Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury

Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies

(2020) Rebecca Windmueller et al.   Cell Reports

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

(2020) Maria C. Basil et al.   Cell Stem Cell

Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

(2020) Jinwook Choi et al.   Cell Stem Cell

Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration

(2020) Konstantinos-Dionysios Alysandratos et al.   Annual Review of Physiology

Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction

(2020) Hiroaki Katsura et al.   Cell Stem Cell

STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

(2020) Andrew J. Paris et al.   NATURE CELL BIOLOGY

Basal-like Progenitor Cells: A Review of Dysplastic Alveolar Regeneration and Remodeling in Lung Repair

(2020) Maria Fernanda de Mello Costa et al.   Stem Cell Reports

IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration

(2019) Hiroaki Katsura et al.   Stem Cell Reports

Early lineage specification defines alveolar epithelial ontogeny in the murine lung

(2019) David B. Frank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury

(2019) Tingting Yuan et al.   Stem Cell Reports

Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate

(2019) Derek C. Liberti et al.   DEVELOPMENTAL BIOLOGY

Cellular crosstalk in the development and regeneration of the respiratory system

(2019) Jarod A. Zepp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vitro expansion of endogenous human alveolar epithelial type II cells in fibroblast-free spheroid culture

(2019) Kazushige Shiraishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells

(2019) Munemasa Mori et al.   NATURE MEDICINE

FGFR2 is Required for AEC2 Homeostasis and Survival Following Bleomycin-Induced Lung Injury

(2019) Samuel J Dorry et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells

(2018) Jiao Li et al.   DEVELOPMENTAL CELL

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

(2018) William J. Zacharias et al.   NATURE

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

Building and Regenerating the Lung Cell by Cell

(2018) Jeffrey A. Whitsett et al.   PHYSIOLOGICAL REVIEWS

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

(2017) Ying Xi et al.   NATURE CELL BIOLOGY

Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection

(2017) Nikolaos M. Nikolaidis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation

(2016) Yi Wang et al.   DEVELOPMENTAL CELL

Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation

(2016) David B. Frank et al.   Cell Reports

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair

(2016) Jennifer Quantius et al.   PLoS Pathogens

Rare SOX2 + Airway Progenitor Cells Generate KRT5 + Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection

(2016) Samriddha Ray et al.   Stem Cell Reports

Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair

(2015) BreAnne MacKenzie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The development and plasticity of alveolar type 1 cells

(2015) Jun Yang et al.   DEVELOPMENT

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

(2015) Tien Peng et al.   NATURE

p63+Krt5+ distal airway stem cells are essential for lung regeneration

(2014) Wei Zuo et al.   NATURE

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

(2014) Andrew E. Vaughan et al.   NATURE

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

Lung epithelial branching program antagonizes alveolar differentiation

(2013) D. R. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

(2012) Panteleimon Rompolas et al.   NATURE

Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection

(2011) Pooja A. Kumar et al.   CELL

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice

(2011) Harold A. Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of Fibroblast Growth Factor-10 during Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice

(2009) Varsha V. Gupte et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Conditional gene inactivation reveals roles forFgf10andFgfr2in establishing a normal pattern of epithelial branching in the mouse lung

(2009) Lisa L. Abler et al.   DEVELOPMENTAL DYNAMICS

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE