Receptor‐interacting protein 3‐phosphorylated Ca 2+ /calmodulin‐dependent protein kinase II and mixed lineage kinase domain‐like protein mediate intracerebral hemorrhage‐induced neuronal necroptosis

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke

(2021) Yong-Ming Zhu et al.   Translational Stroke Research

RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice

(2021) Yang Xu et al.   NEUROSCIENCE LETTERS

Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development

(2020) Yue Hu et al.   CELL DEATH AND DIFFERENTIATION

Necrosulfonamide Ameliorates Neurological Impairment in Spinal Cord Injury by Improving Antioxidative Capacity

(2020) Jianhang Jiao et al.   Frontiers in Pharmacology

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

(2020) Lili Wang et al.   Frontiers in Cell and Developmental Biology

Rbfox-1 contributes to CaMKIIα expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124

(2020) Fang Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

(2020) Xiao-Hui Tang et al.   Journal of Neuroinflammation

Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice

(2020) Sevda Lule et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

AAV/BBB-Mediated Gene Transfer of CHIP Attenuates Brain Injury Following Experimental Intracerebral Hemorrhage

(2019) Shuo Zhang et al.   Translational Stroke Research

Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage

(2019) Jianan Lu et al.   Frontiers in Immunology

RIP3 inhibition protects locomotion function through ameliorating mitochondrial antioxidative capacity after spinal cord injury

(2019) Yang Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Intracranial Hypertension and Cerebral Perfusion Pressure Insults in Adult Hypertensive Intraventricular Hemorrhage

(2019) Wendy C. Ziai et al.   CRITICAL CARE MEDICINE

RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis

(2019) Shuai Yuan et al.   NEUROBIOLOGY OF DISEASE

Botch protects neurons from ischemic insult by antagonizing Notch-mediated neuroinflammation

(2019) Hao Li et al.   EXPERIMENTAL NEUROLOGY

Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

(2018) Shengpan Chen et al.   Journal of Neuroinflammation

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

(2018) Emma J. Petrie et al.   Nature Communications

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

(2018) Zhuwei Zhang et al.   BRAIN RESEARCH

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

Coupling Between Interleukin-1R1 and Necrosome Complex Involves in Hemin-Induced Neuronal Necroptosis After Intracranial Hemorrhage

(2018) Xiang Chu et al.   STROKE

An Update On Medical Treatment for Intracerebral Hemorrhage

(2018) Xiang Li et al.   Translational Stroke Research

Acetazolamide Mitigates Intracranial Pressure Spikes Without Affecting Functional Outcome After Experimental Hemorrhagic Stroke

(2018) Michael R. Williamson et al.   Translational Stroke Research

Intracerebral haemorrhage: current approaches to acute management

(2018) Charlotte Cordonnier et al.   LANCET

RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

(2017) Yi Qu et al.   Cell Death & Disease

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro

(2017) Haitao Shen et al.   Cell Death & Disease

Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury

(2017) Zhong Wang et al.   Translational Stroke Research

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of two phosphorylation sites essential for annexin A1 in blood–brain barrier protection after experimental intracerebral hemorrhage in rats

(2016) Zhong Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Role of Glibenclamide in Brain Injury After Intracerebral Hemorrhage

(2016) Bing Jiang et al.   Translational Stroke Research

Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation

(2015) Wei Ding et al.   BMC NEUROSCIENCE

Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid Hemorrhage in Rats

(2015) Haitao Shen et al.   STROKE

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Confers Acute Neuroprotection After Intracerebral Hemorrhage in Mice

(2015) Sangeetha Sukumari-Ramesh et al.   Translational Stroke Research

Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury

(2014) Y. Wang et al.   NEUROSCIENCE

Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway

(2013) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial

(2013) A David Mendelow et al.   LANCET

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Regulates Cardiac Sodium Channel NaV1.5 Gating by Multiple Phosphorylation Sites

(2012) Nicole M. Ashpole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model

(2012) Yao-Qi Wang et al.   NEUROCHEMICAL RESEARCH

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

CaV1.2  -subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations

(2010) O. M. Koval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells

(2009) Melissa A Fleegal-DeMotta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats

(2008) Jean-Christophe Copin et al.   EXPERIMENTAL NEUROLOGY

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Targeting TNF-α receptors for neurotherapeutics

(2008) Wayne Chadwick et al.   TRENDS IN NEUROSCIENCES