GPR109A controls neutrophil extracellular traps formation and improve early sepsis by regulating ROS/PAD4/Cit-H3 signal axis

The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps

(2021) Falko Apel et al.   Science Signaling

Synthetic hydrogel nanoparticles for sepsis therapy

(2021) Hiroyuki Koide et al.   Nature Communications

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

(2021) Andrew J. Monteith et al.   Science Advances

Netting Gut Disease: Neutrophil Extracellular Trap in Intestinal Pathology

(2021) Kai Chen et al.   Oxidative Medicine and Cellular Longevity

De-escalation antibiotic therapy alleviates organ injury through modulation of NETs formation during sepsis

(2021) Zehua Duan et al.   Cell Death Discovery

Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps

(2020) Mototsugu Tanaka et al.   Scientific Reports

Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury

(2020) Kumar Vaibhav et al.   Science Advances

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility

(2020) Laura M. Wingler et al.   TRENDS IN CELL BIOLOGY

Neonatal sepsis: within and beyond China

(2020) Ying Dong et al.   CHINESE MEDICAL JOURNAL

The vitals of NETs

(2020) Chuyi Tan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Blood coagulation: a powerful bactericidal mechanism of human innate immunity

(2019) Hayk Minasyan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

(2019) Dorian A. Rosen et al.   Science Translational Medicine

Sepsis and septic shock: current approaches to management

(2019) Kelly Thompson et al.   INTERNAL MEDICINE JOURNAL

Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines

(2019) Marco Antonio Cassatella et al.   TRENDS IN IMMUNOLOGY

NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization

(2019) Chao Song et al.   EXPERIMENTAL CELL RESEARCH

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms

(2019) Raphael J. F. Felizardo et al.   FASEB JOURNAL

Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis

(2019) Nina Droz et al.   Antimicrobial Resistance and Infection Control

Enhancing Recovery From Sepsis

(2018) Hallie C. Prescott et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

(2018) Akshay A. D’Cruz et al.   Science Signaling

G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis

(2018) Guangxin Chen et al.   Frontiers in Immunology

Neutrophil dysregulation during sepsis: an overview and update

(2017) Xiao-Fei Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

NET-induced coagulation induces organ damage in sepsis

(2017) Susan J. Allison   Nature Reviews Nephrology

Sepsis for the anaesthetist

(2016) M.E. Nunnally   BRITISH JOURNAL OF ANAESTHESIA

Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

(2016) Anders Perner et al.   INTENSIVE CARE MEDICINE

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps: Mechanisms of formation and role in health and disease

(2014) N. V. Vorobjeva et al.   BIOCHEMISTRY-MOSCOW

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages

(2014) Kenneth R. Feingold et al.   JOURNAL OF LIPID RESEARCH

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE