Membrane Trafficking Pathways in Alzheimer's Disease

Amyloid-β Decreases Cell-Surface AMPA Receptors by Increasing Intracellular Calcium and Phosphorylation of GluR2

(2017) Shi-Jie Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

AICD Nuclear Signaling and Its Possible Contribution to Alzheimers Disease

(2012) Uwe Konietzko   Current Alzheimer Research

Retromers in Alzheimer’s Disease

(2012) Barbara M. Siegenthaler et al.   Neurodegenerative Diseases

Inhibition of AMPA receptor trafficking at hippocampal synapses by β-amyloid oligomers: the mitochondrial contribution

(2012) Yanfang Rui et al.   Molecular Brain

Presenilins mediate efficient proteolysis via the autophagosome-lysosome system

(2011) Kara M. Neely et al.   Autophagy

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

(2011) Jing Wu et al.   CELL

The Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM

(2011) Sharon E. Miller et al.   CELL

The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9

(2011) Maria Dolores Gutiérrez-López et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

(2011) Xiaoyu Li et al.   EMBO JOURNAL

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation

(2011) Lujia Zhou et al.   EMBO Molecular Medicine

Inhibition of β-Secretasein Vivovia Antibody Binding to Unique Loops (D and F) of BACE1

(2011) Lujia Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large Quantities of Aβ Peptide Are Constitutively Released during Amyloid Precursor Protein Metabolismin Vivoandin Vitro

(2011) Abhay Moghekar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Cleavage at β′-Site Contributes to Apparent Increase in β-Amyloid Peptide (Aβ) Secretion by β-Secretase (BACE1)-Glycosylphosphatidylinositol (GPI) Processing of Amyloid Precursor Protein

(2011) Kulandaivelu S. Vetrivel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Intraneuronal APP, Not Free A  Peptides in 3xTg-AD Mice: Implications for Tau versus A -Mediated Alzheimer Neurodegeneration

(2011) M. J. Winton et al.   JOURNAL OF NEUROSCIENCE

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Retromer disruption promotes amyloidogenic APP processing

(2011) Christopher P. Sullivan et al.   NEUROBIOLOGY OF DISEASE

SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses

(2011) S. J. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Recent Advances in Retromer Biology

(2011) Ian J. McGough et al.   TRAFFIC

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease Progression

(2010) Stephen D. Ginsberg et al.   BIOLOGICAL PSYCHIATRY

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Investigation of 15 of the top candidate genes for late-onset Alzheimer’s disease

(2010) Olivia Belbin et al.   HUMAN GENETICS

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting β-Secretase Activity in Alzheimer's Disease Cell Models with Single-Chain Antibodies Specifically Targeting APP

(2010) Shanta Boddapati et al.   JOURNAL OF MOLECULAR BIOLOGY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease  - and  -Secretase via Distinct Mechanisms

(2010) S. Mitterreiter et al.   JOURNAL OF NEUROSCIENCE

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

(2010) Sandra I Vieira et al.   Molecular Neurodegeneration

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects

(2010) Kristel Sleegers et al.   TRENDS IN GENETICS

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

(2009) Daosong Xu et al.   FASEB JOURNAL

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

(2009) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity

(2009) Daniel R. Dries et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

(2009) Z. V. Goodger et al.   JOURNAL OF CELL SCIENCE

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

(2009) María Yáñez-Mó et al.   TRENDS IN CELL BIOLOGY

Retromer

(2008) Juan S Bonifacino et al.   CURRENT OPINION IN CELL BIOLOGY

Glu332in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity

(2008) Lucía Chávez-Gutiérrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

(2008) Haipeng Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing

(2008) Takashi Sakurai et al.   JOURNAL OF CELL BIOLOGY

Building γ-secretase – the bits and pieces

(2008) Dragana Spasic et al.   JOURNAL OF CELL SCIENCE

Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons

(2008) A. Schneider et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories

(2008) Uwe Konietzko et al.   NEUROBIOLOGY OF AGING

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Trafficking, a key player in regulated intramembrane proteolysis

(2008) Ragna Sannerud et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY