PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis

From organic and inorganic phosphates to valvular and vascular calcifications

(2021) Magnus Bäck et al.   CARDIOVASCULAR RESEARCH

MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress

(2021) Lynda Bourebaba et al.   Stem Cell Research & Therapy

Role of oxidative stress in calcific aortic valve disease and its therapeutic implications

(2021) Harry Z E Greenberg et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?

(2021) Kanchan Phadwal et al.   Frontiers in Cell and Developmental Biology

Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement

(2020) Raj R. Makkar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

(2020) Yifan Ge et al.   eLife

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress

(2020) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR‐204‐5p/DPP4 signaling in valvular interstitial cells

(2020) Yongjun Wang et al.   JOURNAL OF PINEAL RESEARCH

TAVI Represents an Anti-Inflammatory Therapy via Reduction of Shear Stress Induced, Piezo-1-Mediated Monocyte Activation

(2020) Sara Baratchi et al.   CIRCULATION

Recent advance on PTP1B inhibitors and their biomedical applications

(2020) Bigyan Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aldo-keto reductase family 1 member B induces aortic valve calcification by activating hippo signaling in valvular interstitial cells

(2020) Chenyang Gao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Graded murine wire-induced aortic valve stenosis model mimics human functional and morphological disease phenotype

(2019) Sven Thomas Niepmann et al.   Clinical Research in Cardiology

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease

(2018) Kyoung Im Cho et al.   ATHEROSCLEROSIS

Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis

(2018) Rihab Bouchareb et al.   EUROPEAN HEART JOURNAL

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

(2017) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association Between Cardiovascular Risk Factors and Aortic Stenosis

(2017) Andrew T. Yan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE −/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

(2017) D. Thompson et al.   Molecular Metabolism

Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice

(2016) Rajinikanth Gogiraju et al.   CARDIOVASCULAR RESEARCH

Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic StenosisNovelty and Significance

(2016) Louis Simard et al.   CIRCULATION RESEARCH

The metal face of protein tyrosine phosphatase 1B

(2016) Elisa Bellomo et al.   COORDINATION CHEMISTRY REVIEWS

Role of protein tyrosine phosphatase 1B in cardiovascular diseases

(2016) Pierre-Alain Thiebaut et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcification in Aortic Stenosis

(2015) Tania A. Pawade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gene Deletion of Protein Tyrosine Phosphatase 1B Protects Against Sepsis-Induced Cardiovascular Dysfunction and Mortality

(2014) David Coquerel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction

(2014) Catherine M. Otto et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Mouse Model of Aortic Valve Stenosis Induced by Direct Wire Injury

(2013) Shintaro Honda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fibrocalcific Aortic Valve Disease

(2013) Robert M. Weiss et al.   CIRCULATION RESEARCH

Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes

(2012) Conrad Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of mitochondria in apoptosis

(2011) Seon-Yong Jeong et al.   BMB Reports

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Molecular Imaging Insights Into Early Inflammatory Stages of Arterial and Aortic Valve Calcification

(2011) Sophie E.P. New et al.   CIRCULATION RESEARCH

Functional impact of PTP1B-mediated Src regulation on oxidative phosphorylation in rat brain mitochondria

(2010) Etienne Hébert Chatelain et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery

(2010) Martin B. Leon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans

(2008) Jordan D. Miller et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis

(2008) Anne B. Rossebø et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidant Generation Predominates Around Calcifying Foci and Enhances Progression of Aortic Valve Calcification

(2007) Marcel Liberman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY