Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation

RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells

(2020) Jennifer Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Response to inhibition of receptor‐interacting protein kinase 1 (RIPK1) in active plaque psoriasis: a randomized placebo‐controlled study

(2020) Kathleen Weisel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

(2020) Michael Devos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis

(2018) Ronald A. Panganiban et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death

(2018) Mark Lötzerich et al.   Cell Death & Disease

Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation

(2018) Sarah N. Croft et al.   Scientific Reports

RIPK3 in cell death and inflammation: the good, the bad, and the ugly

(2017) Susana Orozco et al.   IMMUNOLOGICAL REVIEWS

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

Necroptosis-independent signaling by the RIP kinases in inflammation

(2016) Kenta Moriwaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

House dust mite–induced asthma causes oxidative damage and DNA double-strand breaks in the lungs

(2016) Tze Khee Chan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

Interleukin 1α and the inflammatory process

(2016) Nelson C Di Paolo et al.   NATURE IMMUNOLOGY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

(2016) Jonathan Maelfait et al.   PLoS Pathogens

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

(2015) Daniel Lafkas et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

(2015) Christopher M. Evans et al.   Nature Communications

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Staying Alive: Cell Death in Antiviral Immunity

(2014) Jason W. Upton et al.   MOLECULAR CELL

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Determination of apoptotic and necrotic cell death in vitro and in vivo

(2013) Tom Vanden Berghe et al.   METHODS

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

(2013) Ricardo Weinlich et al.   Cell Reports

Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis

(2012) Nikos Oikonomou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

(2011) Marion C. Bonnet et al.   IMMUNITY

Innate and adaptive immune responses to cell death

(2011) Kenneth L. Rock et al.   IMMUNOLOGICAL REVIEWS

Epithelial Apoptosis and Loss in Airways of Children with Asthma

(2011) Chunju Zhou et al.   JOURNAL OF ASTHMA

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Oligodendrocyte-Specific FADD Deletion Protects Mice from Autoimmune-Mediated Demyelination

(2010) C. Mc Guire et al.   JOURNAL OF IMMUNOLOGY

Role of viral respiratory infections in asthma and asthma exacerbations

(2010) William W Busse et al.   LANCET

Creola Bodies in Infancy with Respiratory Syncytial Virus Bronchiolitis Predict the Development of Asthma

(2010) Yumi Yamada et al.   ALLERGOLOGY INTERNATIONAL

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

(2009) Andrew Kovalenko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

The Airway Epithelium is Central to the Pathogenesis of Asthma

(2008) Stephen T. Holgate   ALLERGOLOGY INTERNATIONAL