Computational Model of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes

Triple Therapy to Outwit the BRAF Oncogene

(2021) Chao Zhang et al.   Cancer Discovery

DREAMseq (Doublet, Randomized Evaluation in Advanced Melanoma Sequencing): A phase III trial—ECOG-ACRIN EA6134.

(2021) Michael B. Atkins et al.   JOURNAL OF CLINICAL ONCOLOGY

The potential of BRAF-targeted therapy combined with immunotherapy in melanoma

(2020) Sheida Naderi-Azad et al.   Expert Review of Anticancer Therapy

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

(2020) Jasper Wouters et al.   NATURE CELL BIOLOGY

The impact of BRAF mutation status on clinical outcomes with anti‐PD‐1 monotherapy versus combination ipilimumab/nivolumab in treatment‐naïve advanced stage melanoma

(2020) Vincent T. Ma et al.   Pigment Cell & Melanoma Research

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

(2019) Saran Kumar et al.   Cell Metabolism

Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma

(2019) Inna Smalley et al.   EBioMedicine

Computational Approaches and Analysis for a Spatio-Structural-Temporal Invasive Carcinoma Model

(2018) Arran Hodgkinson et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Signal Propagation in Sensing and Reciprocating Cellular Systems with Spatial and Structural Heterogeneity

(2018) Arran Hodgkinson et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

Spatio-Genetic and Phenotypic Modelling Elucidates Resistance and Re-Sensitisation to Treatment in Heterogeneous Melanoma

(2018) Arran Hodgkinson et al.   JOURNAL OF THEORETICAL BIOLOGY

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

(2017) Mohammad Fallahi‐Sichani et al.   Molecular Systems Biology

Targeting cancer with kinase inhibitors

(2015) Stefan Gross et al.   JOURNAL OF CLINICAL INVESTIGATION

RAF inhibitors that evade paradoxical MAPK pathway activation

(2015) Chao Zhang et al.   NATURE

Therapy-induced tumour secretomes promote resistance and tumour progression

(2015) Anna C. Obenauf et al.   NATURE

Mitochondrial oxidative stress is the achille’s heel of melanoma cells resistant to Braf-mutant inhibitor

(2015) Paola Corazao-Rozas et al.   Oncotarget

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

(2014) Chong Sun et al.   NATURE

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

(2013) Meghna Das Thakur et al.   NATURE

Mutant BRAF Melanomas—Dependence and Resistance

(2011) Poulikos I. Poulikakos et al.   CANCER CELL

A mathematical model for progression and heterogeneity in colorectal cancer dynamics

(2011) Marcello Delitala et al.   THEORETICAL POPULATION BIOLOGY