MTOR Suppresses Cigarette Smoke–Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease

Autophagy plays an essential role in cigarette smoke-induced expression of MUC5AC in airway epithelium

(2016) Jie-Sen Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

(2016) Akihisa Mitani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

(2016) Yue Hu et al.   Autophagy

Safety of mTOR inhibitors in breast cancer

(2016) Hana Študentová et al.   Expert Opinion On Drug Safety

Inflammatory Markers and the Risk of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

(2016) Bin Su et al.   PLoS One

Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium

(2015) Zhi-Hua Chen et al.   Autophagy

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Temsirolimus induces surfactant lipid accumulation and lung inflammation in mice

(2014) Satoshi Washino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Elastase induces lung epithelial cell autophagy through placental growth factor

(2014) Hsin-Han Hou et al.   Autophagy

Oxidative damage induced by cigarette smoke exposure in mice: impact on lung tissue and diaphragm muscle,

(2014) Samanta Portão de Carlos et al.   Jornal Brasileiro de Pneumologia

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR and autophagy in regulation of acute lung injury: a review and perspective

(2014) Yue Hu et al.   MICROBES AND INFECTION

Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NF-κB pathway

(2013) Inés López-Alonso et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

(2013) Hilaire C. Lam et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

Regulation of Cigarette Smoke (CS)-Induced Autophagy by Nrf2

(2013) Lingxiang Zhu et al.   PLoS One

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Autophagy is required for the activation of NFκB

(2012) Alfredo Criollo et al.   CELL CYCLE

Chronic obstructive pulmonary disease

(2012) Marc Decramer et al.   LANCET

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

Shifting the balance of mitochondrial apoptosis: therapeutic perspectives

(2012) Simone Fulda   Frontiers in Oncology

Cigarette Smoke Components Induce Matrix Metalloproteinase-1 in Aortic Endothelial Cells through Inhibition of mTOR Signaling

(2011) Vincent Lemaître et al.   TOXICOLOGICAL SCIENCES

Pathogenic triad in COPD: oxidative stress, protease–antiprotease imbalance, and inflammation

(2011) Bernard Fischer et al.   International Journal of Chronic Obstructive Pulmonary Disease

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

(2010) Laura Bonapace et al.   JOURNAL OF CLINICAL INVESTIGATION

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

(2008) Zhi-Hua Chen et al.   PLoS One