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Title
Targeting mitophagy in Parkinson's disease
Authors
Keywords
biomarker, Parkinson’s disease, mitochondria, mitophagy, drug discovery, PINK1, Parkin
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume -, Issue -, Pages 100209
Publisher
Elsevier BV
Online
2020-12-24
DOI
10.1074/jbc.rev120.014294
References
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- Kinetin Improves IKBKAP mRNA Splicing in Patients With Familial Dysautonomia
- (2011) Felicia B Axelrod et al. PEDIATRIC RESEARCH
- Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
- (2011) F. H. Sterky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multinuclear Magnetic Resonance Spectroscopy for in Vivo Assessment of Mitochondrial Dysfunction in Parkinson's Disease
- (2010) Claire Henchcliffe et al. Annals of the New York Academy of Sciences
- Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
- (2010) I. Irrcher et al. HUMAN MOLECULAR GENETICS
- DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
- (2010) Kelly Jean Thomas et al. HUMAN MOLECULAR GENETICS
- Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
- (2010) Seok Min Jin et al. JOURNAL OF CELL BIOLOGY
- Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
- (2010) Jaime N. Guzman et al. NATURE
- Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2
- (2010) H. Mortiboys et al. NEUROLOGY
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson’s disease
- (2010) Masaaki Hirayama et al. PARKINSONISM & RELATED DISORDERS
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
- (2010) H. S. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease
- (2009) Elke Hattingen et al. BRAIN
- MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease
- (2009) D. Galter et al. GENES BRAIN AND BEHAVIOR
- Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant -Synuclein
- (2009) X.-H. Lu et al. JOURNAL OF NEUROSCIENCE
- 8-OHdG in Cerebrospinal Fluid as a Marker of Oxidative Stress in Various Neurodegenerative Diseases
- (2009) K. Gmitterová et al. Neurodegenerative Diseases
- Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients
- (2009) Yoshiro Saito et al. NEUROSCIENCE LETTERS
- Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process
- (2009) Chiaki Isobe et al. NEUROSCIENCE LETTERS
- Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy
- (2008) Shane E. Kruse et al. Cell Metabolism
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
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