SARS‐CoV‐2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction

Programmed cell death: the pathways to severe COVID-19?

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ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

(2022) Rajendra Karki et al.   Science Immunology

Pathway of Cell Death and Its Role in Virus Infection

(2022) Xiaoxue Chen et al.   VIRAL IMMUNOLOGY

Assessing the impact of SARS-CoV-2 infection on the dynamics of dengue and HIV via fractional derivatives

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SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

(2021) André C. Ferreira et al.   Cell Death Discovery

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity

(2021) Nan Qin et al.   Frontiers of Medicine

TRIM25 Rescues Against Doxorubicin-Induced Pyroptosis Through Promoting NLRP1 Ubiquitination

(2021) Xiaxia Wang et al.   Cardiovascular Toxicology

Viral Suppression of RIPK1-Mediated Signaling

(2021) Darshika J. Udawatte et al.   mBio

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity

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SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

(2021) Gang Xu et al.   CELL RESEARCH

TAF1 inhibitor Bay-299 induces cell death in acute myeloid leukemia

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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

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(2020) Nanshan Chen et al.   LANCET

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(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19

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(2020) Dongwan Kim et al.   CELL

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(2020) Xuping Xie et al.   Cell Host & Microbe

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Symptom Screening at Illness Onset of Health Care Personnel With SARS-CoV-2 Infection in King County, Washington

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(2020) Roman Wölfel et al.   NATURE

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Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility — King County, Washington, March 2020

(2020) Anne Kimball et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Coronavirus Disease 2019–COVID-19

(2020) Kuldeep Dhama et al.   CLINICAL MICROBIOLOGY REVIEWS

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

(2020) Abigail Vanderheiden et al.   JOURNAL OF VIROLOGY

Estimates of the severity of coronavirus disease 2019: a model-based analysis

(2020) Robert Verity et al.   LANCET INFECTIOUS DISEASES

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

(2020) Lauren Mifflin et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

(2020) Mayla Gabriela Silva Borba et al.   JAMA Network Open

25 years of research put RIPK1 in the clinic

(2020) Lin Liu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis

(2020) Lori Bedient et al.   Viruses-Basel

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

(2020) Nikita V. Ivanisenko et al.   Cell Death Discovery

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Primidone blocks RIPK1-driven cell death and inflammation

(2020) Theresa Riebeling et al.   CELL DEATH AND DIFFERENTIATION

Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians

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PANoptosis in microbial infection

(2020) David E Place et al.   CURRENT OPINION IN MICROBIOLOGY

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Collateral Damage: Necroptosis in the Development of Lung Injury

(2019) Hilary Faust et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

(2018) Teneema Kuriakose et al.   TRENDS IN IMMUNOLOGY

Necroptosis in anti-viral inflammation

(2018) Himani Nailwal et al.   CELL DEATH AND DIFFERENTIATION

RIPK1–RIPK3–MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils

(2018) Laiana A. Barbosa et al.   Frontiers in Immunology

Cell Death in the Lung: The Apoptosis–Necroptosis Axis

(2018) Maor Sauler et al.   Annual Review of Physiology

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Hydrogen peroxide induces programmed necrosis in rat nucleus pulposus cells through the RIP1/RIP3-PARP-AIF pathway

(2017) Lei Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis

(2017) Xuefeng Deng et al.   JOURNAL OF VIROLOGY

Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection

(2017) Megan H. Orzalli et al.   TRENDS IN CELL BIOLOGY

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Cilia and Mucociliary Clearance

(2016) Ximena M. Bustamante-Marin et al.   Cold Spring Harbor Perspectives in Biology

Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection

(2015) Keith Meyer et al.   Scientific Reports

Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44+/CD24-) in MCF-7 by Upregulating Mucin1 and EpCAM

(2015) Na Zhou et al.   Journal of Cancer

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF- B Activation via the DNA-Dependent Activator of IFN Regulatory Factors

(2014) W. J. Kaiser et al.   JOURNAL OF IMMUNOLOGY

Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection

(2014) Junqi Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pneumocystis jirovecii Can Be Productively Cultured in Differentiated CuFi-8 Airway Cells

(2014) V. Schildgen et al.   mBio

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo

(2012) R. Villenave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia

(2012) Qinfeng Huang et al.   PLoS Pathogens

The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

(2011) M. Vareille et al.   CLINICAL MICROBIOLOGY REVIEWS

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Cyclophilin A release as a biomarker of necrotic cell death

(2010) D E Christofferson et al.   CELL DEATH AND DIFFERENTIATION

The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS): An up-to-date cell-specific review

(2010) Vasiliki Galani et al.   PATHOLOGY RESEARCH AND PRACTICE

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

The Capsid Proteins of Aleutian Mink Disease Virus Activate Caspases and Are Specifically Cleaved during Infection

(2009) F. Cheng et al.   JOURNAL OF VIROLOGY