Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

Familial Alzheimer's Disease Mutations in Presenilins: Effects on Endoplasmic Reticulum Calcium Homeostasis and Correlation with Clinical Phenotypes

(2017) Omar Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease

(2017) Charlene Supnet et al.   JOURNAL OF ALZHEIMERS DISEASE

The dysregulation of intracellular calcium in Alzheimer disease

(2010) Charlene Supnet et al.   CELL CALCIUM

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the  -Secretase

(2010) S. Takagi et al.   JOURNAL OF NEUROSCIENCE

Structural investigation of the C-terminal catalytic fragment of presenilin 1

(2010) S. Sobhanifar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase

(2008) Alexandra Tolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Presenilin: RIP and beyond

(2008) Matthew R. Hass et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structure and function of γ-secretase

(2008) Alexandra Tolia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES