Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes

Astrocytes in stress accumulate lipid droplets

(2021) Tina Smolič et al.   GLIA

Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila

(2021) Lindsey D. Goodman et al.   CURRENT OPINION IN NEUROBIOLOGY

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

BRAIN LIPID PEROXIDATION AND ALZHEIMER DISEASE: SYNERGY BETWEEN THE BUTTERFIELD AND MATTSON LABORATORIES

(2020) D. Allan Butterfield   AGEING RESEARCH REVIEWS

The MUC6/AP2A2 Locus and Its Relevance to Alzheimer’s Disease: A Review

(2020) Peter T Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Association of genetic variants of ABCA1 with susceptibility to dementia: (SADEM study)

(2020) Juárez-Cedillo Teresa et al.   METABOLIC BRAIN DISEASE

Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms

(2020) Hyung-lok Chung et al.   NEURON

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

(2020) Ruinan Shen et al.   Translational Neurodegeneration

ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease

(2020) Maria Fe Lanfranco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

APOE4 impairs neuron‐astrocyte coupling of fatty acid metabolism

(2020) Guoyuan Qi et al.   Alzheimers & Dementia

Alzheimer's disease GWAS weighted by multi‐omics and endophenotypes identifies novel risk loci

(2020) Yiyi Ma et al.   Alzheimers & Dementia

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities

(2019) Alireza Nazarian et al.   Alzheimers Research & Therapy

Prediction of Alzheimer’s Disease-Associated Genes by Integration of GWAS Summary Data and Expression Data

(2019) Sicheng Hao et al.   Frontiers in Genetics

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway

(2019) Kotaro Furusawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

(2019) Zoë P. Van Acker et al.   Molecular Neurodegeneration

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

(2019) Sonia Moreno-Grau et al.   Alzheimers & Dementia

cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

(2019) Shamsideen A. Ojelade et al.   Cell Reports

Lipid peroxidation biomarkers correlation with medial temporal atrophy in early Alzheimer Disease

(2019) Carmen Peña-Bautista et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroimaging of Diseases Causing Dementia

(2019) Joseph C. Masdeu   NEUROLOGIC CLINICS

ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease

(2019) Ya-Ting Chang et al.   Alzheimers Research & Therapy

Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens

(2018) Matthew Zabel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ABCA1 rs2230805 and rs2230806 common gene variants are associated with Alzheimer’s disease

(2018) Ágnes Fehér et al.   NEUROSCIENCE LETTERS

Synaptic Vesicle Endocytosis in Different Model Systems

(2018) Quan Gan et al.   Frontiers in Cellular Neuroscience

A gene-specific T2A-GAL4 library for Drosophila

(2018) Pei-Tseng Lee et al.   eLife

Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis

(2018) Tetsuya Takeda et al.   eLife

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

(2018) Daan M. Van Den Brink et al.   PLoS Genetics

Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila

(2018) Scott Barish et al.   PLoS Genetics

Recycling the LDL receptor to combat atherosclerosis

(2018) Dyonne Vos et al.   Aging-US

Sphingolipids in the Pathogenesis of Parkinson’s Disease and Parkinsonism

(2018) Guang Lin et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dietary Modulation of Oxidative Stress in Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer’s Disease Genetics and ABCA7 Splicing

(2017) Jared B. Vasquez et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies

(2017) Mitsuru Shinohara et al.   JOURNAL OF LIPID RESEARCH

Brain aging and neurodegeneration: from a mitochondrial point of view

(2017) Amandine Grimm et al.   JOURNAL OF NEUROCHEMISTRY

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

(2017) Michele Ferrari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

(2017) Courtney Lane-Donovan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-β42 in APOE Knock-in and Knock-out Mice

(2017) Matthew J. Sharman et al.   JOURNAL OF ALZHEIMERS DISEASE

The influence of common free radicals and antioxidants on development of Alzheimer’s Disease

(2016) Karolina A. Wojtunik-Kulesza et al.   BIOMEDICINE & PHARMACOTHERAPY

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

(2016) Florent Ubelmann et al.   EMBO REPORTS

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

(2016) Anat Boehm-Cagan et al.   JOURNAL OF ALZHEIMERS DISEASE

The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity

(2016) B. J. Harrison et al.   JOURNAL OF NEUROSCIENCE

Influence of four polymorphisms in ABCA1 and PTGS2 genes on risk of Alzheimer’s disease: a meta-analysis

(2016) Qicong Chen et al.   NEUROLOGICAL SCIENCES

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

(2016) Tobi Van den Bossche et al.   NEUROLOGY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins

(2016) Anat Boehm-Cagan et al.   PLoS One

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease

(2016) Amit K. Chouhan et al.   Acta Neuropathologica Communications

Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update

(2015) Melissa A. Bradley-Whitman et al.   ARCHIVES OF TOXICOLOGY

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Lipophilicity of amyloid β-peptide 12–28 and 25–35 to unravel their ability to promote hydrophobic and electrostatic interactions

(2015) G. Ermondi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

(2015) Stacy Steinberg et al.   NATURE GENETICS

DrosophilaCentral Nervous System Glia

(2015) Marc R. Freeman   Cold Spring Harbor Perspectives in Biology

Drosophila Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake

(2015) Míriam Rodríguez-Vázquez et al.   PLoS Genetics

Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro

(2015) Anouar Hafiane et al.   PLoS One

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

(2014) Daniel M. Michaelson   Alzheimers & Dementia

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

(2014) Joanne Walsh et al.   Journal of Proteomics

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders

(2014) Diego E. Berman et al.   Neurotherapeutics

The Retromer Complex Is Required for Rhodopsin Recycling and Its Loss Leads to Photoreceptor Degeneration

(2014) Shiuan Wang et al.   PLOS BIOLOGY

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

(2013) Laurie H. Sanders et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of ABC transporters in lipid transport and human disease

(2013) Elizabeth J. Tarling et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Probing Mechanisms That Underlie Human Neurodegenerative Diseases inDrosophila

(2012) M. Jaiswal et al.   Annual Review of Genetics

A constant and similar assembly defect of mitochondrial respiratory chain complex I allows rapid identification of NDUFS4 mutations in patients with Leigh syndrome

(2012) Z. Assouline et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fatal breathing dysfunction in a mouse model of Leigh syndrome

(2012) Albert Quintana et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

(2012) Gerard M J Beaudoin et al.   Nature Protocols

Identification of Alzheimer disease-associated variants in genes that regulate retromer function

(2012) Badri N. Vardarajan et al.   NEUROBIOLOGY OF AGING

Antioxidant Pathways in Alzheimers Disease: Possibilities of Intervention

(2011) J. Vina et al.   CURRENT PHARMACEUTICAL DESIGN

Lipid peroxidation and neurodegenerative disease

(2011) Tanea T. Reed   FREE RADICAL BIOLOGY AND MEDICINE

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2011) Alex Ward et al.   NEUROEPIDEMIOLOGY

Distribution and Expression of Picalm in Alzheimer Disease

(2010) Shabnam Baig et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression

(2010) Melissa A. Bradley et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E receptors in the nervous system

(2009) Joachim Herz   CURRENT OPINION IN LIPIDOLOGY

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

(2008) Suzanne E. Wahrle et al.   JOURNAL OF CLINICAL INVESTIGATION

Engrailed Homeobox Genes Determine the Organization of Purkinje Cell Sagittal Stripe Gene Expression in the Adult Cerebellum

(2008) R. V. Sillitoe et al.   JOURNAL OF NEUROSCIENCE

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA