Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma

RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells

(2020) Jennifer Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

(2020) Zhixuan Loh et al.   PLoS Pathogens

Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity

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PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN- λ production

(2018) Rhiannon B. Werder et al.   Science Translational Medicine

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

(2017) Manuel A.R. Ferreira et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

(2017) Jaisy Arikkatt et al.   eLife

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)

(2017) Mathew Suji Eapen et al.   Scientific Reports

Aeroallergen-induced IL-33 predisposes to respiratory virus–induced asthma by dampening antiviral immunity

(2016) Jason P. Lynch et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alternative splicing of interleukin-33 and type 2 inflammation in asthma

(2016) Erin D. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33

(2015) Christina A. Christianson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

(2015) Md Ashik Ullah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33

(2015) Jenny Calvén et al.   Journal of Translational Medicine

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations

(2014) Robert J. Snelgrove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation

(2014) Md Ashik Ullah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

(2013) Derek E. Byers et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of high-mobility group box-1 (HMGB1) in the pathogenesis of asthma

(2012) E.-J. Shim et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2

(2011) Scott Boitano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis

(2011) R. Kamekura et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma

(2011) S. Bunyavanich et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

(2010) T. Müller et al.   ALLERGY

Coupled Nucleotide and Mucin Hypersecretion from Goblet-Cell Metaplastic Human Airway Epithelium

(2010) Seiko F. Okada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

P2Y13 receptor is critical for reverse cholesterol transport

(2010) Aurélie C. Fabre et al.   HEPATOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients

(2010) Tetsuya Watanabe et al.   RESPIRATORY MEDICINE

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12receptor

(2009) Sailaja Paruchuri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells

(2009) D. Prefontaine et al.   JOURNAL OF IMMUNOLOGY

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

P2Y receptor signaling regulates phenotype and IFN-  secretion of human plasmacytoid dendritic cells

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