Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

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Reversal of pre-existing NGFR-driven tumor and immune therapy resistance

(2020) Julia Boshuizen et al.   Nature Communications

Comprehensive targeted next‐generation sequencing approach in the molecular diagnosis of gastrointestinal stromal tumor

(2020) Isabelle Vanden Bempt et al.   GENES CHROMOSOMES & CANCER

Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

(2019) Andrew Woolston et al.   CANCER CELL

Comprehensive Integration of Single-Cell Data

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Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma

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Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

(2019) Charles C. Bell et al.   Nature Communications

Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

(2019) Florian Rambow et al.   GENES & DEVELOPMENT

Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel

(2019) Guy Froyen et al.   Cancers

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

(2018) Charissa Kim et al.   CELL

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

Quantification of subclonal selection in cancer from bulk sequencing data

(2018) Marc J. Williams et al.   NATURE GENETICS

Harnessing Tumor Evolution to Circumvent Resistance

(2018) Katherine L. Pogrebniak et al.   TRENDS IN GENETICS

Immunotherapy Resistance by Inflammation-Induced Dedifferentiation

(2018) Arnav Mehta et al.   Cancer Discovery

Dabrafenib plus trametinib in BRAF K601E-mutant melanoma

(2018) A. Rogiers et al.   BRITISH JOURNAL OF DERMATOLOGY

Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions

(2018) Antoine Mousson et al.   Cancers

Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration

(2018) Ryan C. Ransom et al.   NATURE

Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models

(2017) Garima Khandelwal et al.   MOLECULAR CANCER RESEARCH

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

(2017) Mohammad Fallahi‐Sichani et al.   Molecular Systems Biology

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Tracing the origins of relapse in acute myeloid leukaemia to stem cells

(2017) Liran I. Shlush et al.   NATURE

An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer

(2017) Yaohua Xue et al.   NATURE MEDICINE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance

(2017) Yapeng Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

(2017) Ayano Kondo et al.   Cell Reports

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

(2017) Takahiro Tsujikawa et al.   Cell Reports

Principles of Reconstructing the Subclonal Architecture of Cancers

(2017) Stefan C. Dentro et al.   Cold Spring Harbor Perspectives in Medicine

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

(2015) Willy Hugo et al.   CELL

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

(2015) Lawrence N. Kwong et al.   JOURNAL OF CLINICAL INVESTIGATION

BET inhibitor resistance emerges from leukaemia stem cells

(2015) Chun Yew Fong et al.   NATURE

Erratum: A stress-induced early innate response causes multidrug tolerance in melanoma

(2015) D Ravindran Menon et al.   ONCOGENE

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis

(2015) Florian Rambow et al.   Cell Reports

Emerging Roles of Focal Adhesion Kinase in Cancer

(2015) Yu-Ling Tai et al.   Biomed Research International

Inhibitor of DNA Binding 4 (ID4) Is Highly Expressed in Human Melanoma Tissues and May Function to Restrict Normal Differentiation of Melanoma Cells

(2015) Yuval Peretz et al.   PLoS One

Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma

(2015) Francesco Spagnolo et al.   Oncotarget

BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

(2014) H. Rizos et al.   CLINICAL CANCER RESEARCH

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

(2014) Birgit Knoechel et al.   NATURE GENETICS

Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma

(2014) Georgina V. Long et al.   Nature Communications

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

(2012) Jennifer Landsberg et al.   NATURE

Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth

(2011) G. Civenni et al.   CANCER RESEARCH

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-  and integrin/focal adhesion kinase (FAK) signaling

(2011) M. Schober et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

(2010) Alexander D. Boiko et al.   NATURE

Allele-specific copy number analysis of tumors

(2010) P. Van Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GDNF and GFRα: a versatile molecular complex for developing neurons

(2008) Gustavo Paratcha et al.   TRENDS IN NEUROSCIENCES

Mechanisms of Disease: cancer stem cells—targeting the evil twin

(2008) Andreas Trumpp et al.   Nature clinical practice. Oncology