EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis

Updated Insights on EGFR Signaling Pathways in Glioma

(2021) Alexandru Oprita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression

(2021) Qiong Xue et al.   Cell Death Discovery

Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin

(2020) Xingyue Qin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma

(2019) Gao Guo et al.   NEURO-ONCOLOGY

Blockade of EGFR Activation Promotes TNF-Induced Lung Epithelial Cell Apoptosis and Pulmonary Injury

(2019) Toshimitsu Yamaoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation

(2019) Jing Tang et al.   Protein & Cell

A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice

(2019) Jolien Vandewalle et al.   Frontiers in Immunology

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer

(2018) Ke Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis

(2018) Huyan Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

(2018) Alastair Proudfoot et al.   THORAX

A TNF–JNK–Axl–ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma

(2017) Gao Guo et al.   NATURE NEUROSCIENCE

EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis

(2017) D M Hardbower et al.   ONCOGENE

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

Necroptosis and Inflammation

(2016) Kim Newton et al.   Annual Review of Biochemistry

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

EGFR Fusions as Novel Therapeutic Targets in Lung Cancer

(2016) K. Konduri et al.   Cancer Discovery

Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer

(2015) C. S. Milagre et al.   CANCER RESEARCH

EGFR kinase activity is required for TLR4 signaling and the septic shock response

(2015) S. Chattopadhyay et al.   EMBO REPORTS

The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia

(2015) Xuegang Sun et al.   Oncotarget

Lapatinib Ameliorates Experimental Arthritis in Rats

(2014) Metin Ozgen et al.   INFLAMMATION

Activation of the Epidermal Growth Factor Receptor in Macrophages Regulates Cytokine Production and Experimental Colitis

(2014) N. Lu et al.   JOURNAL OF IMMUNOLOGY

Evaluating the Efficacy and Safety of Two Doses of the Polyclonal Anti-Tumor Necrosis Factor-α Fragment Antibody AZD9773 in Adult Patients With Severe Sepsis and/or Septic Shock

(2013) Gordon R. Bernard et al.   CRITICAL CARE MEDICINE

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

HER2 Amplification: A Potential Mechanism of Acquired Resistance to EGFR Inhibition in EGFR -Mutant Lung Cancers That Lack the Second-Site EGFR T790M Mutation

(2012) Ken Takezawa et al.   Cancer Discovery

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Epidermal Growth Factor Receptor Mediates Tumor Necrosis Factor-α-induced Activation of the ERK/GEF-H1/RhoA Pathway in Tubular Epithelium

(2011) Eli Kakiashvili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR-Mutant Lung Adenocarcinomas Treated First-Line with the Novel EGFR Inhibitor, XL647, Can Subsequently Retain Moderate Sensitivity to Erlotinib

(2011) Juliann Chmielecki et al.   Journal of Thoracic Oncology

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(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis

(2009) Fang Yan et al.   GASTROENTEROLOGY

PKC Phosphorylation of TRAF2 Mediates IKKα/β Recruitment and K63-Linked Polyubiquitination

(2009) Shitao Li et al.   MOLECULAR CELL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology