Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity

Leveraging and coping with uncertainty in the response of individual cells to therapy

(2018) José Reyes et al.   CURRENT OPINION IN BIOTECHNOLOGY

Resolvins suppress tumor growth and enhance cancer therapy

(2017) Megan L. Sulciner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complexity: the organizing principle at the interface of biological (dis)order

(2017) Ramray Bhat et al.   JOURNAL OF GENETICS

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling

(2017) Federico Bocci et al.   Journal of the Royal Society Interface

Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments

(2017) Coco van Boxtel et al.   Journal of the Royal Society Interface

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

(2017) Prakash Kulkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance

(2017) Yapeng Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

(2017) Ping Mu et al.   SCIENCE

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

(2017) Sheng Yu Ku et al.   SCIENCE

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells

(2017) Arun K. Rooj et al.   Cell Reports

Cancer cells exhibit clonal diversity in phenotypic plasticity

(2017) Robert Austin Mathis et al.   Open Biology

Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory

(2017) Dongya Jia et al.   Cancers

Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate Cancer

(2017) Daisuke Obinata et al.   Cancers

Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress

(2017) Gilad Yaakov et al.   Nature Ecology & Evolution

A review of continuous vs intermittent androgen deprivation therapy: Redefining the gold standard in the treatment of advanced prostate cancer. Myths, facts and new data on a perpetual dispute

(2017) Zisis Kratiras et al.   International Braz J Urol

Phenotypic plasticity in prostate cancer: role of intrinsically disordered proteins

(2016) StevenM Mooney et al.   ASIAN JOURNAL OF ANDROLOGY

Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer

(2016) Prakash Kulkarni et al.   ASIAN JOURNAL OF ANDROLOGY

Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells

(2016) Min Yang et al.   BMC CANCER

Stochastic modeling suggests that noise reduces differentiation efficiency by inducing a heterogeneous drug response in glioma differentiation therapy

(2016) Xiaoqiang Sun et al.   BMC Systems Biology

Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity

(2016) Akshata R. Udyavar et al.   CANCER RESEARCH

Molecular mechanisms and clinical implications of bacterial persistence

(2016) Joran Elie Michiels et al.   DRUG RESISTANCE UPDATES

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

(2016) Marcelo Boareto et al.   Journal of the Royal Society Interface

HER2 expression identifies dynamic functional states within circulating breast cancer cells

(2016) Nicole Vincent Jordan et al.   NATURE

Shapeshifters in cancer: How some tumor cells change phenotype to evade therapy

(2016) Amanda B Keener   NATURE MEDICINE

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

(2016) Aaron N Hata et al.   NATURE MEDICINE

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche

(2016) K Shahriari et al.   ONCOGENE

Mechanisms of bacterial persistence during stress and antibiotic exposure

(2016) Alexander Harms et al.   SCIENCE

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

(2016) Michael Ramirez et al.   Nature Communications

Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer

(2016) Kristine M. Wadosky et al.   Oncotarget

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

(2016) Anna Segerman et al.   Cell Reports

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Stochastic expression of a multiple antibiotic resistance activator confers transient resistance in single cells

(2016) Imane El Meouche et al.   Scientific Reports

Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: ‘What does not kill me strengthens me’

(2015) A O Pisco et al.   BRITISH JOURNAL OF CANCER

Five critical elements to ensure the precision medicine

(2015) Chengshui Chen et al.   CANCER AND METASTASIS REVIEWS

Evidence Suggesting That Discontinuous Dosing of ALK Kinase Inhibitors May Prolong Control of ALK+ Tumors

(2015) A. D. Amin et al.   CANCER RESEARCH

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer

(2015) Michael D. Brooks et al.   Cell Stem Cell

PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate

(2015) Roberta Ferraldeschi et al.   EUROPEAN UROLOGY

Tumor mechanics and metabolic dysfunction

(2015) Jason C. Tung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen

(2015) Yanan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines

(2015) Margaretha A. Skowron et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Operating principles of Notch–Delta–Jagged module of cell–cell communication

(2015) Mohit Kumar Jolly et al.   NEW JOURNAL OF PHYSICS

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors

(2015) V Gibaja et al.   ONCOGENE

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision

(2015) Marcelo Boareto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: Results from a pilot clinical study

(2015) M. T. Schweizer et al.   Science Translational Medicine

Intrinsically disordered proteins and multicellular organisms

(2015) A. Keith Dunker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis

(2015) Bin Huang et al.   Scientific Reports

Prostate Cancer and Neuroendocrine Differentiation: More Neuronal, Less Endocrine?

(2015) Alexandru Dan Grigore et al.   Frontiers in Oncology

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Neuroendocrine Differentiation in Prostate Cancer: A Mechanism of Radioresistance and Treatment Failure

(2015) Chang-Deng Hu et al.   Frontiers in Oncology

Continuous versus intermittent chemotherapy strategies in metastatic colorectal cancer: a systematic review and meta-analysis

(2014) S. R. Berry et al.   ANNALS OF ONCOLOGY

Cancer/Testis Antigen PAGE4, a Regulator of c-Jun Transactivation, Is Phosphorylated by Homeodomain-Interacting Protein Kinase 1, a Component of the Stress-Response Pathway

(2014) Steven M. Mooney et al.   BIOCHEMISTRY

The impact of intra-clonal heterogeneity on the treatment of multiple myeloma

(2014) Annamaria Brioli et al.   BRITISH JOURNAL OF HAEMATOLOGY

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage

(2014) M.-E. Torres-Padilla et al.   DEVELOPMENT

Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

(2014) Elsa Abranches et al.   DEVELOPMENT

Correlation of Sprouty1 and Jagged1 With Aggressive Prostate Cancer Cells With Different Sensitivities to Androgen Deprivation

(2014) Naoki Terada et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness

(2014) M. K. Jolly et al.   Journal of the Royal Society Interface

Tumour heterogeneity and the evolution of polyclonal drug resistance

(2014) Rebecca A. Burrell et al.   Molecular Oncology

Phenotypic bistability in Escherichia coli's central carbon metabolism

(2014) O. Kotte et al.   Molecular Systems Biology

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

(2014) Chong Sun et al.   NATURE

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

(2014) Birgit Knoechel et al.   NATURE GENETICS

Acquired resistance to TKIs in solid tumours: learning from lung cancer

(2014) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

The Notch ligand Jagged1 as a target for anti-tumor therapy

(2014) Demin Li   Frontiers in Oncology

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation

(2013) Krithika Rajagopalan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

(2013) Meghna Das Thakur et al.   NATURE

Growth feedback as a basis for persister bistability

(2013) J. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype

(2013) R. A. Fasani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Responses in Prokaryotes: Regulating Gene Expression, Modulating Growth Patterns, and Manipulating Replication Forks

(2013) K. N. Kreuzer   Cold Spring Harbor Perspectives in Biology

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

(2013) E. M. Van Allen et al.   Cancer Discovery

Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

(2013) Prerna Malaney et al.   Scientific Reports

Modeling the Mechanics of Cancer: Effect of Changes in Cellular and Extra-Cellular Mechanical Properties

(2013) Parag Katira et al.   Frontiers in Oncology

PAGE4 Positivity Is Associated with Attenuated AR Signaling and Predicts Patient Survival in Hormone-Naive Prostate Cancer

(2012) Natalie Sampson et al.   AMERICAN JOURNAL OF PATHOLOGY

Mathematically modelling and controlling prostate cancer under intermittent hormone therapy

(2012) Yoshito Hirata et al.   ASIAN JOURNAL OF ANDROLOGY

Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation—diversity, ductility, and destiny

(2012) Kenichi Suda et al.   CANCER AND METASTASIS REVIEWS

Intrinsically disordered proteins and conformational noise

(2012) Gita Mahmoudabadi et al.   CELL CYCLE

Genetic heterogeneity and cancer drug resistance

(2012) Nicholas C Turner et al.   LANCET ONCOLOGY

Successful rechallenge in two patients with BRAF-V600-mutant melanoma who experienced previous progression during treatment with a selective BRAF inhibitor

(2012) Amélie Clémentine Seghers et al.   MELANOMA RESEARCH

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

(2012) Cecilia Andresen et al.   NUCLEIC ACIDS RESEARCH

Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer

(2012) John T. Isaacs et al.   PROSTATE

Bacterial survival strategies suggest rethinking cancer cooperativity

(2012) Eshel Ben-Jacob et al.   TRENDS IN MICROBIOLOGY

Nonheritable Cellular Variability Accelerates the Evolutionary Processes of Cancer

(2012) Steven A. Frank et al.   PLOS BIOLOGY

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

(2011) David J. Mulholland et al.   CANCER CELL

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

The Cancer/Testis Antigen Prostate-associated Gene 4 (PAGE4) Is a Highly Intrinsically Disordered Protein

(2011) Yu Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A majority of the cancer/testis antigens are intrinsically disordered proteins

(2011) Krithika Rajagopalan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protein intrinsic disorder and induced pluripotent stem cells

(2011) Bin Xue et al.   Molecular BioSystems

Intrinsic disorder in the androgen receptor: identification, characterisation and drugability

(2011) Iain J. McEwan   Molecular BioSystems

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Archaic chaos: intrinsically disordered proteins in Archaea

(2010) Bin Xue et al.   BMC Systems Biology

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC

(2010) Alexa B. Turke et al.   CANCER CELL

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

(2010) Jindan Yu et al.   CANCER CELL

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Hub Promiscuity in Protein-Protein Interaction Networks

(2010) Ashwini Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Frequency of Persisters in Escherichia coli Reflects the Kinetics of Awakening from Dormancy

(2010) A. Joers et al.   JOURNAL OF BACTERIOLOGY

Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities

(2010) Dinesh Kumar Singh et al.   Molecular Systems Biology

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

The role of physiological heterogeneity in microbial population behavior

(2010) Mary E Lidstrom et al.   Nature Chemical Biology

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance

(2010) S. Chakrabortee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective behavior in cancer cell populations

(2009) Thomas S. Deisboeck et al.   BIOESSAYS

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Kinetic Advantage of Intrinsically Disordered Proteins in Coupled Folding–Binding Process: A Critical Assessment of the “Fly-Casting” Mechanism

(2009) Yongqi Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Bistability, Epigenetics, and Bet-Hedging in Bacteria

(2008) Jan-Willem Veening et al.   Annual Review of Microbiology

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

(2008) R. Hu et al.   CANCER RESEARCH

Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis

(2008) Jonathan Hickson et al.   CLINICAL & EXPERIMENTAL METASTASIS

The Effect of Diurnal Variation on Clinical Measurement of Serum Testosterone and Other Sex Hormone Levels in Men

(2008) Donald J. Brambilla et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Wild-TypeKRASIs Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer

(2008) Rafael G. Amado et al.   JOURNAL OF CLINICAL ONCOLOGY

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

(2008) M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

(2008) A. A. Cohen et al.   SCIENCE