Journal
FRONTIERS IN MOLECULAR NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.734273
Keywords
Parkinson's disease; IPSC; mitophagy; risk; Miro1
Categories
Funding
- Michael J. Fox Foundation (MJFF) [18195]
- MJFF
- Abbvie
- Avid
- Biogen
- Bristol-Myers Squibb
- COVANCE
- GE Healthcare
- Genentech
- GlaxoSmithKline
- Lilly
- Lundbeck
- Merck
- Meso Scale Discovery
- Pfizer
- Piramal
- Roche
- Servier
- UCB
- Stanford WHSDM Center
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The study identified the mitochondrial protein Miro1 as potentially a molecular marker for Parkinson's disease and at-risk individuals. The response of Miro1 to mitochondrial depolarization was significantly associated with PD risk, suggesting its potential use for detecting both PD and at-risk populations. Tracking the Miro1 marker could assist in diagnosis and Miro1-based drug discoveries.
There is a lack of reliable molecular markers for Parkinson's disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease onset. We have previously found that the mitochondrial protein Miro1 is resistant to mitochondrial depolarization-induced degradation in fibroblasts from a large number of PD patients and several at-risk individuals. Therefore, Miro1 has the potential to molecularly label PD populations. In order to determine whether Miro1 could serve as a molecular marker for the risk of PD, here we examine the Miro1 response to mitochondrial depolarization by biochemical approaches in induced pluripotent stem cells from a cohort of at-risk individuals. Our results show that the Miro1 phenotype is significantly associated with PD risk. We propose that Miro1 is a promising molecular marker for detecting both PD and at-risk populations. Tracking this Miro1 marker could aid in diagnosis and Miro1-based drug discoveries.
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