Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer
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Title
Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer
Authors
Keywords
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Journal
eLife
Volume 10, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2021-03-17
DOI
10.7554/elife.64522
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Note: Only part of the references are listed.- The Physics of Cellular Decision Making During Epithelial–Mesenchymal Transition
- (2020) Shubham Tripathi et al. Annual Review of Biophysics
- The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells
- (2020) Zhiyuan Hu et al. CANCER CELL
- A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells
- (2020) Shubham Tripathi et al. PLoS Computational Biology
- NEUROD1 is highly expressed in extensive-stage small cell lung cancer and promotes tumor cell migration
- (2020) Yuki Ikematsu et al. LUNG CANCER
- Emergent Properties of the HNF4α-PPARγ Network May Drive Consequent Phenotypic Plasticity in NAFLD
- (2020) Sarthak Sahoo et al. Journal of Clinical Medicine
- The rare YAP1 subtype of Small Cell Lung Cancer revisited in a biobank of 39 Circulating Tumour Cell Patient Derived eXplant models (CDX): A brief report
- (2020) Sarah M. Pearsall et al. Journal of Thoracic Oncology
- Small Cell Lung Cancer from Traditional to Innovative Therapeutics: Building a Comprehensive Network to Optimize Clinical and Translational Research
- (2020) Shanmuga Subbiah et al. Journal of Clinical Medicine
- Identifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach
- (2020) Kishore Hari et al. npj Systems Biology and Applications
- Multi-stability in cellular differentiation enabled by a network of three mutually repressing master regulators
- (2020) Atchuta Srinivas Duddu et al. Journal of the Royal Society Interface
- Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization
- (2020) Marina K. Baine et al. Journal of Thoracic Oncology
- Biological Networks Regulating Cell Fate Choice are Minimally Frustrated
- (2020) Shubham Tripathi et al. PHYSICAL REVIEW LETTERS
- SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures
- (2020) Camille Tlemsani et al. Cell Reports
- Profiling the Non-genetic Origins of Cancer Drug Resistance with a Single-Cell Functional Genomics Approach Using Predictive Cell Dynamics
- (2020) Mickael Meyer et al. Cell Systems
- A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer
- (2020) Atish Mohanty et al. iScience
- Defining the Hallmarks of Metastasis
- (2019) Danny R. Welch et al. CANCER RESEARCH
- Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance
- (2019) Yapeng Su et al. PLoS Computational Biology
- Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations
- (2019) Catherine R Armbruster et al. eLife
- Metabolic constraints drive self-organization of specialized cell groups
- (2019) Sriram Varahan et al. eLife
- Dynamics of Phenotypic Heterogeneity during EMT and Stemness in Cancer Progression
- (2019) Jolly et al. Journal of Clinical Medicine
- Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors
- (2019) Anchal Sharma et al. Cell Reports
- Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
- (2019) David J. Wooten et al. PLoS Computational Biology
- YAP1 promotes multidrug resistance of small cell lung cancer by CD74‐related signaling pathways
- (2019) Yongchun Song et al. Cancer Medicine
- POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer
- (2018) Yu-Han Huang et al. GENES & DEVELOPMENT
- Predicting perturbation patterns from the topology of biological networks
- (2018) Marc Santolini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Topography of epithelial–mesenchymal plasticity
- (2018) Francesc Font-Clos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modeling small cell lung cancer (SCLC) biology through deterministic and stochastic mathematical models
- (2018) Ravi Salgia et al. Oncotarget
- Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity
- (2018) Mohit Kumar Jolly et al. Frontiers in Oncology
- Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death
- (2018) Haruko Miura et al. Cell Reports
- Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments
- (2017) Coco van Boxtel et al. Journal of the Royal Society Interface
- Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
- (2017) Sydney M. Shaffer et al. NATURE
- Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer
- (2017) Karen McColl et al. Oncotarget
- Phenotypic heterogeneity promotes adaptive evolution
- (2017) Zoltán Bódi et al. PLOS BIOLOGY
- Interrogating the topological robustness of gene regulatory circuits by randomization
- (2017) Bin Huang et al. PLoS Computational Biology
- Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity
- (2016) Akshata R. Udyavar et al. CANCER RESEARCH
- Loss ofYAP1defines neuroendocrine differentiation of lung tumors
- (2016) Takeshi Ito et al. CANCER SCIENCE
- Distinctive properties of metastasis-initiating cells
- (2016) Toni Celià-Terrassa et al. GENES & DEVELOPMENT
- Core signalling motif displaying multistability through multi-state enzymes
- (2016) Song Feng et al. Journal of the Royal Society Interface
- Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2
- (2016) Jason A. Somarelli et al. MOLECULAR AND CELLULAR BIOLOGY
- Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
- (2016) Michael Ramirez et al. Nature Communications
- ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs
- (2016) Mark D. Borromeo et al. Cell Reports
- Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer
- (2015) Kosuke Fujino et al. AMERICAN JOURNAL OF PATHOLOGY
- Phenotypic Heterogeneity, a Phenomenon That May Explain Why Quorum Sensing Does Not Always Result in Truly Homogenous Cell Behavior
- (2015) Jessica Grote et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Comprehensive genomic profiles of small cell lung cancer
- (2015) Julie George et al. NATURE
- A functional perspective on phenotypic heterogeneity in microorganisms
- (2015) Martin Ackermann NATURE REVIEWS MICROBIOLOGY
- Operating principles of Notch–Delta–Jagged module of cell–cell communication
- (2015) Mohit Kumar Jolly et al. NEW JOURNAL OF PHYSICS
- DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2
- (2015) J T Poirier et al. ONCOGENE
- The differential view of genotype–phenotype relationships
- (2015) Virginie Orgogozo et al. Frontiers in Genetics
- Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions
- (2014) J. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tristability in Cancer-Associated MicroRNA-TF Chimera Toggle Switch
- (2013) Mingyang Lu et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Selective Tropism of Seneca Valley Virus for Variant Subtype Small Cell Lung Cancer
- (2013) J. T. Poirier et al. JNCI-Journal of the National Cancer Institute
- NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM
- (2013) J. K. Osborne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-Darwinian dynamics in therapy-induced cancer drug resistance
- (2013) Angela Oliveira Pisco et al. Nature Communications
- Bacterial survival strategies suggest rethinking cancer cooperativity
- (2012) Eshel Ben-Jacob et al. TRENDS IN MICROBIOLOGY
- A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer
- (2011) Joaquim Calbo et al. CANCER CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Motifs emerge from function in model gene regulatory networks
- (2011) Z. Burda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
- (2010) Sreenath V. Sharma et al. CELL
- Understanding gene circuits at cell-fate branch points for rational cell reprogramming
- (2010) Joseph X. Zhou et al. TRENDS IN GENETICS
- Large-Scale Analysis of Network Bistability for Human Cancers
- (2010) Tetsuya Shiraishi et al. PLoS Computational Biology
- Achaete-Scute Complex Homologue 1 Regulates Tumor-Initiating Capacity in Human Small Cell Lung Cancer
- (2009) T. Jiang et al. CANCER RESEARCH
- Defining Network Topologies that Can Achieve Biochemical Adaptation
- (2009) Wenzhe Ma et al. CELL
- Non-genetic heterogeneity of cells in development: more than just noise
- (2009) S. Huang DEVELOPMENT
- Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
- (2009) Sabrina L. Spencer et al. NATURE
- Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours
- (2009) Amy Brock et al. NATURE REVIEWS GENETICS
- Multistable Decision Switches for Flexible Control of Epigenetic Differentiation
- (2008) Raúl Guantes et al. PLoS Computational Biology
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