Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

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TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

(2020) Lili Wang et al.   Frontiers in Cell and Developmental Biology

GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition

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Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

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RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)

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Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis

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Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

(2019) Lingbin Sun et al.   Cell Death & Disease

Influenza Virus Infection Induces ZBP1 Expression and Necroptosis in Mouse Lungs

(2019) Yun Wang et al.   Frontiers in Cellular and Infection Microbiology

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis

(2018) Xingfeng Qiu et al.   CELL DEATH AND DIFFERENTIATION

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

RIP kinases as modulators of inflammation and immunity

(2018) Sudan He et al.   NATURE IMMUNOLOGY

Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation

(2018) Stéfanie P. Muraro et al.   Scientific Reports

Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis

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Methodology of drug screening and target identification for new necroptosis inhibitors

(2018) Pengchao Pan et al.   Journal of Pharmaceutical Analysis

Inflammasome antagonism by human parainfluenza virus type 3 C protein

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Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment

(2016) Cameron Griffiths et al.   CLINICAL MICROBIOLOGY REVIEWS

Alveolar Macrophages Can Control Respiratory Syncytial Virus Infection in the Absence of Type I Interferons

(2016) Spyridon Makris et al.   Journal of Innate Immunity

Respiratory Syncytial Virus Infection Triggers Epithelial HMGB1 Release as a Damage-Associated Molecular Pattern Promoting a Monocytic Inflammatory Response

(2016) Yashoda M. Hosakote et al.   JOURNAL OF VIROLOGY

Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations

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Autophagy, TGF-β, and SMAD-2/3 Signaling Regulates Interferon-β Response in Respiratory Syncytial Virus Infected Macrophages

(2016) Swechha M. Pokharel et al.   Frontiers in Cellular and Infection Microbiology

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining

(2015) Sabine Pietkiewicz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Regulation of TLR3 Activation by S100A9

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Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death

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Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

(2015) Kipyegon Kitur et al.   PLoS Pathogens

Die another way – non-apoptotic mechanisms of cell death

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Nedd8 Regulates Inflammasome-Dependent Caspase-1 Activation

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Respiratory Syncytial Virus Infection and Bronchiolitis

(2014) Giovanni Piedimonte et al.   PEDIATRICS IN REVIEW

Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes

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DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

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Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

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Respiratory Syncytial Virus Infection: Mechanisms of Redox Control and Novel Therapeutic Opportunities

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TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection

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Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

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A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis

(2012) Anne L. Hotard et al.   VIROLOGY

Viral-mediated Inhibition of Antioxidant Enzymes Contributes to the Pathogenesis of Severe Respiratory Syncytial Virus Bronchiolitis

(2011) Yashoda M. Hosakote et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Respiratory syncytial virus vaccine development

(2011) Julia L Hurwitz   Expert Review of Vaccines

Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens

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Viral pneumonia

(2011) Olli Ruuskanen et al.   LANCET

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway

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Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4- and IFN-β-dependent

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Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

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Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2

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