Dynamic EMT: a multi‐tool for tumor progression

Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target

(2021) Sven Jonckheere et al.   CELLS TISSUES ORGANS

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

Deeper Insight in Metastatic Cancer progression;Epithelial-to-Mesenchymal Transition and Genomic Instability: implications on treatment resistance

(2021) Kenneth Omabe et al.   CURRENT MOLECULAR MEDICINE

The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma

(2021) Manuel Ruh et al.   JOURNAL OF PATHOLOGY

Targeting Oncoimmune Drivers of Cancer Metastasis

(2021) Chie Kudo-Saito et al.   Cancers

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling

(2020) Weiwei Sheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epithelial-mesenchymal transition gene signature is associated with prognosis and tumor microenvironment in head and neck squamous cell carcinoma

(2020) Ah Ra Jung et al.   Scientific Reports

Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

(2020) József Dudás et al.   Cells

The Engagement Between MDSCs and Metastases: Partners in Crime

(2020) Rosalinda Trovato et al.   Frontiers in Oncology

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

(2020) Arianna Fumagalli et al.   Cell Stem Cell

Glucose Metabolism Takes Center Stage in Epithelial-Mesenchymal Plasticity

(2020) Khalil Kass Youssef et al.   DEVELOPMENTAL CELL

Twist1 induces chromosomal instability (CIN) in colorectal cancer cells

(2020) Maithilee Khot et al.   HUMAN MOLECULAR GENETICS

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EMT Factors and Metabolic Pathways in Cancer

(2020) Ilias Georgakopoulos-Soares et al.   Frontiers in Oncology

Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy

(2020) Nai-Yun Sun et al.   Frontiers in Oncology

Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

(2020) Nora Feldker et al.   EMBO JOURNAL

What makes leader cells arise: Intrinsic properties and support from neighboring cells

(2020) Bing‐Jun Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer

(2020) Ylia Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

TGFβ biology in cancer progression and immunotherapy

(2020) Rik Derynck et al.   Nature Reviews Clinical Oncology

Twist-mediated PAR1 induction is required for breast cancer progression and metastasis by inhibiting Hippo pathway

(2020) Yifan Wang et al.   Cell Death & Disease

CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils

(2020) Zheying Mao et al.   Oncogenesis

Hypoxia-induced epithelial to mesenchymal transition in cancer

(2020) Robert Y. Hapke et al.   CANCER LETTERS

A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer

(2020) Mohammed H. Mosa et al.   CANCER RESEARCH

EMT transcription factor ZEB1 represses the mutagenic POLθ-mediated end-joining pathway in breast cancers

(2020) Mélanie K. Prodhomme et al.   CANCER RESEARCH

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

(2020) Ievgenia Pastushenko et al.   NATURE

Tumor-Associated Neutrophils and Macrophages—Heterogenous but Not Chaotic

(2020) Ling Wu et al.   Frontiers in Immunology

Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis

(2019) Dana Ishay-Ronen et al.   CANCER CELL

Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells

(2019) Sen Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

(2019) Lu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

(2019) Cassandra Ringuette Goulet et al.   BMC CANCER

Role of Metabolic Reprogramming in Epithelial–Mesenchymal Transition (EMT)

(2019) Hyunkoo Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

(2019) Mark Esposito et al.   NATURE CELL BIOLOGY

Contribution of Epithelial Plasticity to Therapy Resistance

(2019) Patricia G. Santamaría et al.   Journal of Clinical Medicine

The Hippo Signaling Pathway in Pancreatic Cancer

(2019) DANIEL ANSARI et al.   ANTICANCER RESEARCH

Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer

(2019) Hua Wang et al.   CELL

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

(2019) Yang Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

(2019) Kayla M. Gross et al.   Cell Reports

Myeloid-Derived Suppressor Cells Promote Metastasis in Breast Cancer After the Stress of Operative Removal of the Primary Cancer

(2019) Xuelei Ma et al.   Frontiers in Oncology

PRRX1‐induced epithelial‐to‐mesenchymal transition in salivary adenoid cystic carcinoma activates the metabolic reprogramming of free fatty acids to promote invasion and metastasis

(2019) Ya‐ping Jiang et al.   CELL PROLIFERATION

M2‐polarized tumor‐associated macrophages promote epithelial‐mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma

(2019) Dalong Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia modulates stem cell properties and induces EMT through N ‐glycosylation of EpCAM in breast cancer cells

(2019) Dandan Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment–colorectal cancer network

(2019) Takeshi Ieda et al.   Scientific Reports

Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT

(2019) Laura Bornes et al.   Cell Reports

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

(2019) Maria Teresa Masucci et al.   Frontiers in Oncology

Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion

(2019) Yuanyuan Jiang et al.   CANCER LETTERS

TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer

(2019) Wan Hua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

ZEB1 inhibition sensitizes cells to the ATR inhibitor VE-821 by abrogating epithelial–mesenchymal transition and enhancing DNA damage

(2018) Na Song et al.   CELL CYCLE

The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome

(2018) Andrew D. Redfern et al.   CLINICAL & EXPERIMENTAL METASTASIS

EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration

(2018) Nicole M. Aiello et al.   DEVELOPMENTAL CELL

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

YAP and TAZ are essential for basal and squamous cell carcinoma initiation

(2018) Maud Debaugnies et al.   EMBO REPORTS

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM

(2018) Xiang Zhang et al.   Cell Death & Disease

Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

(2018) Mana Taki et al.   Nature Communications

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

(2018) Anassuya Ramachandran et al.   eLife

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer

(2018) Zachary A. Yochum et al.   ONCOGENE

Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

(2018) Chih-Chan Lee et al.   Nature Communications

EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer

(2018) Eugene Tulchinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tumor-contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop

(2018) Ying Wang et al.   CLINICAL CANCER RESEARCH

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Non-redundant functions of EMT transcription factors

(2018) Marc P. Stemmler et al.   NATURE CELL BIOLOGY

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

The STAT3/Slug Axis Enhances Radiation-Induced Tumor Invasion and Cancer Stem-like Properties in Radioresistant Glioblastoma

(2018) Jang-Chun Lin et al.   Cancers

Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE 2 /β-catenin signalling pathway

(2017) Dehai Che et al.   MOLECULAR IMMUNOLOGY

ZEB1-regulated inflammatory phenotype in breast cancer cells

(2017) Akihiro Katsura et al.   Molecular Oncology

New insights into the role of EMT in tumor immune escape

(2017) Stéphane Terry et al.   Molecular Oncology

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

(2017) Anne-Pierre Morel et al.   NATURE MEDICINE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells

(2017) C Pistore et al.   ONCOGENE

An integrated analysis identifies STAT4 as a key regulator of ovarian cancer metastasis

(2017) L Zhao et al.   ONCOGENE

Breast tumor cell-specific knockout ofTwist1inhibits cancer cell plasticity, dissemination, and lung metastasis in mice

(2017) Yixiang Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

(2017) Joan Seoane et al.   Cold Spring Harbor Perspectives in Biology

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

(2017) Mitsuteru Natsuizaka et al.   Nature Communications

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

(2017) Maria Ouzounova et al.   Nature Communications

Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells

(2017) Jun Sakata et al.   Oncotarget

Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in cancer

(2017) Shyam Kumar Gudey et al.   Oncotarget

CXCR2+ MDSCs promote breast cancer progression by inducing EMT and activated T cell exhaustion

(2017) Ha Zhu et al.   Oncotarget

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

(2017) Muhammad Zaeem Noman et al.   OncoImmunology

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

(2016) Xiaozhen He et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Fumarate drives EMT in renal cancer

(2016) Marco Sciacovelli et al.   CELL DEATH AND DIFFERENTIATION

ZEB1‐mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

(2016) Geoffrey Richard et al.   EMBO Molecular Medicine

Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization

(2016) Shigetsugu Takano et al.   GENES & DEVELOPMENT

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

(2016) Jill E. Larsen et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling

(2016) Yasushi Shintani et al.   Journal of Thoracic Oncology

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

(2016) Satyendra C. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

(2016) Waltraut Lehmann et al.   Nature Communications

EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells

(2016) Jinkyoung Kim et al.   Oncotarget

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis

(2015) M. Ruscetti et al.   CANCER RESEARCH

Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion

(2015) Dominik Nörz et al.   CELLULAR SIGNALLING

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

(2015) S. Meidhof et al.   EMBO Molecular Medicine

The Hippo transducer TAZ promotes epithelial to mesenchymal transition and cancer stem cell maintenance in oral cancer

(2015) Zhongwu Li et al.   Molecular Oncology

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

PAK5-mediated E47 phosphorylation promotes epithelial–mesenchymal transition and metastasis of colon cancer

(2015) G Zhu et al.   ONCOGENE

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

(2015) Vignesh Sundararajan et al.   Oncotarget

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization

(2015) Yaiza del Pozo Martin et al.   Cell Reports

CD4+T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells–novel implications of CD4+T cells in pancreatic cancer development

(2015) Lisa Goebel et al.   OncoImmunology

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Aritro Nath et al.   Scientific Reports

Regulation of Membrane-Type 4 Matrix Metalloproteinase by SLUG Contributes to Hypoxia-Mediated Metastasis

(2015) Chi-Hung Huang et al.   NEOPLASIA

Notch3 is important for TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancer bone metastasis by regulating ZEB-1

(2014) L Liu et al.   CANCER GENE THERAPY

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

(2014) Yoav D. Shaul et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma

(2014) JIN-WEI MIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition

(2014) M. Diepenbruck et al.   JOURNAL OF CELL SCIENCE

Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

(2014) Xun Yuan et al.   Journal of Hematology & Oncology

Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer

(2014) Maria Angelica Cortez et al.   MOLECULAR THERAPY

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

(2014) Peijing Zhang et al.   NATURE CELL BIOLOGY

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction

(2014) D-W Wu et al.   ONCOGENE

Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis

(2014) Yongqing Liu et al.   Nature Communications

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

(2014) Carine Gubelmann et al.   eLife

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

(2013) Y Yu et al.   BRITISH JOURNAL OF CANCER

An Integrin-Linked Machinery of Cytoskeletal Regulation that Enables Experimental Tumor Initiation and Metastatic Colonization

(2013) Tsukasa Shibue et al.   CANCER CELL

Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell-Mediated Lysis

(2013) I. Akalay et al.   CANCER RESEARCH

Mesenchymal phenotype after chemotherapy is associated with chemoresistance and poor clinical outcome in esophageal cancer

(2013) JOHJI HARA et al.   ONCOLOGY REPORTS

Downregulation of miR-200a Induces EMT Phenotypes and CSC-like Signatures through Targeting the β-catenin Pathway in Hepatic Oval Cells

(2013) Jie Liu et al.   PLoS One

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Tumour angiogenesis regulation by the miR-200 family

(2013) Chad V. Pecot et al.   Nature Communications

Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread epithelial to mesenchymal transition in the surviving tumor

(2013) Theodora Fifis et al.   Cancer Medicine

Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205

(2012) Martin Puhr et al.   AMERICAN JOURNAL OF PATHOLOGY

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

(2012) Anne-Katrine Bonde et al.   BMC CANCER

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

(2012) L. A. Byers et al.   CLINICAL CANCER RESEARCH

TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

(2012) S. Lamouille et al.   JOURNAL OF CELL SCIENCE

Early events in cell adhesion and polarity during epithelial-mesenchymal transition

(2012) R. Y.-J. Huang et al.   JOURNAL OF CELL SCIENCE

Inhibition of ZEB1 reverses EMT and chemoresistance in docetaxel-resistant human lung adenocarcinoma cell line

(2012) Jin Ren et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation

(2012) Yijing Li et al.   Molecular Cancer

TNF-  Induces Epithelial-Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3 -Dependent Mechanism

(2012) M.-Y. Ho et al.   MOLECULAR CANCER RESEARCH

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

(2012) Zhenfeng Zhang et al.   NATURE GENETICS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

(2012) Anne-Pierre Morel et al.   PLoS Genetics

SFRP1 reduction results in an increased sensitivity to TGF-β signaling

(2011) Kelly J Gauger et al.   BMC CANCER

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression

(2011) Marcus E. Peter   CELL CYCLE

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells

(2011) Simone Brabletz et al.   EMBO JOURNAL

Epithelial-mesenchymal transition in breast cancer lines is mediated through PDGF-D released by tissue-resident stem cells

(2011) Eswaran Devarajan et al.   INTERNATIONAL JOURNAL OF CANCER

Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells

(2011) Mian Xie et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

(2011) Eleni Makrodouli et al.   Molecular Cancer

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

(2011) Manav Korpal et al.   NATURE MEDICINE

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters

(2011) M Saxena et al.   Cell Death & Disease

Antiestrogens Induce Transforming Growth Factor  -Mediated Immunosuppression in Breast Cancer

(2010) C. M. Joffroy et al.   CANCER RESEARCH

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

(2010) Sejeong Shin et al.   MOLECULAR CELL

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells

(2009) M. Santisteban et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

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