Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1
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Title
Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 32, Pages 19266-19275
Publisher
Proceedings of the National Academy of Sciences
Online
2020-07-24
DOI
10.1073/pnas.2003236117
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Note: Only part of the references are listed.- Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases
- (2020) Giorgio Santoni et al. Frontiers in Physiology
- Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
- (2019) Jean-Michel Cioni et al. CELL
- Lysosomal storage disorders – challenges, concepts and avenues for therapy: beyond rare diseases
- (2019) André R. A. Marques et al. JOURNAL OF CELL SCIENCE
- The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
- (2019) Charles B Phillips et al. eLife
- Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis
- (2019) Yvette C. Wong et al. TRENDS IN CELL BIOLOGY
- Increased lysosomal exocytosis induced by lysosomal Ca2+ channel agonists protects human dopaminergic neurons from α-synuclein toxicity
- (2019) Taiji Tsunemi et al. JOURNAL OF NEUROSCIENCE
- Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
- (2019) Wesley Peng et al. Neurotherapeutics
- The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance
- (2019) Valentina Tedeschi et al. Scientific Reports
- RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
- (2019) Ya-Cheng Liao et al. CELL
- Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2
- (2019) Yvette C. Wong et al. DEVELOPMENTAL CELL
- ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
- (2019) Chun-Yan Lim et al. NATURE CELL BIOLOGY
- IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
- (2019) Adam Bartok et al. Nature Communications
- NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
- (2019) D. Höglinger et al. Nature Communications
- Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
- (2019) Taylor F. Minckley et al. Nature Communications
- TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
- (2019) A. Scotto Rosato et al. Nature Communications
- TRPML1: The Ca (2+) retaker of the lysosome
- (2018) Simone Di Paola et al. CELL CALCIUM
- Calcium signaling and molecular mechanisms underlying neurodegenerative diseases
- (2018) Ekaterina Pchitskaya et al. CELL CALCIUM
- Calcium Signaling and Reactive Oxygen Species in Mitochondria
- (2018) Edoardo Bertero et al. CIRCULATION RESEARCH
- A brain-enriched Drp1 isoform associates with lysosomes, late endosomes and the plasma membrane
- (2018) Kie Itoh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis
- (2018) Yvette C. Wong et al. NATURE
- Lysosome trafficking and signaling in health and neurodegenerative diseases
- (2018) Pearl P.Y. Lie et al. NEUROBIOLOGY OF DISEASE
- ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease
- (2018) Jorge S. Valadas et al. NEURON
- Single organelle dynamics linked to 3D structure by correlative live-cell imaging and 3D electron microscopy
- (2018) Job Fermie et al. TRAFFIC
- The machineries, regulation and cellular functions of mitochondrial calcium
- (2018) Carlotta Giorgi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models
- (2018) Kyu-Sun Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore
- (2018) Qixin Chen et al. Small
- Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales
- (2018) Yuting Guo et al. CELL
- The lysosome as a cellular centre for signalling, metabolism and quality control
- (2018) Rosalie E. Lawrence et al. NATURE CELL BIOLOGY
- Structural basis for PtdInsP2-mediated human TRPML1 regulation
- (2018) Michael Fine et al. Nature Communications
- Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia
- (2017) Rachel Allison et al. JOURNAL OF CELL BIOLOGY
- Human TRPML1 channel structures in open and closed conformations
- (2017) Philip Schmiege et al. NATURE
- Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
- (2017) Marscha Hirschi et al. NATURE
- Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
- (2017) Qingfeng Chen et al. NATURE
- Applying systems-level spectral imaging and analysis to reveal the organelle interactome
- (2017) Alex M. Valm et al. NATURE
- Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel
- (2017) Minghui Li et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture
- (2017) Thomas Misgeld et al. NEURON
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- ER-mitochondria tethering by PDZD8 regulates Ca2+dynamics in mammalian neurons
- (2017) Yusuke Hirabayashi et al. SCIENCE
- Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders
- (2017) Nicoletta Plotegher et al. TRENDS IN MOLECULAR MEDICINE
- Cell-permeable organic fluorescent probes for live-cell long-term super-resolution imaging reveal lysosome-mitochondrion interactions
- (2017) Yubing Han et al. Nature Communications
- Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel
- (2017) Minghui Li et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart
- (2017) Daniel Aston et al. Scientific Reports
- VDAC2-specific cellular functions and the underlying structure
- (2016) Shamim Naghdi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+release and Ca2+influx
- (2016) Bethan S. Kilpatrick et al. JOURNAL OF CELL SCIENCE
- Defects in trafficking bridge Parkinson's disease pathology and genetics
- (2016) Asa Abeliovich et al. NATURE
- A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
- (2016) Xinran Li et al. NATURE CELL BIOLOGY
- MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
- (2016) Xiaoli Zhang et al. Nature Communications
- The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
- (2016) Abigail G Garrity et al. eLife
- Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts
- (2015) Bei-Bei Chu et al. CELL
- Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV
- (2015) Soonhong Park et al. EMBO REPORTS
- Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
- (2015) Diego L. Medina et al. NATURE CELL BIOLOGY
- Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
- (2015) Wuyang Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Phosphoinositide-Gated Lysosomal Ca2+Channel, TRPML1, Is Required for Phagosome Maturation
- (2015) Roya M. Dayam et al. TRAFFIC
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- Activation of TRPML1 Clears Intraneuronal A in Preclinical Models of HIV Infection
- (2014) M. Bae et al. JOURNAL OF NEUROSCIENCE
- The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy
- (2014) Xiping Cheng et al. NATURE MEDICINE
- Disturbed mitochondrial dynamics and neurodegenerative disorders
- (2014) Florence Burté et al. Nature Reviews Neurology
- A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
- (2014) Cheng-Chang Chen et al. Nature Communications
- Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy
- (2014) Koji Yamano et al. eLife
- Improved Orange and Red Ca2+ Indicators and Photophysical Considerations for Optogenetic Applications
- (2013) Jiahui Wu et al. ACS Chemical Neuroscience
- A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
- (2013) Mohammad Samie et al. DEVELOPMENTAL CELL
- Systematic Screens for Proteins That Interact with the Mucolipidosis Type IV Protein TRPML1
- (2013) Ellen Spooner et al. PLoS One
- Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake
- (2013) S. Feng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca2+transfer from the sarcoplasmic reticulum to the mitochondria in the heart
- (2012) Choon Kee Min et al. BIOCHEMICAL JOURNAL
- Regulation of ATP production by mitochondrial Ca2+
- (2012) Andrei I. Tarasov et al. CELL CALCIUM
- Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
- (2012) Dongbiao Shen et al. Nature Communications
- Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P2 phosphatase FIG4
- (2011) Garth Nicholson et al. BRAIN
- Voltage-dependent anion channel 2 modulates resting Ca2+ sparks, but not action potential-induced Ca2+ signaling in cardiac myocytes
- (2011) Krishna Prasad Subedi et al. CELL CALCIUM
- Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
- (2011) Joshua M. Baughman et al. NATURE
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
- (2011) Diego De Stefani et al. NATURE
- Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons
- (2011) K. T. Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels
- (2010) Shin-Young Ryu et al. FEBS LETTERS
- Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel
- (2010) Jonathan L. Eichelsdoerfer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
- (2010) Xian-ping Dong et al. Nature Communications
- Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS
- (2009) Clement Y. Chow et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Chaperone-mediated autophagy is defective in mucolipidosis type IV
- (2009) Bhuvarahamurthy Venugopal et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter
- (2009) D. Jiang et al. SCIENCE
- Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration
- (2008) Xuebao Zhang et al. BRAIN
- Autophagic dysfunction in mucolipidosis type IV patients
- (2008) Silvia Vergarajauregui et al. HUMAN MOLECULAR GENETICS
- The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
- (2008) Xian-Ping Dong et al. NATURE
- Mapping the ruthenium red-binding site of the voltage-dependent anion channel-1
- (2007) Adrian Israelson et al. CELL CALCIUM
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