Interferon-γ Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL

TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during Respiratory Syncytial Virus infection

(2021) Leonardo Duarte Santos et al.   EUROPEAN RESPIRATORY JOURNAL

Control of Macrophage Inflammation by P2Y Purinergic Receptors

(2021) Dominik Klaver et al.   Cells

Management of Acute Lung Injury: Palmitoylethanolamide as a New Approach

(2021) Alessio Filippo Peritore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis

(2021) Ting Zhou et al.   Cells

Pathophysiology of coronavirus-19 disease acute lung injury

(2021) Luigi Camporota et al.   Current Opinion in Critical Care

The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

(2020) Hamed Akbari et al.   LIFE SCIENCES

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis

(2020) Norberto Gonzalez-Juarbe et al.   Cell Reports

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Cytokine profile and disease severity in patients with COVID-19

(2020) Ali Ghazavi et al.   CYTOKINE

Enhanced RIPK3 kinase activity-dependent lytic cell death in M1 but not M2 macrophages

(2020) Qin Hao et al.   MOLECULAR IMMUNOLOGY

Extracellular adenosine 5′-triphosphate in pulmonary disorders

(2020) Amir Pelleg   BIOCHEMICAL PHARMACOLOGY

Necrosis Rather Than Apoptosis is The Dominant form of Alveolar Epithelial Cell Death In Lipopolysaccharide-Induced Experimental Acute Respiratory Distress Syndrome Model

(2019) Nao Tamada et al.   SHOCK

JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model

(2019) Qing Liu et al.   LABORATORY INVESTIGATION

Collateral Damage: Necroptosis in the Development of Lung Injury

(2019) Hilary Faust et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nucleic Acid Sensors and Programmed Cell Death

(2019) Jonathan Maelfait et al.   JOURNAL OF MOLECULAR BIOLOGY

Acute Respiratory Distress Syndrome

(2018) Eddy Fan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis

(2018) Alexandra C. Bolognese et al.   SURGERY

RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

(2018) Jingxian Chen et al.   Journal of Translational Medicine

RIP kinases as modulators of inflammation and immunity

(2018) Sudan He et al.   NATURE IMMUNOLOGY

Deficiency of receptor-interacting protein kinase 3 (RIPK3) attenuates inflammation and organ injury in neonatal sepsis

(2017) Laura W. Hansen et al.   JOURNAL OF PEDIATRIC SURGERY

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis

(2017) L D Bos et al.   THORAX

Necroptosis as a potential therapeutic target in multiple organ dysfunction syndrome

(2017) Yao-Li Cui et al.   Oncotarget

Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis

(2017) Seung Hoon Lee et al.   Scientific Reports

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Receptor Interacting Protein 3-Mediated Necroptosis Promotes Lipopolysaccharide-Induced Inflammation and Acute Respiratory Distress Syndrome in Mice

(2016) Linlin Wang et al.   PLoS One

Inflammatory impact of IFN-γ in CD8+ T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways

(2015) Chilakamarti V. Ramana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanisms of Interferon-γ Production by Neutrophils and Its Function duringStreptococcus pneumoniaePneumonia

(2015) John C. Gomez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Mouse Models of Acute Respiratory Distress Syndrome

(2015) Famke Aeffner et al.   TOXICOLOGIC PATHOLOGY

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

(2015) Norberto González-Juarbe et al.   PLoS Pathogens

Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation

(2014) Danielle Y. Qing et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-IFN-  and Peptide-Tolerization Therapies Inhibit Acute Lung Injury Induced by Cross-Reactive Influenza A-Specific Memory T Cells

(2013) M. F. Wlodarczyk et al.   JOURNAL OF IMMUNOLOGY

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis

(2011) R. J. Thapa et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-  and TNF-  by Gr-1+ monocytes

(2010) T. Aoyagi et al.   INTERNATIONAL IMMUNOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Role of the pulmonary epithelium and inflammatory signals in acute lung injury

(2008) Anne M Manicone   Expert Review of Clinical Immunology