Dynamic self-reinforcement of gene expression determines acquisition of cellular mechanical memory

Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments

(2021) Brian D. Cosgrove et al.   BIOMATERIALS

Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning

(2021) Adam W. Watson et al.   Cell Reports

Revealing hidden information in osteoblast’s mechanotransduction through analysis of time patterns of critical events

(2020) Gianluca Ascolani et al.   BMC BIOINFORMATICS

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

(2020) Bryant L. Doss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose stem cells exhibit mechanical memory and reduce fibrotic contracture in a rat elbow injury model

(2020) Chelsey Dunham et al.   FASEB JOURNAL

Gone Caving: Roles of the Transcriptional Regulators YAP and TAZ in Skeletal Development

(2020) Christopher D. Kegelman et al.   Current Osteoporosis Reports

miR-21 regulates immunosuppression mediated by myeloid-derived suppressor cells by impairing RUNX1-YAP interaction in lung cancer

(2020) Guangping Meng et al.   Cancer Cell International

Nuclear mechanosensing controls MSC osteogenic potential through HDAC epigenetic remodeling

(2020) Anouk R. Killaars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Materials control of the epigenetics underlying cell plasticity

(2020) Stephanie Nemec et al.   Nature Reviews Materials

Actomyosin and the MRTF-SRF pathway downregulate FGFR1 in mesenchymal stromal cells

(2020) Jip Zonderland et al.   Communications Biology

The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate

(2019) Tasneem Bouzid et al.   Journal of Biological Engineering

Heterogeneity in The Mechanical Properties of Integrins Determines Mechanotransduction Dynamics in Bone Osteoblasts

(2019) Aban Shuaib et al.   Scientific Reports

Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

(2019) Bailey V. Fearing et al.   FASEB JOURNAL

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

(2018) Olivia M. Yu et al.   ONCOGENE

Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export

(2018) Nil Ege et al.   Cell Systems

Interphase human chromosome exhibits out of equilibrium glassy dynamics

(2018) Guang Shi et al.   Nature Communications

Chromatin de-condensation by switching substrate elasticity

(2018) Morgane Rabineau et al.   Scientific Reports

Emergent memory in cell signaling: Persistent adaptive dynamics in cascades can arise from the diversity of relaxation time-scales

(2018) Tanmay Mitra et al.   Scientific Reports

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis

(2017) Yiting Qiao et al.   Cell Reports

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

(2016) Su-Jin Heo et al.   BIOPHYSICAL JOURNAL

MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis

(2016) Tackhoon Kim et al.   EMBO JOURNAL

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

Spatially patterned matrix elasticity directs stem cell fate

(2016) Chun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior

(2015) Conleth A. Mullen et al.   BIOPHYSICAL JOURNAL

Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels

(2015) Rajat K. Das et al.   NATURE MATERIALS

Nuclear deformability and telomere dynamics are regulated by cell geometric constraints

(2015) Ekta Makhija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupled Positive and Negative Feedbacks Produce Diverse Gene Expression Patterns in Colonies

(2015) Namiko Mitarai et al.   mBio

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

Role of Mechanical Cues in Cell Differentiation and Proliferation: A 3D Numerical Model

(2015) Seyed Jamaleddin Mousavi et al.   PLoS One

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

(2015) Su-Jin Heo et al.   Scientific Reports

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Mechanosensitivity and compositional dynamics of cell–matrix adhesions

(2013) Herbert B Schiller et al.   EMBO REPORTS

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Mechanical Activation of Cells Induces Chromatin Remodeling Preceding MKL Nuclear Transport

(2012) K. Venkatesan Iyer et al.   BIOPHYSICAL JOURNAL

Bistability, Bifurcations, and Waddington's Epigenetic Landscape

(2012) James E. Ferrell   CURRENT BIOLOGY

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The molecular and mathematical basis of Waddington's epigenetic landscape: A framework for post-Darwinian biology?

(2011) Sui Huang   BIOESSAYS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

(2011) Michael P. Gantier et al.   NUCLEIC ACIDS RESEARCH

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bistable switches control memory and plasticity in cellular differentiation

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Positive feedback in cellular control systems

(2008) Alexander Y. Mitrophanov et al.   BIOESSAYS

Coherent coupling of feedback loops: a design principle of cell signaling networks

(2008) Yung-Keun Kwon et al.   BIOINFORMATICS

Quantitative analysis of robustness and fragility in biological networks based on feedback dynamics

(2008) Yung-Keun Kwon et al.   BIOINFORMATICS

Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops

(2008) T. Y.-C. Tsai et al.   SCIENCE