Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER

(2017) Muthukumar Kannan et al.   JOURNAL OF LIPID RESEARCH

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

(2017) Kurt J. De Vos et al.   NEUROBIOLOGY OF DISEASE

Piecing Together the Patchwork of Contact Sites

(2017) Alberto T. Gatta et al.   TRENDS IN CELL BIOLOGY

TBK1: a new player in ALS linking autophagy and neuroinflammation

(2017) James A. Oakes et al.   Molecular Brain

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation

(2017) Victoria Hung et al.   eLife

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

(2017) Christopher P. Webster et al.   Frontiers in Molecular Neuroscience

Altered Cholesterol Ester Cycle in Skin Fibroblasts from Patients with Alzheimer's Disease

(2017) Alessandra Pani et al.   JOURNAL OF ALZHEIMERS DISEASE

Arbitrary-Region Raster Image Correlation Spectroscopy

(2016) Jelle Hendrix et al.   BIOPHYSICAL JOURNAL

Spatiotemporal Fluctuation Analysis: A Powerful Tool for the Future Nanoscopy of Molecular Processes

(2016) Carmine Di Rienzo et al.   BIOPHYSICAL JOURNAL

Mitochondrial lipids in neurodegeneration

(2016) Andreas Aufschnaiter et al.   CELL AND TISSUE RESEARCH

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria-associated ER membranes and Alzheimer disease

(2016) Estela Area-Gomez et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1 ‐ and SOD1 ‐linked ALS

(2016) Seiji Watanabe et al.   EMBO Molecular Medicine

FATE1 antagonizes calcium‐ and drug‐induced apoptosis by uncoupling ER and mitochondria

(2016) Mabrouka Doghman‐Bouguerra et al.   EMBO REPORTS

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

(2016) Radu Stoica et al.   EMBO REPORTS

Neuronal overexpression of human VAPB slows motor impairment and neuromuscular denervation in a mouse model of ALS

(2016) Ji-Yoen Kim et al.   HUMAN MOLECULAR GENETICS

Metabolic signaling functions of ER–mitochondria contact sites: role in metabolic diseases

(2016) Emily Tubbs et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

(2016) Giampaolo Morciano et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis

(2016) Giovanni Manfredi et al.   NEUROBIOLOGY OF DISEASE

Sar1, a Novel Regulator of ER-Mitochondrial Contact Sites

(2016) Karin B. Ackema et al.   PLoS One

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Two-colour live-cell nanoscale imaging of intracellular targets

(2016) Francesca Bottanelli et al.   Nature Communications

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

(2016) Aleix Sala-Vila et al.   Scientific Reports

Motion of nanoprobes in complex liquids within the framework of the length-scale dependent viscosity model

(2015) Tomasz Kalwarczyk et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids

(2015) Justyna Janikiewicz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration

(2015) Nathalie Bernard-Marissal et al.   BRAIN

The mitochondria–plasma membrane contact site

(2015) Benedikt Westermann   CURRENT OPINION IN CELL BIOLOGY

ApoE4 upregulates the activity of mitochondria-associated ER membranes

(2015) M. D. Tambini et al.   EMBO REPORTS

Mitochondria-Associated Membrane Formation in Hormone-Stimulated Leydig Cell Steroidogenesis: Role of ATAD3

(2015) Leeyah Issop et al.   ENDOCRINOLOGY

Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells

(2015) K. D. Elgass et al.   JOURNAL OF CELL SCIENCE

Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

(2015) Justyna Janikiewicz et al.   JOURNAL OF LIPID RESEARCH

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

(2015) Carlotta Giorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations

(2015) Hong Qi et al.   Scientific Reports

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

(2015) Carlotta Giorgi et al.   Oncotarget

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

At the right distance: ER-mitochondria juxtaposition in cell life and death

(2014) Deborah Naon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria versus endoplasmic reticulum

(2014) Haidar Akl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Dynamic Interface between Vacuoles and Mitochondria in Yeast

(2014) Yael Elbaz-Alon et al.   DEVELOPMENTAL CELL

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction

(2014) Manoj Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Oncogenic K-Ras suppresses IP3-dependent Ca2+ release through remodelling of the isoform composition of IP3Rs and ER luminal Ca2+ levels in colorectal cancer cell lines

(2014) C. Pierro et al.   JOURNAL OF CELL SCIENCE

Abnormal Intracellular Calcium Signaling and SNARE-Dependent Exocytosis Contributes to SOD1G93A Astrocyte-Mediated Toxicity in Amyotrophic Lateral Sclerosis

(2014) H. Kawamata et al.   JOURNAL OF NEUROSCIENCE

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Isolation of plasma membrane–associated membranes from rat liver

(2014) Jan M Suski et al.   Nature Protocols

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

(2014) M Bonora et al.   ONCOGENE

Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances

(2014) J T Vollrath et al.   Cell Death & Disease

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

The molecular hug between the ER and the mitochondria

(2013) Benoît Kornmann   CURRENT OPINION IN CELL BIOLOGY

Exercise-induced heart mitochondrial cholesterol depletion influences the inhibition of mitochondrial swelling

(2013) Wieslaw Ziolkowski et al.   EXPERIMENTAL PHYSIOLOGY

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

(2013) J. Prause et al.   HUMAN MOLECULAR GENETICS

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM)

(2013) Chloe N. Poston et al.   Journal of Proteomics

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling

(2013) A Rimessi et al.   ONCOGENE

Mitochondria Localize to the Cleavage Furrow in Mammalian Cytokinesis

(2013) Elizabeth J. Lawrence et al.   PLoS One

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria

(2013) L. L. Lackner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Import of phosphatidylserine to and export of phosphatidylethanolamine molecular species from mitochondria

(2012) Ville Kainu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosis resistance and Ca2+ homeostasis

(2012) Colins O. Eno et al.   MOLECULAR BIOLOGY OF THE CELL

Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis

(2012) S Marchi et al.   Cell Death & Disease

Dimerization-Dependent Green and Yellow Fluorescent Proteins

(2012) Spencer C. Alford et al.   ACS Synthetic Biology

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria

(2011) Michiko Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of PML in the control of apoptotic cell fate: a new key player at ER–mitochondria sites

(2011) P Pinton et al.   CELL DEATH AND DIFFERENTIATION

VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria

(2011) D De Stefani et al.   CELL DEATH AND DIFFERENTIATION

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

(2011) Emily M Lynes et al.   EMBO JOURNAL

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Stearoyl-CoA desaturase and insulin signaling — What is the molecular switch?

(2010) Pawel Dobrzyn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

p66Shc—a longevity redox protein in human prostate cancer progression and metastasis

(2010) Mythilypriya Rajendran et al.   CANCER AND METASTASIS REVIEWS

Methyl-beta-cyclodextrin induces mitochondrial cholesterol depletion and alters the mitochondrial structure and bioenergetics

(2010) Wieslaw Ziolkowski et al.   FEBS LETTERS

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone

(2010) Sara K. Custer et al.   HUMAN MOLECULAR GENETICS

Identification and Characterization of Murine Mitochondria-associated Neutral Sphingomyelinase (MA-nSMase), the Mammalian Sphingomyelin Phosphodiesterase 5

(2010) Bill X. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules

(2010) Jonathan R. Friedman et al.   JOURNAL OF CELL BIOLOGY

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?

(2010) Bo Su et al.   MOLECULAR NEUROBIOLOGY

Detergent-Resistant Microdomains Determine the Localization of  -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

(2010) T. Hayashi et al.   MOLECULAR PHARMACOLOGY

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

(2010) T.A. Mavlyutov et al.   NEUROSCIENCE

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

(2009) M. Lebiedzinska et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress

(2009) Jędrzej Szymański et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Plasma membrane associated membranes (PAM) from Jurkat cells contain STIM1 protein

(2009) Katarzyna Kozieł et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

(2009) Carlotta Giorgi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles

(2009) Magdalena Lebiedzinska et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor  B

(2009) J. Meunier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mitochondrial Ubiquitin Ligase MITOL Ubiquitinates Mutant SOD1 and Attenuates Mutant SOD1-induced Reactive Oxygen Species Generation

(2009) Ryo Yonashiro et al.   MOLECULAR BIOLOGY OF THE CELL

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

(2008) Saverio Marchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria

(2008) Scot J. Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord

(2008) Georgia Anagnostou et al.   NEUROBIOLOGY OF AGING

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

(2008) T. Szado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE