Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport

Mechanisms of nonvesicular lipid transport

(2021) Karin M. Reinisch et al.   JOURNAL OF CELL BIOLOGY

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

(2021) Jingru Wang et al.   Nature Communications

Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease

(2021) Stefanie Smolders et al.   Acta Neuropathologica Communications

VPS13D promotes peroxisome biogenesis

(2021) Heather A. Baldwin et al.   JOURNAL OF CELL BIOLOGY

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

(2021) Andrés Guillén-Samander et al.   JOURNAL OF CELL BIOLOGY

A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis

(2021) Alireza Ghanbarpour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease

(2021) James L. Shen et al.   CURRENT BIOLOGY

Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis

(2020) Casey E. Hughes et al.   CELL

Peroxisomal fission is modulated by the mitochondrial Rho‐GTPases, Miro1 and Miro2

(2020) Christian Covill‐Cooke et al.   EMBO REPORTS

Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes

(2020) PeiQi Li et al.   JOURNAL OF CELL BIOLOGY

ER membranes exhibit phase behavior at sites of organelle contact

(2020) Christopher King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of VMP1 in Autophagy and ER–Membrane Contact: Potential Implications in Neurodegenerative Disorders

(2020) Panpan Wang et al.   Frontiers in Molecular Neuroscience

Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy

(2020) Shuliang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery

(2020) Carlos M. Guardia et al.   Cell Reports

Vps13 is required for timely removal of nurse cell corpses

(2020) Anita I. E. Faber et al.   DEVELOPMENT

XK is a partner for VPS13A: a molecular link between Chorea-Acanthocytosis and McLeod Syndrome

(2020) Jae-Sook Park et al.   MOLECULAR BIOLOGY OF THE CELL

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

(2020) Kazuaki Matoba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Familial dementia with Lewy bodies with VPS13C mutations

(2020) Ryota Kobayashi et al.   PARKINSONISM & RELATED DISORDERS

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

(2019) Takuo Osawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ratcheting up lipopolysaccharide transport

(2019) Russell E. Bishop   NATURE

Structural basis of unidirectional export of lipopolysaccharide to the cell surface

(2019) Tristan W. Owens et al.   NATURE

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

(2019) Christopher J. Shoemaker et al.   PLOS BIOLOGY

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

(2019) Wondwossen M Yeshaw et al.   eLife

Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking

(2019) Romain Da Costa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A programmable DNA-origami platform for studying lipid transfer between bilayers

(2019) Xin Bian et al.   Nature Chemical Biology

SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors

(2019) Seiichi Koike et al.   Nature Communications

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

(2019) Alison K Gillingham et al.   eLife

Lipid Dynamics at Contact Sites Between the Endoplasmic Reticulum and Other Organelles

(2019) Tamas Balla et al.   Annual Review of Cell and Developmental Biology

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece

(2018) Omi Nagata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic risk factors in Parkinson’s disease

(2018) K. J. Billingsley et al.   CELL AND TISSUE RESEARCH

Diagnostic exome sequencing in early-onset Parkinson's disease confirms VPS13C as a rare cause of autosomal-recessive Parkinson's disease

(2018) B. Schormair et al.   CLINICAL GENETICS

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

(2018) Allyson L. Anding et al.   CURRENT BIOLOGY

Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites

(2018) Ayelén González Montoro et al.   DEVELOPMENTAL CELL

Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites

(2018) Björn D.M. Bean et al.   JOURNAL OF CELL BIOLOGY

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes

(2018) Inês G. Castro et al.   TRAFFIC

Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes

(2018) Vanesa D. Ramseyer et al.   Molecular Metabolism

Genome-wide CRISPR screen identifiesTMEM41Bas a gene required for autophagosome formation

(2018) Keigo Morita et al.   JOURNAL OF CELL BIOLOGY

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organelle contact zones as sites for lipid transfer

(2018) Yasushi Tamura et al.   JOURNAL OF BIOCHEMISTRY

Identification of a large homozygous VPS13C deletion in a patient with early-onset Parkinsonism

(2018) Hossein Darvish et al.   MOVEMENT DISORDERS

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

(2018) Louise H. Wong et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Current state of knowledge in Chorea-Acanthocytosis as core Neuroacanthocytosis syndrome

(2017) Kevin Peikert et al.   European Journal of Medical Genetics

Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate

(2017) Weronika Rzepnikowska et al.   HUMAN MOLECULAR GENETICS

Vps13-Mcp1 interact at vacuole–mitochondria interfaces and bypass ER–mitochondria contact sites

(2017) Arun T. John Peter et al.   JOURNAL OF CELL BIOLOGY

New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes

(2017) Kanji Okumoto et al.   JOURNAL OF CELL BIOLOGY

The Vps13p–Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion

(2017) Mithu De et al.   JOURNAL OF CELL BIOLOGY

Mutations inTMEM230are not a common cause of Parkinson's disease

(2017) Marialuisa Quadri et al.   MOVEMENT DISORDERS

Crystal structures of Mmm1 and Mdm12–Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites

(2017) Hanbin Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piecing Together the Patchwork of Contact Sites

(2017) Alberto T. Gatta et al.   TRENDS IN CELL BIOLOGY

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

(2017) Daniela Bakula et al.   Nature Communications

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain

(2017) Jan J. Vonk et al.   PLoS One

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phenotypic abnormalities in a chorea-acanthocytosis mouse model are modulated by strain background

(2016) Hitoshi Sakimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome

(2016) Sarah E. Murphy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites

(2016) Jae-Sook Park et al.   MOLECULAR BIOLOGY OF THE CELL

Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

(2016) Antonella Chiapparino et al.   PROGRESS IN LIPID RESEARCH

TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy inDictyosteliumand human HeLa cells

(2015) Sandra Muñoz-Braceras et al.   Autophagy

ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

(2015) Alexander B. Lang et al.   JOURNAL OF CELL BIOLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Cohen Syndrome-associated Protein COH1 Physically and Functionally Interacts with the Small GTPase RAB6 at the Golgi Complex and Directs Neurite Outgrowth

(2014) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis

(2014) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer

(2014) Curtis M. Schauder et al.   NATURE

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease

(2014) T. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

Insights into the mechanisms of sterol transport between organelles

(2013) Bruno Mesmin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SPO71 Encodes a Developmental Stage-Specific Partner for Vps13 in Saccharomyces cerevisiae

(2013) Jae-Sook Park et al.   EUKARYOTIC CELL

Cohen syndrome is associated with major glycosylation defects

(2013) Laurence Duplomb et al.   HUMAN MOLECULAR GENETICS

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

(2012) Anoop Kumar G. Velikkakath et al.   MOLECULAR BIOLOGY OF THE CELL

Synaptic Vesicle Endocytosis

(2012) Y. Saheki et al.   Cold Spring Harbor Perspectives in Biology

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity

(2011) L. De Franceschi et al.   BLOOD

Lipid transfer and signaling at organelle contact sites: the tip of the iceberg

(2011) Alexandre Toulmay et al.   CURRENT OPINION IN CELL BIOLOGY

Vacuolar Protein Sorting Protein 13A, TtVPS13A, Localizes to the Tetrahymena thermophila Phagosome Membrane and Is Required for Efficient Phagocytosis

(2011) Haresha S. Samaranayake et al.   EUKARYOTIC CELL

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

(2011) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections

(2011) B. Kornmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria

(2010) Klaus O. Kopec et al.   BIOINFORMATICS

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

(2008) Keisuke Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA