Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

Investigating the lytic activity and structural properties of Staphylococcus aureus phenol soluble modulin (PSM) peptide toxins

(2014) Maisem Laabei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Thepsmα Locus Regulates Production of Staphylococcus aureus Alpha-Toxin during Infection

(2014) Bryan J. Berube et al.   INFECTION AND IMMUNITY

Phagocytosis of Staphylococcus aureus by Human Neutrophils Prevents Macrophage Efferocytosis and Induces Programmed Necrosis

(2014) M. C. Greenlee-Wacker et al.   JOURNAL OF IMMUNOLOGY

The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus

(2014) Francis Alonzo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Two Faces of Receptor Interacting Protein Kinase-1

(2014) Ricardo Weinlich et al.   MOLECULAR CELL

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Plug Release Mechanism for Membrane Permeation by MLKL

(2014) Lijing Su et al.   STRUCTURE

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

Igniting the Fire: Staphylococcus aureus Virulence Factors in the Pathogenesis of Sepsis

(2014) Michael E. Powers et al.   PLoS Pathogens

Induction of Type I Interferon Signaling Determines the Relative Pathogenicity of Staphylococcus aureus Strains

(2014) Dane Parker et al.   PLoS Pathogens

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia

(2013) Sun-Mi Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza A Exacerbates Staphylococcus aureus Pneumonia by Attenuating IL-1  Production in Mice

(2013) K. M. Robinson et al.   JOURNAL OF IMMUNOLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Essential Staphylococcus aureus toxin export system

(2013) Som S Chatterjee et al.   NATURE MEDICINE

Phenol-soluble modulins and staphylococcal infection

(2013) Andreas Peschel et al.   NATURE REVIEWS MICROBIOLOGY

Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1

(2013) A. L. DuMont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids

(2013) Ashley L. DuMont et al.   TRENDS IN MICROBIOLOGY

Emergence of the Epidemic Methicillin-Resistant Staphylococcus aureus Strain USA300 Coincides with Horizontal Transfer of the Arginine Catabolic Mobile Element and speG-mediated Adaptations for Survival on Skin

(2013) P. J. Planet et al.   mBio

Bacterial Pathogens Activate a Common Inflammatory Pathway through IFNλ Regulation of PDCD4

(2013) Taylor S. Cohen et al.   PLoS Pathogens

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Staphylococcus aureus Induces Type I IFN Signaling in Dendritic Cells Via TLR9

(2012) D. Parker et al.   JOURNAL OF IMMUNOLOGY

Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

(2012) Chahnaz Kebaier et al.   JOURNAL OF INFECTIOUS DISEASES

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Staphylococcus aureus Hemolysins, bi-component Leukocidins, and Cytolytic Peptides: A Redundant Arsenal of Membrane-Damaging Virulence Factors?

(2012) François Vandenesch et al.   Frontiers in Cellular and Infection Microbiology

Participation of CD11c+Leukocytes in Methicillin-Resistant Staphylococcus aureus Clearance from the Lung

(2011) Francis J. Martin et al.   INFECTION AND IMMUNITY

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice

(2011) Ichiro Inoshima et al.   NATURE MEDICINE

Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

(2010) M. Z. David et al.   CLINICAL MICROBIOLOGY REVIEWS

Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia

(2010) Ronan Kapetanovic et al.   MICROBES AND INFECTION

Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis

(2010) Ashley L. DuMont et al.   MOLECULAR MICROBIOLOGY

Identification of a Novel Staphylococcus aureus Two-Component Leukotoxin Using Cell Surface Proteomics

(2010) Christy L. Ventura et al.   PLoS One

Waves of resistance: Staphylococcus aureus in the antibiotic era

(2009) Henry F. Chambers et al.   NATURE REVIEWS MICROBIOLOGY

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia

(2008) Helen M. Marriott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY