Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases

OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis

(2023) Shin-Ae Lee et al.   NATURE CELL BIOLOGY

RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8

(2023) Takayuki Imanishi et al.   Science Advances

GPR109A controls neutrophil extracellular traps formation and improve early sepsis by regulating ROS/PAD4/Cit-H3 signal axis

(2023) Wenjin Guo et al.   Experimental Hematology & Oncology

Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism

(2023) Deyu Huang et al.   Experimental Hematology & Oncology

Sublethal necroptosis signaling promotes inflammation and liver cancer

(2023) Mihael Vucur et al.   IMMUNITY

GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation

(2023) Marco De Giovanni et al.   IMMUNOLOGICAL REVIEWS

EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis

(2023) Huiling Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury

(2023) Jingjing Guo et al.   Journal of Agricultural and Food Chemistry

Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway

(2023) Xinqi Zhang et al.   Journal of Medicinal Chemistry

TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury

(2023) Wen-Jing Zhong et al.   Journal of Translational Medicine

Analysis of necroptosis-related prognostic genes and immune infiltration in idiopathic pulmonary fibrosis

(2023) Hongzuo Chen et al.   Frontiers in Immunology

Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment

(2023) Thi Oanh Bui et al.   Experimental Hematology & Oncology

Complement-related molecular classification and a gene signature for lung adenocarcinoma

(2023) Lin Zhang et al.   Experimental Hematology & Oncology

Outcome differences between PD-1/PD-L1 inhibitors-based monotherapy and combination treatments in NSCLC with brain metastases

(2023) Haowei Wang et al.   Experimental Hematology & Oncology

Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy

(2023) Yong Xi et al.   IMMUNOLOGICAL REVIEWS

SARS‐CoV‐2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction

(2023) Siyuan Hao et al.   JOURNAL OF MEDICAL VIROLOGY

The therapeutic potential of targeting regulated non-apoptotic cell death

(2023) Kamyar Hadian et al.   NATURE REVIEWS DRUG DISCOVERY

Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion

(2023) Qi Liu et al.   Particle and Fibre Toxicology

PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation

(2023) Juan Du et al.   Cell Death & Disease

Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia

(2022) Xiaoming Li et al.   CELL DEATH AND DIFFERENTIATION

Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation

(2022) Yi Li et al.   Cell Reports

Interferon-γ Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL

(2022) Qin Hao et al.   Cells

Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development

(2022) Ming Li et al.   CELL DEATH AND DIFFERENTIATION

L‐OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice

(2022) Hui‐Ling Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A non-canonical tricarboxylic acid cycle underlies cellular identity

(2022) Paige K. Arnold et al.   NATURE

Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis

(2022) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model

(2022) Yan-Ru Cui et al.   PHYTOMEDICINE

Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury

(2022) Wenjun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease

(2022) Anna Guyatt et al.   THORAX

Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury

(2022) Dongxuan Huang et al.   Cell Death & Disease

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

(2022) Yasmine Messaoud-Nacer et al.   Cell Death & Disease

MLKL Regulates Rapid Cell Death-independent HMGB1 Release in RSV Infected Airway Epithelial Cells

(2022) Jennifer Simpson et al.   Frontiers in Cell and Developmental Biology

Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis

(2022) Jinping Wang et al.   Cell Death Discovery

Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma

(2022) Andong He et al.   ALLERGY

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

(2022) Chi G. Weindel et al.   CELL

Living without eosinophils: evidence from mouse and man

(2022) David J. Jackson et al.   EUROPEAN RESPIRATORY JOURNAL

The web of death: the expanding complexity of necroptotic signaling

(2022) Christopher R. Horne et al.   TRENDS IN CELL BIOLOGY

Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

(2022) Ethan Iverson et al.   mBio

Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study

(2022) Tessa M Kole et al.   Lancet Respiratory Medicine

Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation

(2022) Ziyi Guo et al.   Science Advances

Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell

(2022) Ting Gong et al.   Communications Biology

Staphylococcal superantigen-like protein 10 induces necroptosis through TNFR1 activation of RIPK3-dependent signal pathways

(2022) Nan Jia et al.   Communications Biology

Modified dendritic cell-derived exosomes activate both NK cells and T cells through the NKG2D/NKG2D-L pathway to kill CML cells with or without T315I mutation

(2022) Zhuanyun Du et al.   Experimental Hematology & Oncology

PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis

(2022) Feng Liu et al.   JACC-Basic to Translational Science

IL1RAP expression and the enrichment of IL ‐33 activation signatures in severe neutrophilic asthma

(2022) Yusef Eamon Badi et al.   ALLERGY

The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia

(2022) John D Lyons et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia promotes osteogenesis by facilitating acetyl‐CoA ‐mediated mitochondrial–nuclear communication

(2022) Andromachi Pouikli et al.   EMBO JOURNAL

Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis

(2022) Diego A. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrostatin-1 Alleviates Lung Ischemia-Reperfusion Injury via Inhibiting Necroptosis and Apoptosis of Lung Epithelial Cells

(2022) Lingjun Dong et al.   Cells

Impaired mitochondria of Tregs decreases OXPHOS-derived ATP in primary immune thrombocytopenia with positive plasma pathogens detected by metagenomic sequencing

(2022) Yanxia Zhan et al.   Experimental Hematology & Oncology

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

(2022) Hannelore P. Van Eeckhoutte et al.   EUROPEAN RESPIRATORY JOURNAL

Receptor‐interacting protein 3‐phosphorylated Ca 2+ /calmodulin‐dependent protein kinase II and mixed lineage kinase domain‐like protein mediate intracerebral hemorrhage‐induced neuronal necroptosis

(2022) Guiqiang Yuan et al.   JOURNAL OF NEUROCHEMISTRY

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

(2022) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis

(2022) Zhiyong Zhang et al.   Experimental Hematology & Oncology

The role of neutrophil extracellular traps in cancer progression, metastasis and therapy

(2022) Yue Chen et al.   Experimental Hematology & Oncology

Necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitate Pseudomonas aeruginosa mediated lung injury

(2022) Haoyang Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during Respiratory Syncytial Virus infection

(2021) Leonardo Duarte Santos et al.   EUROPEAN RESPIRATORY JOURNAL

Protective effect of necrosulfonamide on rat pulmonary ischemia-reperfusion injury via inhibition of necroptosis

(2021) Satoshi Ueda et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

RIPK3 Activates MLKL-Mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection

(2021) Hua-Rong Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epithelium- and endothelium-derived exosomes regulate the alveolar macrophages by targeting RGS1 mediated calcium signaling-dependent immune response

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Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration

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Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury

(2021) Derek C. Liberti et al.   Cell Reports

Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease

(2021) Zhe Lu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Saga of Necroptosis in Chronic Obstructive Pulmonary Disease Continues

(2021) Alexandra C. Racanelli et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis

(2021) Heather Koehler et al.   Cell Host & Microbe

Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation

(2021) Nikos Oikonomou et al.   Mucosal Immunology

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

(2021) Jerzy A. Woznicki et al.   Cell Death & Disease

Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma

(2021) Yoshihiko Raita et al.   Nature Communications

Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza

(2021) Sang-Sang Park et al.   Cell Reports

RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease

(2021) Dongshi Chen et al.   JCI Insight

Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma

(2021) Rhiannon B. Werder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis

(2021) Zikou Liu et al.   EMBO JOURNAL

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death

(2021) Rosalind L. Ang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dying cells fan the flames of inflammation

(2021) Kim Newton et al.   SCIENCE

Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice

(2021) Huihui Tao et al.   TOXICOLOGY LETTERS

SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer

(2021) Ying Yang et al.   Cell Death & Disease

Generation of Alveolar Epithelium Using Reconstituted Basement Membrane and hiPSC‐Derived Organoids

(2021) Yong He et al.   Advanced Healthcare Materials

RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells

(2020) Jennifer Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome

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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis

(2020) Hui Chen et al.   CELL DEATH AND DIFFERENTIATION

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

(2020) Bart Tummers et al.   IMMUNITY

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necroptosis Mediates Cigarette Smoke-Induced Inflammatory Responses in Macrophages

(2020) Yong Wang et al.   International Journal of Chronic Obstructive Pulmonary Disease

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

(2020) Yongxing Lai et al.   Redox Biology

Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of TCM formulae

(2020) Zihe Ding et al.   PHARMACOLOGICAL RESEARCH

Integration of innate immune signaling by caspase-8 cleavage of N4BP1

(2020) Alexander D. Gitlin et al.   NATURE

STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

(2020) Andrew J. Paris et al.   NATURE CELL BIOLOGY

TBK1/IKKε Negatively Regulate LPS-Induced Neutrophil Necroptosis and Lung Inflammation

(2020) Jieyan Wang et al.   SHOCK

Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis

(2020) Lori Bedient et al.   Viruses-Basel

Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death

(2020) Se-Yeon Park et al.   Cell Death & Disease

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis

(2020) Norberto Gonzalez-Juarbe et al.   Cell Reports

Extracellular vesicle-cargo miR-185-5p reflects type II alveolar cell death after oxidative stress

(2020) Jonathan M. Carnino et al.   Cell Death Discovery

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis

(2020) Martin Rübbelke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway

(2019) Huojun Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling

(2019) Simone Füllsack et al.   Cell Death & Disease

Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells

(2019) Huojun Zhang et al.   LIFE SCIENCES

Prolonged Cold-Ischemia Induces Necroptotic Cell Death in Ischemia Reperfusion Injury and Contributes to Primary Graft Dysfunction After Lung Transplantation.

(2019) Xingan Wang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

In utero tobacco smoke exposure alters lung inflammation, viral clearance and CD8+ T cell responses in neonatal mice infected with respiratory syncytial virus

(2019) Nagarjuna Reddy Cheemarla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation

(2019) Chaohuan Guo et al.   JOURNAL OF AUTOIMMUNITY

Osteopontin mediates necroptosis in lung injury after transplantation of ischaemic renal allografts in rats

(2019) Hailin Zhao et al.   BRITISH JOURNAL OF ANAESTHESIA

Peripheral circulating exosomes-mediated delivery of miR-155 as a novel mechanism for acute lung inflammation

(2019) Kangfeng Jiang et al.   MOLECULAR THERAPY

Necrosis Rather Than Apoptosis is The Dominant form of Alveolar Epithelial Cell Death In Lipopolysaccharide-Induced Experimental Acute Respiratory Distress Syndrome Model

(2019) Nao Tamada et al.   SHOCK

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Respiratory syncytial virus (RSV): a scourge from infancy to old age

(2019) James Andrew Coultas et al.   THORAX

A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis

(2019) Akio Takezaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1

(2019) Xue-ke Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients

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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

(2019) Mary Speir et al.   NATURE IMMUNOLOGY

Involvement of Alveolar Epithelial Cell Necroptosis in IPF Pathogenesis.

(2018) Ji-Min Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

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Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1–mediated ischemia-reperfusion injury after lung transplantation

(2018) Takashi Kanou et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

MTOR Suppresses Cigarette Smoke–Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease

(2018) Yong Wang et al.   JOURNAL OF IMMUNOLOGY

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

(2018) Alessandro Annibaldi et al.   MOLECULAR CELL

TWEAK and RIPK1 mediate a second wave of cell death during AKI

(2018) Diego Martin-Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis

(2018) Alexandra C. Bolognese et al.   SURGERY

Inhibiting PSMα-induced neutrophil necroptosis protects mice with MRSA pneumonia by blocking the agr system

(2018) Ying Zhou et al.   Cell Death & Disease

RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

(2018) Jingxian Chen et al.   Journal of Translational Medicine

NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function

(2018) Laxman Ghimire et al.   PLoS Pathogens

Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice

(2018) Hern-Tze Tina Tan et al.   ALLERGY

Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model

(2018) Inbar Shlomovitz et al.   FEBS Journal

IFN-γ and IL-17A differentially influence the response of human macrophages and neutrophils to Pseudomonas aeruginosa infection.

(2018) Sirina Muntaka et al.   INFECTION AND IMMUNITY

NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during Gram-positive pneumonia

(2018) Sagar Paudel et al.   Mucosal Immunology

Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300

(2018) Takahito Otani et al.   Cell Death & Disease

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

(2017) Yangchun Xie et al.   GASTROENTEROLOGY

High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)

(2017) Christophe Milési et al.   INTENSIVE CARE MEDICINE

RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

(2017) Yi Qu et al.   Cell Death & Disease

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tissue damage negatively regulates LPS-induced macrophage necroptosis

(2016) Z Li et al.   CELL DEATH AND DIFFERENTIATION

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

(2016) Diana Legarda et al.   Cell Reports

Influenza virus-induced lung injury: pathogenesis and implications for treatment

(2015) Susanne Herold et al.   EUROPEAN RESPIRATORY JOURNAL

The innate immune function of airway epithelial cells in inflammatory lung disease

(2015) Pieter S. Hiemstra et al.   EUROPEAN RESPIRATORY JOURNAL

Necroptosis and parthanatos are involved in remote lung injury after receiving ischemic renal allografts in rats

(2015) Hailin Zhao et al.   KIDNEY INTERNATIONAL

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

(2015) Norberto González-Juarbe et al.   PLoS Pathogens

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

(2015) Kipyegon Kitur et al.   PLoS Pathogens

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo

(2015) R. Takemura et al.   Cancer Immunology Research

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells

(2014) Haiying Sun et al.   ACS Chemical Biology

Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation

(2014) Danielle Y. Qing et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MUC1 Regulates Epithelial Inflammation and Apoptosis by PolyI:C through Inhibition of Toll/IL-1 Receptor-Domain–Containing Adapter-Inducing IFN-β (TRIF) Recruitment to Toll-like Receptor 3

(2014) Kosuke Kato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

SnapShot: Necroptosis

(2014) Wen Zhou et al.   CELL

Toll-like Receptor-mediated Down-regulation of the Deubiquitinase Cylindromatosis (CYLD) Protects Macrophages from Necroptosis in Wild-derived Mice

(2014) Stephen A. Schworer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages

(2014) S. McComb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

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Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

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Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

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Activation of Parenchymal CD47 Promotes Renal Ischemia-Reperfusion Injury

(2012) N. M. Rogers et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

The Pathophysiology of Endothelin in Complications After Solid Organ Transplantation

(2012) Amresh Raina et al.   TRANSPLANTATION

Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis

(2012) Eun-Woo Lee et al.   Nature Communications

Eosinophils: multifaceted biological properties and roles in health and disease

(2011) Hirohito Kita   IMMUNOLOGICAL REVIEWS

Bivalent Smac Mimetics with a Diazabicyclic Core as Highly Potent Antagonists of XIAP and cIAP1/2 and Novel Anticancer Agents

(2011) Yuefeng Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

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