. CELL
- Modulating Cell Fate as a Therapeutic Strategy
- (2018) Brian Lin et al. Cell Stem Cell
- Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
- (2018) Amir Giladi et al. NATURE CELL BIOLOGY
- Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib
- (2018) Lynn Quek et al. NATURE MEDICINE
- Wild-type and mutated IDH1/2 enzymes and therapy responses
- (2018) Remco J. Molenaar et al. ONCOGENE
- Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence
- (2018) Allison L. Boyd et al. CANCER CELL
- Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
- (2018) Andrew M. Intlekofer et al. NATURE
- Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
- (2018) Courtney L. Jones et al. CANCER CELL
- Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy
- (2018) Ankur Sharma et al. Nature Communications
- Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition
- (2018) James J. Harding et al. Cancer Discovery
- A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML
- (2017) L M Kats et al. LEUKEMIA
- Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
- (2017) Alexander Raven et al. NATURE
- Polylox barcoding reveals haematopoietic stem cell fates realized in vivo
- (2017) Weike Pei et al. NATURE
- Human haematopoietic stem cell lineage commitment is a continuous process
- (2017) Lars Velten et al. NATURE CELL BIOLOGY
- Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
- (2017) Thomas Farge et al. Cancer Discovery
- Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2 - and TET2 -Mutant Acute Myeloid Leukemia
- (2017) Alan H. Shih et al. Cancer Discovery
- GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
- (2016) C. Pabst et al. BLOOD
- Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin
- (2016) N. Man et al. BLOOD
- Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
- (2016) R. Gardner et al. BLOOD
- Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
- (2016) David B. Sykes et al. CELL
- Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
- (2016) Paul W. Tetteh et al. Cell Stem Cell
- Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
- (2016) Andre Olsson et al. NATURE
- A 17-gene stemness score for rapid determination of risk in acute leukaemia
- (2016) Stanley W. K. Ng et al. NATURE
- Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios
- (2016) Philipp S. Hoppe et al. NATURE
- Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
- (2016) M Ryan Corces et al. NATURE GENETICS
- A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells
- (2016) Andreas Reinisch et al. NATURE MEDICINE
- Genomic Classification and Prognosis in Acute Myeloid Leukemia
- (2016) Elli Papaemmanuil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance
- (2016) K. Ito et al. SCIENCE
- Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
- (2016) I. Tirosh et al. SCIENCE
- CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
- (2016) Elad Jacoby et al. Nature Communications
- An Essential Role for the Transcription Factor Runx1 in T Cell Maturation
- (2016) Fan-Chi Hsu et al. Scientific Reports
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- (2015) O A Guryanova et al. LEUKEMIA
- Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
- (2015) Elaine E. Storm et al. NATURE
- BET inhibitor resistance emerges from leukaemia stem cells
- (2015) Chun Yew Fong et al. NATURE
- Effect of Mutation Order on Myeloproliferative Neoplasms
- (2015) Christina A. Ortmann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Developmental-stage-dependent transcriptional response to leukaemic oncogene expression
- (2015) Kakkad Regha et al. Nature Communications
- Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation
- (2014) A. Vitaliano-Prunier et al. BLOOD
- Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
- (2014) Jeffery M. Klco et al. CANCER CELL
- Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance
- (2014) Lev M. Kats et al. Cell Stem Cell
- Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
- (2014) Liran I. Shlush et al. NATURE
- The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
- (2014) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure
- (2014) Julien Ablain et al. NATURE MEDICINE
- Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
- (2014) Siddhartha Jaiswal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chromatin state dynamics during blood formation
- (2014) D. Lara-Astiaso et al. SCIENCE
- Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia
- (2014) Jianbiao Zhou World Journal of Stem Cells
- BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
- (2013) Eleni D. Lagadinou et al. Cell Stem Cell
- What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
- (2013) J.-A. Losman et al. GENES & DEVELOPMENT
- Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia
- (2013) Guilherme Augusto dos Santos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies
- (2013) Julien Ablain et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
- (2013) Francesco Lo-Coco et al. NEW ENGLAND JOURNAL OF MEDICINE
- (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
- (2013) J.-A. Losman et al. SCIENCE
- Immune evasion in acute myeloid leukemia: current concepts and future directions
- (2013) Ryan M Teague et al. Journal for ImmunoTherapy of Cancer
- The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia
- (2012) Versha Banerji et al. JOURNAL OF CLINICAL INVESTIGATION
- Cell of origin determines clinically relevant subtypes of MLL-rearranged AML
- (2012) A V Krivtsov et al. LEUKEMIA
- DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
- (2012) Christoph Bock et al. MOLECULAR CELL
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
- (2012) Keisuke Ito et al. NATURE MEDICINE
- Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2
- (2011) S. B. Ting et al. BLOOD
- The replication rate of human hematopoietic stem cells in vivo
- (2011) S. N. Catlin et al. BLOOD
- Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
- (2011) Kelly Moran-Crusio et al. CANCER CELL
- Dnmt3a is essential for hematopoietic stem cell differentiation
- (2011) Grant A Challen et al. NATURE GENETICS
- Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells
- (2010) Ann Mullally et al. CANCER CELL
- PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia
- (2010) Joost H.A. Martens et al. CANCER CELL
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