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Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

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PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

(2022) Hai-Liang Zhang et al.   NATURE CELL BIOLOGY

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

(2022) Peng Liao et al.   CANCER CELL

Deubiquitinase-targeting chimeras for targeted protein stabilization

(2022) Nathaniel J. Henning et al.   Nature Chemical Biology

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

(2022) Gizem Günes Günsel et al.   Nature Communications

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

(2022) Brent R. Stockwell   CELL

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

(2022) Eikan Mishima et al.   NATURE

Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

(2022) Dong-Hyun Kim et al.   Redox Biology

Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis

(2022) Zijun Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals

(2022) Uladzimir Barayeu et al.   Nature Chemical Biology

Cryo-EM structures of the active NLRP3 inflammasome disc

(2022) Le Xiao et al.   NATURE

Cell death pathways: intricate connections and disease implications

(2021) Matthias Kist et al.   EMBO JOURNAL

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A compendium of kinetic modulatory profiles identifies ferroptosis regulators

(2021) Megan Conlon et al.   Nature Chemical Biology

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

(2021) Wan-Yang Sun et al.   Nature Chemical Biology

E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis

(2021) Pucheng Mei et al.   CELL DEATH AND DIFFERENTIATION

Targeting Parthanatos in Ischemic Stroke

(2021) Raymond C. Koehler et al.   Frontiers in Neurology

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

(2021) Snehlata Kumari et al.   Life Science Alliance

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

(2021) Emeline Dierge et al.   Cell Metabolism

Targeting prominin2 transcription to overcome ferroptosis resistance in cancer

(2021) Caitlin W Brown et al.   EMBO Molecular Medicine

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Emerging role of PARP‐1 and PARthanatos in ischemic stroke

(2021) Shuiqiao Liu et al.   JOURNAL OF NEUROCHEMISTRY

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

(2021) Wulf Tonnus et al.   Nature Communications

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

(2021) Tiantian Tang et al.   Frontiers in Immunology

MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling

(2021) Shan Xin et al.   CELL DEATH AND DIFFERENTIATION

OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice

(2021) Hannah Schünke et al.   Nature Communications

Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma

(2021) Wanlu Du et al.   Cell Reports

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia

(2020) Juan Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Necrosulfonamide Ameliorates Neurological Impairment in Spinal Cord Injury by Improving Antioxidative Capacity

(2020) Jianhang Jiao et al.   Frontiers in Pharmacology

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

(2020) Plamena R. Angelova et al.   CELL DEATH AND DIFFERENTIATION

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Emerging New Concepts of Degrader Technologies

(2020) Yu Ding et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

(2020) Lea L. Friker et al.   Cell Reports

Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals

(2020) Jia-Fei Poon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

(2020) Lauren Mifflin et al.   NATURE REVIEWS DRUG DISCOVERY

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

(2020) Marco Gatti et al.   Cell Reports

HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection

(2020) Yu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Poly(ADP-ribose) polymerase inhibition: past, present and future

(2020) Nicola J. Curtin et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases

(2020) Marcus Conrad et al.   TRENDS IN MOLECULAR MEDICINE

Resolving the paradox of ferroptotic cell death: ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

(2020) Tamil S. Anthonymuthu et al.   Redox Biology

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

(2020) Lohans Pedrera et al.   CELL DEATH AND DIFFERENTIATION

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

(2020) Bo Yan et al.   MOLECULAR CELL

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis

(2020) Xin Hong et al.   Cancer Discovery

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

(2019) Snahel Patel et al.   CELL DEATH AND DIFFERENTIATION

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial

(2019) Michael Friedlander et al.   LANCET ONCOLOGY

Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation

(2019) Kim Newton   Cold Spring Harbor Perspectives in Biology

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

(2019) Meng-Chen Lu et al.   Redox Biology

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

(2018) Miguel Mompeán et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome

(2018) Matija Zelic et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships

(2018) Masato Yoshikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation

(2018) Seung-Won Choi et al.   MOLECULAR CELL

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

(2018) Heike Miess et al.   ONCOGENE

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

(2018) Carlo Marchetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

(2018) Fiachra Humphries et al.   Nature Communications

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

(2018) Pablo Palazón‐Riquelme et al.   EMBO REPORTS

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

(2018) Wei Wang et al.   CANCER CELL

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model

(2018) Inbar Shlomovitz et al.   FEBS Journal

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

(2018) Lars Devisscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions

(2017) Saravana Babu Chidambaram et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Eosinophils Undergo Caspase-1–Mediated Pyroptosis in Response to Necrotic Liver Cells

(2017) Daphne Palacios-Macapagal et al.   JOURNAL OF IMMUNOLOGY

ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages

(2017) Akira Kawashima et al.   JOURNAL OF IMMUNOLOGY

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

(2017) Yan Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

(2017) C. Delehouzé et al.   Scientific Reports

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Necrostatin-1 protects against oleic acid-induced acute respiratory distress syndrome in rats

(2016) Long Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

(2016) Seung‐Hoon Yang et al.   EMBO Molecular Medicine

Methanobactin reverses acute liver failure in a rat model of Wilson disease

(2016) Josef Lichtmannegger et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

(2016) Sam Hofmans et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

(2016) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

(2016) Y. Wang et al.   SCIENCE

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

(2016) Matous Hrdinka et al.   Cell Reports

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

(2016) Michelle Vincendeau et al.   Scientific Reports

Coronary Endothelial Dysfunction Induced by Nucleotide Oligomerization Domain-Like Receptor Protein with Pyrin Domain Containing 3 Inflammasome Activation During Hypercholesterolemia: Beyond Inflammation

(2015) Yang Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

(2015) Vivien I. Maltez et al.   IMMUNITY

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase

(2015) SeungHye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent

(2015) Bing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1

(2015) Malek Najjar et al.   Cell Reports

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

(2014) Mark Luedde et al.   CARDIOVASCULAR RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

(2014) Paul R. Elliott et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Poly(ADP-ribose) polymerase-1-induced NAD+ depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation

(2013) Tiina M. Kauppinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos

(2013) A A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors

(2013) Na Ye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia–reperfusion in vivo

(2012) Martinus I. F. J. Oerlemans et al.   BASIC RESEARCH IN CARDIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The spatial and temporal organization of ubiquitin networks

(2011) Caroline Grabbe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

(2011) H. C. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety

(2010) Matthew B. Boxer et al.   ChemMedChem

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

(2010) Thomas D. Penning et al.   JOURNAL OF MEDICINAL CHEMISTRY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

NEMO/IKKγ regulates an early NF-κB-independent cell-death checkpoint during TNF signaling

(2009) D Legarda-Addison et al.   CELL DEATH AND DIFFERENTIATION

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TNF-α Induces Two Distinct Caspase-8 Activation Pathways

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Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

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Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

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cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

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