Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model

Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-κB pathway

(2020) Yinyin Ye et al.   INFLAMMATION RESEARCH

Network Pharmacology-Based Analysis of the Pharmacological Mechanisms of Aloperine on Cardiovascular Disease

(2020) Bingwu Huang et al.   Evidence-based Complementary and Alternative Medicine

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection

(2019) Chu Qin et al.   Biomed Research International

Necrosis Rather Than Apoptosis is The Dominant form of Alveolar Epithelial Cell Death In Lipopolysaccharide-Induced Experimental Acute Respiratory Distress Syndrome Model

(2019) Nao Tamada et al.   SHOCK

TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury

(2019) Xiaojing Wu et al.   INFLAMMATION RESEARCH

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure

(2019) Alpha A. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sophora alopecuroides L.: An ethnopharmacological, phytochemical, and pharmacological review

(2019) Xinxin Deng et al.   JOURNAL OF ETHNOPHARMACOLOGY

PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

(2019) Jia Shi et al.   LABORATORY INVESTIGATION

LPS-induced Acute Lung Injury Involves NF-κB–mediated Downregulation of SOX18

(2018) Christine M. Gross et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of insulin-like growth factor receptor-1 reduces necroptosis-related markers and attenuates LPS-induced lung injury in mice

(2018) Su Hwan Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Necroptosis Contributes to Urban Particulate Matter-Induced Airway Epithelial Injury

(2018) Feng Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress

(2018) Jiaji Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

(2018) Xiaozhen Chen et al.   MEDIATORS OF INFLAMMATION

The Role of Macrophages in the Pathogenesis of ALI/ARDS

(2018) Xiaofang Huang et al.   MEDIATORS OF INFLAMMATION

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

Ulinastatin Protects Against LPS-Induced Acute Lung Injury by Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators

(2018) Chao Cao et al.   SHOCK

Mitochondrial peptides cause proinflammatory responses in the alveolar epithelium via FPR-1, MAPKs, and AKT: a potential mechanism involved in acute lung injury

(2018) Xue Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neuro-protective effects of aloperine in an Alzheimer’s disease cellular model

(2018) Jing Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model

(2018) Wen-Jing Zhong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

(2018) Jingxian Chen et al.   Journal of Translational Medicine

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression

(2017) Xiaoxia Fu et al.   MEDIATORS OF INFLAMMATION

Acute Respiratory Distress Syndrome

(2017) B. Taylor Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

Necroptosis: A new way of dying?

(2016) Britt Hanson   CANCER BIOLOGY & THERAPY

Soluble Epoxide Hydrolase Inhibitor Suppresses the Expression of Triggering Receptor Expressed on Myeloid Cells-1 by Inhibiting NF-kB Activation in Murine Macrophage

(2016) Liang Dong et al.   INFLAMMATION

Aloperine attenuates hydrogen peroxide-induced injury via anti-apoptotic activity and suppression of the nuclear factor-κB signaling pathway

(2016) Dongliang Ren et al.   Experimental and Therapeutic Medicine

RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF

(2016) Yang Xu et al.   Scientific Reports

Relationship between elevated soluble CD74 and severity of experimental and clinical ALI/ARDS

(2016) Guosheng Wu et al.   Scientific Reports

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

(2015) Sabine Vettorazzi et al.   Nature Communications

Resolution of Pulmonary Edema. Thirty Years of Progress

(2014) Michael A. Matthay   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation

(2014) Danielle Y. Qing et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Aloperine attenuated neuropathic pain induced by chronic constriction injury via anti-oxidation activity and suppression of the nuclear factor kappa B pathway

(2014) Ya-Qiong Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways

(2014) Ya-Li Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY