Identifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach

A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells

(2020) Shubham Tripathi et al.   PLoS Computational Biology

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

(2019) Cornelia Kröger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Plasticity in Cancer

(2019) Salina Yuan et al.   Cancer Discovery

Dynamics of Phenotypic Heterogeneity during EMT and Stemness in Cancer Progression

(2019) Jolly et al.   Journal of Clinical Medicine

Dynamics of the feedback loops required for the phenotypic stabilization in the epithelial‐mesenchymal transition

(2019) Daner A. Silveira et al.   FEBS Journal

The great escape: tumour cell plasticity in resistance to targeted therapy

(2019) Soufiane Boumahdi et al.   NATURE REVIEWS DRUG DISCOVERY

Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity

(2019) Maria Rita Fumagalli et al.   Cancer Microenvironment

Hybrid epithelial/mesenchymal phenotype(s): The ‘fittest’ for metastasis?

(2018) Mohit Kumar Jolly et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

RACIPE: a computational tool for modeling gene regulatory circuits using randomization

(2018) Bin Huang et al.   BMC Systems Biology

AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation

(2018) Manipa Saha et al.   CANCER RESEARCH

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

Topography of epithelial–mesenchymal plasticity

(2018) Francesc Font-Clos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

(2018) Dongya Jia et al.   Cells

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

(2018) Mohit Kumar Jolly et al.   PHARMACOLOGY & THERAPEUTICS

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Benefits of phenotypic plasticity for population growth in varying environments

(2018) BingKan Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

(2018) Toni Celià-Terrassa et al.   Nature Communications

The GRHL2/ZEB Feedback Loop-A Key Axis in the Regulation of EMT in Breast Cancer

(2017) Steven M. Mooney et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

(2017) Deepika Neelakantan et al.   Nature Communications

Interrogating the topological robustness of gene regulatory circuits by randomization

(2017) Bin Huang et al.   PLoS Computational Biology

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis

(2016) Camille Lehuédé et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Distinctive properties of metastasis-initiating cells

(2016) Toni Celià-Terrassa et al.   GENES & DEVELOPMENT

Stability of the hybrid epithelial/mesenchymal phenotype

(2016) Mohit Kumar Jolly et al.   Oncotarget

The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes

(2015) Shebli Mehrazarin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

OVOL guides the epithelial-hybrid-mesenchymal transition

(2015) Dongya Jia et al.   Oncotarget

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis

(2015) Bin Huang et al.   Scientific Reports

An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

(2015) Tian Hong et al.   PLoS Computational Biology

Network Modeling of TGF  Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation

(2014) S. N. Steinway et al.   CANCER RESEARCH

The architect who never sleeps: Tumor-induced plasticity

(2014) Julia Varga et al.   FEBS LETTERS

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness

(2014) M. K. Jolly et al.   Journal of the Royal Society Interface

The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition

(2014) Bin Huang et al.   Scientific Reports

Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition

(2013) Xiao-Jun Tian et al.   BIOPHYSICAL JOURNAL

Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks

(2013) Regina Samaga et al.   Cell Communication and Signaling

Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

(2013) Hernan Roca et al.   PLoS One

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Logic-based models in systems biology: a predictive and parameter-free network analysis method

(2012) Michelle L. Wynn et al.   Integrative Biology

Coupling between feedback loops in autoregulatory networks affects bistability range, open-loop gain and switching times

(2012) Abhinav Tiwari et al.   PHYSICAL BIOLOGY

Bacterial survival strategies suggest rethinking cancer cooperativity

(2012) Eshel Ben-Jacob et al.   TRENDS IN MICROBIOLOGY

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Understanding gene circuits at cell-fate branch points for rational cell reprogramming

(2010) Joseph X. Zhou et al.   TRENDS IN GENETICS

Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

(2009) Dominik M Wittmann et al.   BMC Systems Biology

BioNumbers—the database of key numbers in molecular and cell biology

(2009) Ron Milo et al.   NUCLEIC ACIDS RESEARCH

Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth

(2008) T. Tsuji et al.   CANCER RESEARCH