Overexpression of α‐synuclein inhibits mitochondrial Ca 2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction

Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles

(2020) Luis D. Bernal-Conde et al.   Frontiers in Neuroscience

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

(2019) Xinhe Wang et al.   Acta Neuropathologica Communications

The vicious cycle between α ‐synuclein aggregation and autophagic‐lysosomal dysfunction

(2019) Giovanni Bellomo et al.   MOVEMENT DISORDERS

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1

(2019) Yi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

(2019) Goutham K. Ganjam et al.   Cell Death & Disease

Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment

(2018) Jimena H. Martínez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

(2018) Cristine Betzer et al.   EMBO REPORTS

ER–mitochondria signaling in Parkinson’s disease

(2018) Patricia Gómez-Suaga et al.   Cell Death & Disease

The Close Encounter Between Alpha-Synuclein and Mitochondria

(2018) Mattia Vicario et al.   Frontiers in Neuroscience

New insights into the complex role of mitochondria in Parkinson’s disease

(2018) Anne Grünewald et al.   PROGRESS IN NEUROBIOLOGY

Autophagy impairment in Parkinson’s disease

(2017) Cansu Karabiyik et al.   Essays in Biochemistry

Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis

(2017) Adolfo Garcia Erustes et al.   JOURNAL OF NEUROSCIENCE RESEARCH

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Rapid, Specific, No-wash, Far-red Fluorogen Activation in Subcellular Compartments by Targeted Fluorogen Activating Proteins

(2015) Cheryl A. Telmer et al.   ACS Chemical Biology

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

(2015) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats

(2013) Lingling Lu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

(2013) Andreas Bender et al.   PLoS One

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY