Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300

Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet

(2016) Yu Yasutake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration

(2016) Akiko Mizokami et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Maternal oral administration of osteocalcin protects offspring from metabolic impairment in adulthood

(2016) Tomoyo Kawakubo-Yasukochi et al.   Obesity

Signaling pathway for adiponectin expression in adipocytes by osteocalcin

(2015) Takahito Otani et al.   CELLULAR SIGNALLING

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion

(2014) Akiko Mizokami et al.   BONE

MLKL regulates necrotic plasma membrane permeabilization

(2014) Lorenzo Galluzzi et al.   CELL RESEARCH

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions

(2013) Franck Oury et al.   CELL

Control ofFoxo1Gene Expression by Co-activator P300

(2013) Anne R. Wondisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis

(2013) Franck Oury et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice

(2013) Akiko Mizokami et al.   PLoS One

The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358in adipocytes

(2012) Emma Henriksson et al.   BIOCHEMICAL JOURNAL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor Is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells

(2012) Manami Oya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice

(2011) Mathieu Ferron et al.   BONE

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

(2011) Min Pi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes

(2009) Partha Chakrabarti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice

(2008) Mathieu Ferron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA