Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson’s Disease

Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration

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Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

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α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

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Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer

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ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2

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Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery

(2019) Rong Yu et al.   EMBO JOURNAL

Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra

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Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

(2019) Balvindar Singh et al.   ACTA NEUROPATHOLOGICA

Current Progress of Mitochondrial Quality Control Pathways Underlying the Pathogenesis of Parkinson’s Disease

(2019) Xue Jiang et al.   Oxidative Medicine and Cellular Longevity

Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer

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The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease

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Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616

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Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease

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Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein

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α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

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Structural basis of mitochondrial receptor binding and constriction by DRP1

(2018) Raghav Kalia et al.   NATURE

Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics

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The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases

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Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence

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Mitochondrial fusion, fission, and mitochondrial toxicity

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αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

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The MPTP Story

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Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Enteric neurons from Parkinson’s disease patients display ex vivo aberrations in mitochondrial structure

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In vitro exposure to very low-level laser modifies expression level of extracellular matrix protein RNAs and mitochondria dynamics in mouse embryonic fibroblasts

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MDS clinical diagnostic criteria for Parkinson's disease

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Mitotic redistribution of the mitochondrial network by Miro and Cenp-F

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Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation

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Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

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Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties

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Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis

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Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

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Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

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Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

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Fiji: an open-source platform for biological-image analysis

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Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1

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Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

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Synaptic Energy Use and Supply

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GSK3beta-Mediated Drp1 Phosphorylation Induced Elongated Mitochondrial Morphology against Oxidative Stress

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Mitochondrial dynamics in neurodegeneration

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DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson’s disease

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Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

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Crystal structure of nucleotide-free dynamin

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Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons

(2009) Takuma Uo et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

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Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY