Journal
GENES & DEVELOPMENT
Volume 35, Issue 7-8, Pages 449-469Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.346759.120
Keywords
cellular homeostasis; communication; contact sites; endolysosomal pathway; interorganelle communication; lipid metabolism; mitochondria; aging; neurodegeneration
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Funding
- National Institutes of Health [R35NS097227, R21AG061468]
- Fyssen Postdoctoral Fellowship
- National Ataxia Young Investigator Award
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Intercellular communication between organelles plays a crucial role in coordinating cellular functions, and its dysfunction may contribute to aging and neurodegenerative diseases. This disruption is closely linked to age-related pathologies, highlighting the importance of studying the coordination mechanisms of organelle communication and function.
Our cells are comprised of billions of proteins, lipids, and other small molecules packed into their respective subcellular organelles, with the daunting task of maintaining cellular homeostasis over a lifetime. However, it is becoming increasingly evident that organelles do not act as autonomous discrete units but rather as interconnected hubs that engage in extensive communication through membrane contacts. In the last few years, our understanding of how these contacts coordinate organelle function has redefined our view of the cell. This review aims to present novel findings on the cellular interorganelle communication network and how its dysfunction may contribute to aging and neurodegeneration. The consequences of disturbed interorganellar communication are intimately linked with age-related pathologies. Given that both aging and neurodegenerative diseases are characterized by the concomitant failure of multiple cellular pathways, coordination of organelle communication and function could represent an emerging regulatory mechanism critical for long-term cellular homeostasis. We anticipate that defining the relationships between interorganelle communication, aging, and neurodegeneration will open new avenues for therapeutics.
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