Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Vacuolar H+-ATPase subunits Voa1 and Voa2 cooperatively regulate secretory vesicle acidification, transmitter uptake, and storage

(2011) Ner Mu Nar Saw et al.   MOLECULAR BIOLOGY OF THE CELL

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes

(2011) D. B. Thimiri Govinda Raj et al.   Molecular Systems Biology

A Weak Base-Generating System Suitable for Selective Manipulation of Lysosomal pH

(2011) Luciene R. Carraro-Lacroix et al.   TRAFFIC

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Regulation and Isoform Function of the V-ATPases

(2010) Masashi Toei et al.   BIOCHEMISTRY

Alzheimer's Disease Neurons Fail the Acid Test

(2010) Wim Annaert et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism inDrosophila melanogasterphotoreceptors

(2010) W. Ryan Williamson et al.   JOURNAL OF CELL BIOLOGY

Highly Efficient Multicistronic Lentiviral Vectors with Peptide 2A Sequences

(2009) Abdelilah Ibrahimi et al.   HUMAN GENE THERAPY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE