VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

Diagnostic exome sequencing in early-onset Parkinson's disease confirms VPS13C as a rare cause of autosomal-recessive Parkinson's disease

(2018) B. Schormair et al.   CLINICAL GENETICS

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

(2018) Allyson L. Anding et al.   CURRENT BIOLOGY

Mitochondria, lysosomes and dysfunction: their meaning in neurodegeneration

(2018) Matteo Audano et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria

(2018) FoSheng Hsu et al.   eLife

Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes

(2018) Vanesa D. Ramseyer et al.   Molecular Metabolism

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling

(2018) Hannes Glaß et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endoplasmic reticulum–mitochondria junction is required for iron homeostasis

(2017) Yong Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Vps13p–Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion

(2017) Mithu De et al.   JOURNAL OF CELL BIOLOGY

Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease

(2017) Weronika Rzepnikowska et al.   TRAFFIC

Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders

(2017) Nicoletta Plotegher et al.   TRENDS IN MOLECULAR MEDICINE

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain

(2017) Jan J. Vonk et al.   PLoS One

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases

(2016) Marco Sardiello   Annals of the New York Academy of Sciences

Erythroid cell mitochondria receive endosomal iron by a “kiss-and-run” mechanism

(2016) Amel Hamdi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis

(2016) F. Lupo et al.   BLOOD

Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells

(2016) Willi Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts

(2016) Christiane Ott et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of communication between mitochondria and lysosomes

(2016) Nuno Raimundo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Endosome–mitochondria interactions are modulated by iron release from transferrin

(2016) Anupam Das et al.   JOURNAL OF CELL BIOLOGY

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization

(2016) Nancy Stanslowsky et al.   JOURNAL OF NEUROSCIENCE

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites

(2016) Jae-Sook Park et al.   MOLECULAR BIOLOGY OF THE CELL

Whole-exome and transcriptome sequencing of refractory diffuse large B-cell lymphoma

(2016) Ha Young Park et al.   Oncotarget

Identification of differentially expressed genes in the development of osteosarcoma using RNA-seq

(2016) Yihao Yang et al.   Oncotarget

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density

(2016) Kellie S. Gross et al.   PLoS One

TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy inDictyosteliumand human HeLa cells

(2015) Sandra Muñoz-Braceras et al.   Autophagy

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Chorein Sensitive Arrangement of Cytoskeletal Architecture

(2015) Sabina Honisch et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Function of Autophagy in Neurodegenerative Diseases

(2015) Yoshimitsu Kiriyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

(2015) Alexander B. Lang et al.   JOURNAL OF CELL BIOLOGY

Chorein Sensitive Dopamine Release from Pheochromocytoma (PC12) Cells

(2015) Sabina Honisch et al.   NEUROSIGNALS

Dissecting the function of Atg1 complex inDictyosteliumautophagy reveals a connection with the pentose phosphate pathway enzyme transketolase

(2015) Ana Mesquita et al.   Open Biology

Biodiversity on the Rocks: Macrofauna Inhabiting Authigenic Carbonate at Costa Rica Methane Seeps

(2015) Lisa A. Levin et al.   PLoS One

A Dynamic Interface between Vacuoles and Mitochondria in Yeast

(2014) Yael Elbaz-Alon et al.   DEVELOPMENTAL CELL

Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria

(2014) Carina Hönscher et al.   DEVELOPMENTAL CELL

Toward a Comprehensive Map of the Effectors of Rab GTPases

(2014) Alison K. Gillingham et al.   DEVELOPMENTAL CELL

Cohen Syndrome-associated Protein COH1 Physically and Functionally Interacts with the Small GTPase RAB6 at the Golgi Complex and Directs Neurite Outgrowth

(2014) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A universal cloning method based on yeast homologous recombination that is simple, efficient, and versatile

(2014) Tammy M. Joska et al.   JOURNAL OF MICROBIOLOGICAL METHODS

De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability

(2014) S E McCarthy et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

Comparative Proteomics Analysis of Gastric Cancer Stem Cells

(2014) Tamami Morisaki et al.   PLoS One

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Chorein Sensitivity of Actin Polymerization, Cell Shape and Mechanical Stiffness of Vascular Endothelial Cells

(2013) Ioana Alesutan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chorein sensitivity of cytoskeletal organization and degranulation of platelets

(2013) Eva-Maria Schmidt et al.   FASEB JOURNAL

Cohen syndrome is associated with major glycosylation defects

(2013) Laurence Duplomb et al.   HUMAN MOLECULAR GENETICS

Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis

(2012) Michael Föller et al.   FASEB JOURNAL

VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae

(2012) Jae-Sook Park et al.   JOURNAL OF CELL SCIENCE

A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort

(2012) Shashwath A. Meda et al.   NEUROIMAGE

Novel pathogenic mutations and copy number variations in the VPS13A Gene in patients with chorea-acanthocytosis

(2011) Akiyuki Tomiyasu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity

(2011) L. De Franceschi et al.   BLOOD

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

(2011) R. J. Strawbridge et al.   DIABETES

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

(2011) N. Grarup et al.   DIABETOLOGIA

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Vacuolar Protein Sorting Protein 13A, TtVPS13A, Localizes to the Tetrahymena thermophila Phagosome Membrane and Is Required for Efficient Phagocytosis

(2011) Haresha S. Samaranayake et al.   EUKARYOTIC CELL

Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability

(2011) Chang Hyeok An et al.   HUMAN PATHOLOGY

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

(2011) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children

(2011) Jan Windholz et al.   PLoS One

Autophagy in Stem Cell Maintenance and Differentiation

(2011) Alexandre Teixeira Vessoni et al.   STEM CELLS AND DEVELOPMENT

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas

(2011) Toru Furukawa et al.   Scientific Reports

Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila

(2010) Sze Man Tung et al.   CELLULAR MICROBIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

(2009) Brett A. McCray et al.   HUMAN MOLECULAR GENETICS

A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum

(2008) Douwe M. Veltman et al.   PLASMID