Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites
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Title
Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites
Authors
Keywords
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Journal
Frontiers in Neuroscience
Volume 16, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-06-21
DOI
10.3389/fnins.2022.900338
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Note: Only part of the references are listed.- Fighting Parkinson’s disease: The return of the mitochondria
- (2022) Kevin Zambrano et al. MITOCHONDRION
- Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
- (2022) Jasmine Cisneros et al. TRENDS IN NEUROSCIENCES
- Lysosomal dysfunction in neurodegeneration: emerging concepts and methods
- (2022) Vinod Udayar et al. TRENDS IN NEUROSCIENCES
- Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites
- (2021) Haoxi Wu et al. DEVELOPMENTAL CELL
- Neutral lipids as early biomarkers of cellular fate: the case of α-synuclein overexpression
- (2021) Natalia P. Alza et al. Cell Death & Disease
- Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
- (2021) Faiz Rasul et al. Nature Communications
- ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
- (2021) Guoyuan Qi et al. Cell Reports
- Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
- (2021) Sabrina Contino et al. Frontiers in Neuroscience
- The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites
- (2021) Samantha Katarzyna Dziurdzik et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
- (2021) Grzegorz Sienski et al. Science Translational Medicine
- An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions
- (2021) Jingru Wang et al. Nature Communications
- Parkinson’s Disease: Alterations in Iron and Redox Biology as a Key to Unlock Therapeutic Strategies
- (2021) L. Ma et al. Redox Biology
- Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease
- (2021) Stefanie Smolders et al. Acta Neuropathologica Communications
- Mind the Gap: Mitochondria and the Endoplasmic Reticulum in Neurodegenerative Diseases
- (2021) Nuno Santos Leal et al. Biomedicines
- Interorganelle communication, aging, and neurodegeneration
- (2021) Maja Petkovic et al. GENES & DEVELOPMENT
- Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized ER subdomains
- (2021) Amit S. Joshi et al. MOLECULAR BIOLOGY OF THE CELL
- Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
- (2021) Soojin Kim et al. Nature Communications
- α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
- (2021) Morgan G. Stykel et al. Cell Reports
- Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson’s Disease
- (2021) Philipp Portz et al. Cells
- Dysfunction of Synaptic Vesicle Endocytosis in Parkinson’s Disease
- (2021) Li Zou et al. Frontiers in Integrative Neuroscience
- Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration
- (2021) Dmitry Lim et al. CELL CALCIUM
- Linking transport and translation of mRNAs with endosomes and mitochondria
- (2021) Kira Müntjes et al. EMBO REPORTS
- Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum
- (2021) Rosanne Wouters et al. JOURNAL OF CELL BIOLOGY
- Correction: VPS13D bridges the ER to mitochondria and peroxisomes via Miro
- (2021) Andrés Guillén-Samander et al. JOURNAL OF CELL BIOLOGY
- Overexpression of α‐synuclein inhibits mitochondrial Ca 2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction
- (2021) Adolfo Garcia Erustes et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The Vacuole and Mitochondria Patch (vCLAMP) Protein Vam6 is Crucial for Autophagy in Candida albicans
- (2021) Xiaolong Mao et al. MYCOPATHOLOGIA
- Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion
- (2021) Qilin Tang et al. Cell Death & Disease
- ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
- (2021) Nazmiye Özkan et al. Nature Communications
- Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering
- (2021) Haider Khan et al. Scientific Reports
- Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough
- (2021) Upasana Ganguly et al. Frontiers in Aging Neuroscience
- Miro1 Impairment in a Parkinson’s At-Risk Cohort
- (2021) David Nguyen et al. Frontiers in Molecular Neuroscience
- Lipid Droplet-Organelle Contact Sites as Hubs for Fatty Acid Metabolism, Trafficking, and Metabolic Channeling
- (2021) Mike F. Renne et al. Frontiers in Cell and Developmental Biology
- Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association
- (2021) Maxime Teixeira et al. Biomolecules
- Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport
- (2021) Marianna Leonzino et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons
- (2021) Valentina Tedeschi et al. CELL CALCIUM
- PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness
- (2021) Nicolas Rabas et al. JOURNAL OF CELL BIOLOGY
- VPS13C-associated Parkinson's disease: Two novel cases and review of the literature
- (2021) Edoardo Monfrini et al. PARKINSONISM & RELATED DISORDERS
- Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes
- (2021) Matthew J. Moulton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
- (2021) Rebekah Rakotonirina-Ricquebourg et al. PROGRESS IN LIPID RESEARCH
- Cellular senescence links mitochondria-ER contacts and aging
- (2021) Dorian V. Ziegler et al. Communications Biology
- Autophagy in Parkinson's Disease
- (2020) Xu Hou et al. JOURNAL OF MOLECULAR BIOLOGY
- ATP13A2 deficiency disrupts lysosomal polyamine export
- (2020) Sarah van Veen et al. NATURE
- Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination
- (2020) Su Jin Ham et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles
- (2020) Luis D. Bernal-Conde et al. Frontiers in Neuroscience
- The Role of VPS35 in the Pathobiology of Parkinson’s Disease
- (2020) Jenny Sassone et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
- (2020) Clara Berenguer-Escuder et al. HUMAN MOLECULAR GENETICS
- Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis
- (2020) Norbert Volkmar et al. JOURNAL OF CELL SCIENCE
- Contribution of the Presenilins in the cell biology, structure and function of γ-secretase
- (2020) Abril Escamilla-Ayala et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Glucocerebrosidase Defects as a Major Risk Factor for Parkinson’s Disease
- (2020) Micol Avenali et al. Frontiers in Aging Neuroscience
- Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases
- (2020) Giorgio Santoni et al. Frontiers in Physiology
- Current and Emerging Approaches for Studying Inter-Organelle Membrane Contact Sites
- (2020) Xue Huang et al. Frontiers in Cell and Developmental Biology
- ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs
- (2020) Marion Weber-Boyvat et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Tether Me, Tether Me Not—Dynamic Organelle Contact Sites in Metabolic Rewiring
- (2020) Maria Bohnert DEVELOPMENTAL CELL
- Molecular Basis of Mitochondrial and Peroxisomal Division Machineries
- (2020) Yuuta Imoto et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structure of the ER membrane complex, a transmembrane-domain insertase
- (2020) Lin Bai et al. NATURE
- Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1
- (2020) Wesley Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The substrate repertoire of γ-secretase/presenilin
- (2020) Gökhan Güner et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria
- (2020) Yael Elbaz-Alon et al. Nature Communications
- DRP1 deficiency induces mitochondrial dysfunction and oxidative stress-mediated apoptosis during porcine oocyte maturation
- (2020) Haolin Zhang et al. Journal of Animal Science and Biotechnology
- Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance
- (2020) Oeystein Roed Brekk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease
- (2020) Dajana Grossmann et al. Frontiers in Neurology
- Mitochondria-ER Tethering in Neurodegenerative Diseases
- (2020) Reza Raeisossadati et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Targeting mitophagy in Parkinson's disease
- (2020) Emily H. Clark et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress
- (2020) Stephanie Vrijsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy
- (2020) Ana Belen Malpartida et al. TRENDS IN BIOCHEMICAL SCIENCES
- The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes
- (2020) Meng Lu et al. Science Advances
- Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models
- (2020) Nuno Santos Leal et al. Cells
- Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
- (2019) Jean-Michel Cioni et al. CELL
- Altered interplay between endoplasmic reticulum and mitochondria in Charcot–Marie–Tooth type 2A neuropathy
- (2019) Nathalie Bernard-Marissal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
- (2019) D. Allan Butterfield et al. NATURE REVIEWS NEUROSCIENCE
- Cerebellar ataxia disease–associated Snx14 promotes lipid droplet growth at ER–droplet contacts
- (2019) Sanchari Datta et al. JOURNAL OF CELL BIOLOGY
- VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation
- (2019) Sandra Muñoz-Braceras et al. Disease Models & Mechanisms
- Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization
- (2019) Ilan Y. Benador et al. Cell Metabolism
- Familial Alzheimer’s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis
- (2019) Elisa Greotti et al. CELL CALCIUM
- The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation
- (2019) Dongfang Li et al. Cell Reports
- Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
- (2019) King Faisal Yambire et al. eLife
- Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes
- (2019) Jee Hoon Lee et al. Acta Neuropathologica Communications
- Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson’s disease
- (2019) Dajana Grossmann et al. ANTIOXIDANTS & REDOX SIGNALING
- Role of the endolysosomal system in Parkinson’s disease
- (2019) D. J. Vidyadhara et al. JOURNAL OF NEUROCHEMISTRY
- PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation
- (2019) Cristina Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- DNA sensing by the cGAS–STING pathway in health and disease
- (2019) Mona Motwani et al. NATURE REVIEWS GENETICS
- Mitophagy in Parkinson’s Disease: From Pathogenesis to Treatment
- (2019) Jia Liu et al. Cells
- GBA1-associated parkinsonism
- (2019) Emory Ryan et al. CURRENT OPINION IN NEUROLOGY
- Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2
- (2019) Yvette C. Wong et al. DEVELOPMENTAL CELL
- ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
- (2019) Chun-Yan Lim et al. NATURE CELL BIOLOGY
- DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives
- (2019) Mariaelena Repici et al. Journal of Clinical Medicine
- Parkinson disease
- (2019) R. Balestrino et al. EUROPEAN JOURNAL OF NEUROLOGY
- DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1
- (2019) Yi Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration
- (2019) Cláudia M. Deus et al. TRENDS IN MOLECULAR MEDICINE
- Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
- (2019) Souvik Modi et al. Nature Communications
- NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
- (2019) D. Höglinger et al. Nature Communications
- LRRK 2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK ‐mediated ubiquitination pathway
- (2019) Toshihiko Toyofuku et al. EMBO JOURNAL
- The ‘mitochondrial contact site and cristae organising system’ (MICOS) in health and human disease
- (2019) Matthew J Eramo et al. JOURNAL OF BIOCHEMISTRY
- Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
- (2019) Michael X. Henderson et al. NEURON
- TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
- (2019) A. Scotto Rosato et al. Nature Communications
- Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease
- (2019) Juan Garrido-Maraver et al. Biology Open
- Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson’s Disease Patients
- (2019) Clara Berenguer-Escuder et al. Journal of Clinical Medicine
- Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites
- (2018) Ayelén González Montoro et al. DEVELOPMENTAL CELL
- A brain-enriched Drp1 isoform associates with lysosomes, late endosomes and the plasma membrane
- (2018) Kie Itoh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions
- (2018) Dijin Xu et al. JOURNAL OF CELL BIOLOGY
- Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites
- (2018) Björn D.M. Bean et al. JOURNAL OF CELL BIOLOGY
- Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis
- (2018) Yvette C. Wong et al. NATURE
- Building and decoding ubiquitin chains for mitophagy
- (2018) J. Wade Harper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ER–mitochondria signaling in Parkinson’s disease
- (2018) Patricia Gómez-Suaga et al. Cell Death & Disease
- Disruption of ER−mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis
- (2018) Dawn H. W. Lau et al. Cell Death & Disease
- Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP
- (2018) Yaxiong Yang et al. Nature Communications
- Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes
- (2018) Bernadette Schreiner et al. JOURNAL OF ALZHEIMERS DISEASE
- VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites
- (2018) Nikit Kumar et al. JOURNAL OF CELL BIOLOGY
- GIV/Girdin promotes cell survival during endoplasmic reticulum stress
- (2018) Peter Nguyen et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Lipid Droplets in Cancer: Guardians of Fat in a Stressful World
- (2018) Toni Petan et al. MOLECULES
- Regulation of Endoplasmic Reticulum-Mitochondria contacts by Parkin via Mfn2
- (2018) Valentina Basso et al. PHARMACOLOGICAL RESEARCH
- Membrane binding, internalization, and sorting of alpha-synuclein in the cell
- (2018) Caterina Masaracchia et al. Acta Neuropathologica Communications
- Human SEIPIN Binds Anionic Phospholipids
- (2018) Renhong Yan et al. DEVELOPMENTAL CELL
- A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers
- (2018) Andrés Norambuena et al. EMBO JOURNAL
- Cryo–electron microscopy structure of the lipid droplet–formation protein seipin
- (2018) Xuewu Sui et al. JOURNAL OF CELL BIOLOGY
- Retromer has a selective function in cargo sorting via endosome transport carriers
- (2018) Yi Cui et al. JOURNAL OF CELL BIOLOGY
- The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis
- (2018) Norbert Volkmar et al. JOURNAL OF CELL SCIENCE
- Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
- (2018) Saranna Fanning et al. MOLECULAR CELL
- Identification of a large homozygous VPS13C deletion in a patient with early-onset Parkinsonism
- (2018) Hossein Darvish et al. MOVEMENT DISORDERS
- IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes
- (2018) Peace Atakpa et al. Cell Reports
- Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease
- (2018) Christy O.Y. Hung et al. Cell Reports
- Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure
- (2017) Jędrzej Szymański et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Vps13-Mcp1 interact at vacuole–mitochondria interfaces and bypass ER–mitochondria contact sites
- (2017) Arun T. John Peter et al. JOURNAL OF CELL BIOLOGY
- The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling
- (2017) Alexander R. van Vliet et al. MOLECULAR CELL
- Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A
- (2017) Katarina Willén et al. Molecular Neurodegeneration
- Applying systems-level spectral imaging and analysis to reveal the organelle interactome
- (2017) Alex M. Valm et al. NATURE
- Crystal structures of Mmm1 and Mdm12–Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites
- (2017) Hanbin Jeong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER-mitochondria tethering by PDZD8 regulates Ca2+dynamics in mammalian neurons
- (2017) Yusuke Hirabayashi et al. SCIENCE
- Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis
- (2017) Lorena Fernández-Mosquera et al. Scientific Reports
- An Endosomal NAADP-Sensitive Two-Pore Ca 2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling
- (2017) Bethan S. Kilpatrick et al. Cell Reports
- PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?
- (2017) Dominika Truban et al. Journal of Parkinsons Disease
- Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology
- (2017) Sabrina Contino et al. Frontiers in Physiology
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy
- (2016) Suzanne Lesage et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Touché! STARD3 and STARD3NL tether the ER to endosomes
- (2016) Léa P. Wilhelm et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Erythroid cell mitochondria receive endosomal iron by a “kiss-and-run” mechanism
- (2016) Amel Hamdi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool
- (2016) Ragna Sannerud et al. CELL
- The MICOS complex of human mitochondria
- (2016) Vera Kozjak-Pavlovic CELL AND TISSUE RESEARCH
- Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca 2+ Homeostasis in Neural Stem Cell Development
- (2016) Seongsoo Lee et al. DEVELOPMENTAL CELL
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- SLC25A46is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome
- (2016) Alexandre Janer et al. EMBO Molecular Medicine
- Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex
- (2016) Hanbin Jeong et al. EMBO REPORTS
- ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function
- (2016) Romain Galmes et al. EMBO REPORTS
- The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations
- (2016) Clément A. Gautier et al. HUMAN MOLECULAR GENETICS
- Loss of Mitochondrial Function Impairs Lysosomes
- (2016) Julie Demers-Lamarche et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functions of Polyamines in Mammals
- (2016) Anthony E. Pegg JOURNAL OF BIOLOGICAL CHEMISTRY
- Endosome–mitochondria interactions are modulated by iron release from transferrin
- (2016) Anupam Das et al. JOURNAL OF CELL BIOLOGY
- Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse
- (2016) Yun Qian et al. Journal of Neuroinflammation
- The Emerging Network of Mitochondria-Organelle Contacts
- (2016) Andrew Murley et al. MOLECULAR CELL
- Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson’s Disease
- (2016) M. Rodríguez-Arribas et al. MOLECULAR NEUROBIOLOGY
- Sar1, a Novel Regulator of ER-Mitochondrial Contact Sites
- (2016) Karin B. Ackema et al. PLoS One
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry
- (2016) Benjamin Chun-Kit Tong et al. Science Signaling
- Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes
- (2016) Anna Raffaello et al. TRENDS IN BIOCHEMICAL SCIENCES
- Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease
- (2016) I Celardo et al. Cell Death & Disease
- Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP
- (2016) Emily Filichia et al. Scientific Reports
- Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2
- (2016) Riccardo Filadi et al. Cell Reports
- Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer’s Disease Mutations
- (2016) Grace Woodruff et al. Cell Reports
- Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry
- (2016) Benjamin Chun-Kit Tong et al. Science Signaling
- Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?
- (2015) Aleksandar Peric et al. ACTA NEUROPATHOLOGICA
- Calcium signaling at ER membrane contact sites
- (2015) Thomas Burgoyne et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Mdm1/Snx13 is a novel ER–endolysosomal interorganelle tethering protein
- (2015) W. Mike Henne et al. JOURNAL OF CELL BIOLOGY
- Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts
- (2015) Andrew Murley et al. JOURNAL OF CELL BIOLOGY
- ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13
- (2015) Alexander B. Lang et al. JOURNAL OF CELL BIOLOGY
- The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites
- (2015) Alexandra Grippa et al. JOURNAL OF CELL BIOLOGY
- Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
- (2015) Maria Szaruga et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Lipid partitioning at the nuclear envelope controls membrane biogenesis
- (2015) Antonio Daniel Barbosa et al. MOLECULAR BIOLOGY OF THE CELL
- Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth
- (2015) Camilla Raiborg et al. NATURE
- Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
- (2015) Wenzhang Wang et al. NATURE MEDICINE
- Impaired intracellular trafficking defines early Parkinson's disease
- (2015) Benjamin H.M. Hunn et al. TRENDS IN NEUROSCIENCES
- Lam6 Regulates the Extent of Contacts between Organelles
- (2015) Yael Elbaz-Alon et al. Cell Reports
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function
- (2015) Fu-Lei Tang et al. Cell Reports
- Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins
- (2015) Nicol Birsa et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- A Dynamic Interface between Vacuoles and Mitochondria in Yeast
- (2014) Yael Elbaz-Alon et al. DEVELOPMENTAL CELL
- Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria
- (2014) Carina Hönscher et al. DEVELOPMENTAL CELL
- Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
- (2014) Gian-Luca McLelland et al. EMBO JOURNAL
- Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function
- (2014) Laura A. Martin et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
- (2014) L. N. Hockey et al. JOURNAL OF CELL SCIENCE
- -Synuclein Is Localized to Mitochondria-Associated ER Membranes
- (2014) C. Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
- (2014) Alban Ordureau et al. MOLECULAR CELL
- VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
- (2014) Emiko Miura et al. NEUROBIOLOGY OF DISEASE
- Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease
- (2014) T. T. Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43
- (2014) Radu Stoica et al. Nature Communications
- Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity
- (2014) Xin Wang et al. Cell Reports
- A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria
- (2014) Sujoy Lahiri et al. PLOS BIOLOGY
- Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders
- (2014) Sarah van Veen et al. Frontiers in Molecular Neuroscience
- A fast growing spectrum of biological functions of γ-secretase in development and disease
- (2013) Nathalie Jurisch-Yaksi et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Toxicity of Polyamines and Their Metabolic Products
- (2013) Anthony E. Pegg CHEMICAL RESEARCH IN TOXICOLOGY
- Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis
- (2013) T. Tan et al. JOURNAL OF CELL SCIENCE
- STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER
- (2013) F. Alpy et al. JOURNAL OF CELL SCIENCE
- The Expression of Neuronal Sorting Nexin 8 (SNX8) Exacerbates Abnormal Cholesterol Levels
- (2013) Gillian Muirhead et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Neuroprotective Function of DJ-1 in Parkinson’s Disease
- (2013) Hiroyoshi Ariga et al. Oxidative Medicine and Cellular Longevity
- -Synuclein in Parkinson's Disease
- (2013) L. Stefanis Cold Spring Harbor Perspectives in Medicine
- PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
- (2012) T Verfaillie et al. CELL DEATH AND DIFFERENTIATION
- Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
- (2012) Estela Area-Gomez et al. EMBO JOURNAL
- α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions
- (2012) Tito Calì et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels
- (2012) Dustin Shilling et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
- (2012) Katrijn Coen et al. JOURNAL OF CELL BIOLOGY
- A conserved membrane-binding domain targets proteins to organelle contact sites
- (2012) A. Toulmay et al. JOURNAL OF CELL SCIENCE
- Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1
- (2012) Barry E. Kennedy et al. JOURNAL OF LIPID RESEARCH
- Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease
- (2012) Weilin Xie et al. JOURNAL OF NEUROCHEMISTRY
- A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2
- (2012) X. Zhang et al. JOURNAL OF NEUROSCIENCE
- Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
- (2012) Yonghao Zhao et al. Molecular Neurodegeneration
- ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome
- (2012) Anne Grünewald et al. NEUROBIOLOGY OF AGING
- Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study
- (2012) Pierre Cosson et al. PLoS One
- Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
- (2012) B. Dehay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Membrane Trafficking Pathways in Alzheimer's Disease
- (2012) Lawrence Rajendran et al. TRAFFIC
- Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
- (2012) Song Liu et al. PLoS Genetics
- Rotenone, Paraquat, and Parkinson’s Disease
- (2011) Caroline M. Tanner et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
- (2011) Kurt J. De Vos et al. HUMAN MOLECULAR GENETICS
- Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
- (2011) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore
- (2011) Omar Nelson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking
- (2011) Ximing Du et al. JOURNAL OF CELL BIOLOGY
- Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae
- (2011) N. Jacquier et al. JOURNAL OF CELL SCIENCE
- Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
- (2011) Hong Wang et al. JOURNAL OF LIPID RESEARCH
- Composition and Topology of the Endoplasmic Reticulum–Mitochondria Encounter Structure
- (2011) David A. Stroud et al. JOURNAL OF MOLECULAR BIOLOGY
- Linking lipids to Alzheimer's disease: cholesterol and beyond
- (2011) Gilbert Di Paolo et al. NATURE REVIEWS NEUROSCIENCE
- ATP13A2 regulates mitochondrial bioenergetics through macroautophagy
- (2011) Aaron M. Gusdon et al. NEUROBIOLOGY OF DISEASE
- ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
- (2011) R. Sannerud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections
- (2011) B. Kornmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER Tubules Mark Sites of Mitochondrial Division
- (2011) J. R. Friedman et al. SCIENCE
- Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease
- (2010) Gunnar K. Gouras et al. ACTA NEUROPATHOLOGICA
- Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction
- (2010) Ryota Iwasawa et al. EMBO JOURNAL
- Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40
- (2010) Koji Yamano et al. EMBO REPORTS
- Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing
- (2010) Hirokazu Okada et al. FASEB JOURNAL
- Tom7 Regulates Mdm10-mediated Assembly of the Mitochondrial Import Channel Protein Tom40
- (2010) Koji Yamano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biogenesis of Mitochondria: Dual Role of Tom7 in Modulating Assembly of the Preprotein Translocase of the Outer Membrane
- (2010) Thomas Becker et al. JOURNAL OF MOLECULAR BIOLOGY
- Macroautophagy is defective in mucolipin-1-deficient mouse neurons
- (2010) Cyntia Curcio-Morelli et al. NEUROBIOLOGY OF DISEASE
- Niemann-Pick disease type C
- (2010) Marie T Vanier Orphanet Journal of Rare Diseases
- Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons
- (2010) K.-H. Cheung et al. Science Signaling
- Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria
- (2009) Estela Area-Gomez et al. AMERICAN JOURNAL OF PATHOLOGY
- Polyamines: Potential anti-inflammatory agents and their possible mechanism of action
- (2009) SureshRamnath Naik et al. INDIAN JOURNAL OF PHARMACOLOGY
- Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning
- (2009) Nuno Rocha et al. JOURNAL OF CELL BIOLOGY
- Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
- (2009) Lucia Brunello et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein
- (2009) Mark Charman et al. JOURNAL OF LIPID RESEARCH
- -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment
- (2009) M. Takami et al. JOURNAL OF NEUROSCIENCE
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
- (2009) Benoît Kornmann et al. SCIENCE
- A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein
- (2008) Susanne Schöbel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes
- (2008) Jiyeon Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
- (2008) Weihua Fei et al. JOURNAL OF CELL BIOLOGY
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
- Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
- (2008) S. Hauptmann et al. NEUROBIOLOGY OF AGING
- Trafficking, a key player in regulated intramembrane proteolysis
- (2008) Ragna Sannerud et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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