Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association
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Title
Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association
Authors
Keywords
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Journal
Biomolecules
Volume 11, Issue 9, Pages 1333
Publisher
MDPI AG
Online
2021-09-10
DOI
10.3390/biom11091333
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Note: Only part of the references are listed.- Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes
- (2021) Leif Antonschmidt et al. Science Advances
- α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
- (2021) Aysegul Dilsizoglu Senol et al. PLOS BIOLOGY
- A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research
- (2020) Senthil T. Kumar et al. JOURNAL OF NEUROCHEMISTRY
- LRRK2 in Parkinson disease: challenges of clinical trials
- (2020) Eduardo Tolosa et al. Nature Reviews Neurology
- The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
- (2020) Anne-Laure Mahul-Mellier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vesicle trafficking and lipid metabolism in synucleinopathy
- (2020) Saranna Fanning et al. ACTA NEUROPATHOLOGICA
- Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports
- (2020) Hilal A. Lashuel NEUROBIOLOGY OF DISEASE
- The proline-rich domain promotes Tau liquid–liquid phase separation in cells
- (2020) Xuemei Zhang et al. JOURNAL OF CELL BIOLOGY
- LRRK2 and the Endolysosomal System in Parkinson’s Disease
- (2020) Madalynn L. Erb et al. Journal of Parkinsons Disease
- Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease
- (2019) Angelique di Domenico et al. Stem Cell Reports
- α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling
- (2019) Mingzhu Huang et al. Frontiers in Neuroscience
- Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose
- (2019) Anna-Carin Hoffmann et al. Scientific Reports
- Parkinson’s disease GWAS-linked Park16 carriers show greater motor progression
- (2019) Xiao Deng et al. JOURNAL OF MEDICAL GENETICS
- DNAJC proteins and pathways to parkinsonism
- (2019) Dorien A. Roosen et al. FEBS Journal
- Dysfunction of Cellular Proteostasis in Parkinson’s Disease
- (2019) Šárka Lehtonen et al. Frontiers in Neuroscience
- GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic Approaches
- (2019) Giulietta M. Riboldi et al. Cells
- Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1–assisted dopamine transporter endocytosis
- (2019) Junpei Kobayashi et al. FASEB JOURNAL
- Role of the endolysosomal system in Parkinson’s disease
- (2019) D. J. Vidyadhara et al. JOURNAL OF NEUROCHEMISTRY
- The physiological role of α‐synuclein and its relationship to Parkinson’s Disease
- (2019) David Sulzer et al. JOURNAL OF NEUROCHEMISTRY
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease
- (2019) Lena F. Burbulla et al. Science Translational Medicine
- Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein
- (2019) Leah K. Cuddy et al. NEURON
- The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human
- (2018) Rafeeq Mir et al. BIOCHEMICAL JOURNAL
- Rab GTPases and Membrane Trafficking in Neurodegeneration
- (2018) Ferdi Ridvan Kiral et al. CURRENT BIOLOGY
- Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
- (2018) Ga Ram Jeong et al. Molecular Neurodegeneration
- Internalization, axonal transport and release of fibrillar forms of alpha-synuclein
- (2018) Gregor Bieri et al. NEUROBIOLOGY OF DISEASE
- Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide
- (2018) Friederike Zunke et al. NEURON
- Rab GTPase Function in Endosome and Lysosome Biogenesis
- (2018) Lars Langemeyer et al. TRENDS IN CELL BIOLOGY
- Alteration of endosomal trafficking is associated with early-onset parkinsonism caused by SYNJ1 mutations
- (2018) Dominga Fasano et al. Cell Death & Disease
- Import and Export of Misfolded α-Synuclein
- (2018) Lilia Rodriguez et al. Frontiers in Neuroscience
- Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies
- (2017) Richard J. Karpowicz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease
- (2017) Yumiko V. Taguchi et al. JOURNAL OF NEUROSCIENCE
- Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
- (2017) Zhentao Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Association between PARK16 and Parkinson’s disease: A meta-analysis
- (2017) Tao He et al. NEUROSCIENCE LETTERS
- Rab GTPases: The Key Players in the Molecular Pathway of Parkinson’s Disease
- (2017) Meng-meng Shi et al. Frontiers in Cellular Neuroscience
- Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
- (2017) Zhentao Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- VPS35, the Retromer Complex and Parkinson’s Disease
- (2017) Erin T. Williams et al. Journal of Parkinsons Disease
- Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
- (2017) Martin Steger et al. eLife
- In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons
- (2017) Chee Yeun Chung et al. Cell Systems
- Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
- (2017) Jennifer Ngolab et al. Acta Neuropathologica Communications
- Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
- (2016) Michel Brahic et al. ACTA NEUROPATHOLOGICA
- D NAJC 6 Mutations Associated With Early-Onset Parkinson's Disease
- (2016) Simone Olgiati et al. ANNALS OF NEUROLOGY
- Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
- (2016) Saïda Abounit et al. EMBO JOURNAL
- The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation
- (2016) Airi Tarutani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation
- (2016) Jordan Follett et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology
- (2016) Amanda N. Sacino et al. JOURNAL OF NEUROCHEMISTRY
- Activation of -Glucocerebrosidase Reduces Pathological -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
- (2016) J. R. Mazzulli et al. JOURNAL OF NEUROSCIENCE
- Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges
- (2016) Lauren R. Kett et al. MOVEMENT DISORDERS
- Defects in trafficking bridge Parkinson's disease pathology and genetics
- (2016) Asa Abeliovich et al. NATURE
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of synaptic vesicle assembly promoted by α-synuclein
- (2016) Giuliana Fusco et al. Nature Communications
- Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of Disease
- (2016) Stefano Gambardella et al. Frontiers in Neuroscience
- Toxic species in amyloid disorders: Oligomers or mature fibrils
- (2015) Vibha Taneja et al. Annals of Indian Academy of Neurology
- Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations
- (2015) Roy N. Alcalay et al. BRAIN
- VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
- (2015) F.-L. Tang et al. JOURNAL OF NEUROSCIENCE
- Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
- (2015) Nripesh Dhungel et al. NEURON
- Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and -synuclein
- (2015) M. Goedert SCIENCE
- The small GTPase Rab11 co-localizes with -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity
- (2014) O. Chutna et al. HUMAN MOLECULAR GENETICS
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation
- (2014) David J. Busch et al. MOLECULAR BIOLOGY OF THE CELL
- Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
- (2014) Laura A. Volpicelli-Daley et al. MOLECULAR BIOLOGY OF THE CELL
- VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
- (2014) Emiko Miura et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner
- (2014) Guowei Yin et al. NEUROBIOLOGY OF DISEASE
- Identification of p.Gln858* in ATP13A2 in two EOPD patients and presentation of their clinical features
- (2014) Maryam Malakouti-Nejad et al. NEUROSCIENCE LETTERS
- The Complex Ultrastructure of the Endolysosomal System
- (2014) J. Klumperman et al. Cold Spring Harbor Perspectives in Biology
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- An Overview of Autophagy: Morphology, Mechanism, and Regulation
- (2013) Katherine R. Parzych et al. ANTIOXIDANTS & REDOX SIGNALING
- DNAJC13 mutations in Parkinson disease
- (2013) Carles Vilariño-Güell et al. HUMAN MOLECULAR GENETICS
- Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells
- (2013) Donna Crabtree et al. JOURNAL OF NEUROCHEMISTRY
- α-Synucleinopathy phenotypes
- (2013) Heather McCann et al. PARKINSONISM & RELATED DISORDERS
- The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer
- (2013) Jordan Follett et al. TRAFFIC
- Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
- (2013) Jiajie Diao et al. eLife
- Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway
- (2012) Jochen Klucken et al. Autophagy
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy
- (2012) I. Ahmed et al. JOURNAL OF NEUROSCIENCE
- Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
- (2012) Masatoshi Konno et al. Molecular Neurodegeneration
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein
- (2011) Takafumi Hasegawa et al. PLoS One
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease
- (2010) Pavan K. Auluck et al. Annual Review of Cell and Developmental Biology
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis
- (2010) James H. Soper et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein
- (2009) Wai Haung Yu et al. AMERICAN JOURNAL OF PATHOLOGY
- Rab11a and HSP90 Regulate Recycling of Extracellular -Synuclein
- (2009) J. Liu et al. JOURNAL OF NEUROSCIENCE
- Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
- (2009) Paul Saftig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
- (2009) Maria Xilouri et al. PLoS One
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
- (2009) Valerie Cullen et al. Molecular Brain
- Clearance and deposition of extracellular α-synuclein aggregates in microglia
- (2008) He-Jin Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
- Assembly-dependent endocytosis and clearance of extracellular a-synuclein
- (2008) He-Jin Lee et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
- (2008) Tereza Vogiatzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
- (2008) Marta Martinez-Vicente et al. JOURNAL OF CLINICAL INVESTIGATION
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