DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

(2019) Zhen-Hua Zhao et al.   Frontiers in Aging Neuroscience

Familial early onset Parkinson's disease caused by a homozygous frameshift variant in PARK7: Clinical features and literature update

(2019) Sarah EM Stephenson et al.   PARKINSONISM & RELATED DISORDERS

Chemical Probe To Monitor the Parkinsonism-Associated Protein DJ-1 in Live Cells

(2018) Jonas Drechsel et al.   ACS Chemical Biology

15 N CEST data and traditional model-free analysis capture fast internal dynamics of DJ-1

(2018) Jonathan Catazaro et al.   ANALYTICAL BIOCHEMISTRY

Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin , PINK1 , DJ1: MDSGene Systematic Review

(2018) Meike Kasten et al.   MOVEMENT DISORDERS

Diagnosis of Parkinson’s disease and the level of oxidized DJ-1 protein

(2018) Yuko Yamagishi et al.   NEUROSCIENCE RESEARCH

DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury

(2018) Lior Molcho et al.   PLoS One

Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease

(2018) Jihoon Jang et al.   Parkinsons Disease

Evaluation of cerebrospinal fluid proteins as potential biomarkers for early stage Parkinson’s disease diagnosis

(2018) Marcia Cristina T. dos Santos et al.   PLoS One

Discovery, validation and optimization of cerebrospinal fluid biomarkers for use in Parkinson’s disease

(2017) Lucia Farotti et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation

(2017) Seongmi Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

A Clinical and Molecular Genetic Study of 50 Families with Autosomal Recessive Parkinsonism Revealed Known and Novel Gene Mutations

(2017) Shaghayegh Taghavi et al.   MOLECULAR NEUROBIOLOGY

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease

(2016) Min Shi et al.   Alzheimers & Dementia

DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology

(2016) Ricardo Taipa et al.   BRAIN

DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7

(2016) M. Di Nottia et al.   CLINICAL GENETICS

Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson’s patients and genotype-phenotype correlations

(2016) Sevda Erer et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2016) Yoshihisa Kitamura et al.   JOURNAL OF ALZHEIMERS DISEASE

A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family

(2016) Hasmet A. Hanagasi et al.   PARKINSONISM & RELATED DISORDERS

Early Onset Parkinson's disease due to DJ1 mutations: An Indian study

(2016) Masoom M. Abbas et al.   PARKINSONISM & RELATED DISORDERS

Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy

(2016) Micaela Johanna Glat et al.   PLoS One

DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease

(2015) Kazuko Takahashi-Niki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2

(2015) Nirit Lev et al.   PLoS One

Oxidized DJ-1 as a possible biomarker of Parkinson’s disease

(2014) Yoshiro Saito   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The Parkinson's Disease-Related Protein DJ-1 Protects Dopaminergic Neurons in vivo and Cultured Cells from Alpha-Synuclein and 6-Hydroxydopamine Toxicity

(2014) Sara Batelli et al.   Neurodegenerative Diseases

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease

(2014) L Zondler et al.   Cell Death & Disease

DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease

(2013) Muhammad U. Sajjad et al.   HUMAN MOLECULAR GENETICS

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

Tat-DJ-1 Protects Neurons from Ischemic Damage in the Ventral Horn of Rabbit Spinal Cord Via Increasing Antioxidant Levels

(2013) Woosuk Kim et al.   NEUROCHEMICAL RESEARCH

Detection of copy number changes in genes associated with Parkinson's disease in Iranian patients

(2013) Hossein Darvish et al.   NEUROSCIENCE LETTERS

Neuroprotective Function of DJ-1 in Parkinson’s Disease

(2013) Hiroyoshi Ariga et al.   Oxidative Medicine and Cellular Longevity

Conservation of Oxidative Protein Stabilization in an Insect Homologue of Parkinsonism-Associated Protein DJ-1

(2012) Jiusheng Lin et al.   BIOCHEMISTRY

DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats

(2012) Shuang-Yong Sun et al.   BRAIN RESEARCH BULLETIN

DJ-1 Protects Dopaminergic Neurons against Rotenone-Induced Apoptosis by Enhancing ERK-Dependent Mitophagy

(2012) H. Gao et al.   JOURNAL OF MOLECULAR BIOLOGY

The DJ-1 concentration in cerebrospinal fluid does not differentiate among parkinsonian syndromes

(2012) Lisette Salvesen et al.   PARKINSONISM & RELATED DISORDERS

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes

(2012) Deepak Jain et al.   Journal of Molecular Cell Biology

Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7

(2011) Masatoshi Inden et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

(2011) Yoshihisa Kitamura et al.   Molecular Neurodegeneration

DJ-1 can inhibit microtubule associated protein 1 B formed aggregates

(2011) Zhiquan Wang et al.   Molecular Neurodegeneration

The Role of Cysteine Oxidation in DJ-1 Function and Dysfunction

(2010) Mark A. Wilson   ANTIOXIDANTS & REDOX SIGNALING

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments

(2010) Chenere P. Ramsey et al.   JOURNAL OF NEUROSCIENCE RESEARCH

PRKN, DJ-1, and PINK1 screening identifies novel splice site mutation in PRKN and two novel DJ-1 mutations

(2010) Farzaneh Ghazavi et al.   MOVEMENT DISORDERS

Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease

(2010) Min Shi et al.   NEUROSCIENCE LETTERS

Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson’s Disease-Linked PARK7

(2009) Koichiro Yamane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

(2009) Jeff Blackinton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7

(2009) Takashi Yanagida et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Differential DJ-1 gene expression in Parkinson's disease

(2009) Ravindran Kumaran et al.   NEUROBIOLOGY OF DISEASE

Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients

(2009) Yoshiro Saito et al.   NEUROSCIENCE LETTERS

DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson’s disease model rats

(2008) Shin Miyazaki et al.   JOURNAL OF NEUROCHEMISTRY

Mutation analysis ofParkin,PINK1,DJ-1andATP13A2genes in Chinese patients with autosomal recessive early-onset Parkinsonism

(2008) Ji-Feng Guo et al.   MOVEMENT DISORDERS

Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease

(2008) Maria G. Macedo et al.   MOVEMENT DISORDERS

DJ-1 is Essential for Long-Term Depression at Hippocampal CA1 Synapses

(2008) Yue Wang et al.   NEUROMOLECULAR MEDICINE

DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age

(2008) Steven J. Mullett et al.   NEUROPATHOLOGY

Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism

(2008) Patrizia Tarantino et al.   PARKINSONISM & RELATED DISORDERS

DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70

(2008) Sara Batelli et al.   PLoS One

Structural effects of Parkinson's disease linked DJ-1 mutations

(2008) Gaetano Malgieri et al.   PROTEIN SCIENCE